LAB-Secretome DB


LAB-Secretome DB A comparative analysis of the predicted secretomes of Lactic Acid Bacteria

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Summary of results

Ubiquitous LaCOGs

Niche specific LaCOGs

Species specific

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Protein with distant homolog in non-LAB species

GI:90962785
NCBI info	90962785	Gene:	-	Synonym:	LSL_1812
SCL:	@N-terminally anchored (No CS)	Length	426	COG	-
Species:	Lactobacillus_salivarius_UCC118	Location	95157..96437	Strand:	-
Product:	Hypothetical secreted protein
Sequence:	MKKWIKTHSKLLVLCSIGGLGGFLIILVAIFTVLFFSNNRCSDNAGTSDTDISSGFTGSWTTQGTEAYKNAKATFEFWVSKGMSGAQAAGIVGNIGGAED TGFVLDQKEIGGGSGGGLYQFTPYTKYLNDPKSDKSWSVVNQGEVVMSLEPQTVSSFFSKTKNSSPGDAATDWMNMYERPSEKVRAVTNSMRRSAAEKAY ELLGGANISAKDSLLGDVTETSDIGVTSDLQNDSKTCSVSSDSASDGTGEVPKGVRDKIYAANEIPDSLKPYLLPINVSDARGVSGKGWSHPGGQCVDYV VSEATVLWNNTQSWSLGNGVDQVNSAIKFGYAVKDDKPHKGDLVSCDGTDPSIGHTWMVGHVFADGSVLLQEQNYPGKSGDDMGAPLTWDVAVLPPYKDG AWANLPNYGATLNHPVFAKPAHGMKK

Protein Domain structure of 90962785 (Scale up the web page to see more details)

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Distant Homologs of 90962785 in the non-LAB species

Alignment	GI	Species	Product	Length	Eval	Identities	Positives
Show aligned area	71903970	Streptococcus pyogenes MGAS6180	hypothetical protein M28_Spy1308	452	3e-24	0.32	0.43
LVAIFTVLFFSNN-RCSDNAGTSDTDISSGFTGS---WTTQGTEAYKNAKATFEFWVSKGMSGAQAAGIVG---------NIGGAE-DTGFVLDQKEIGG +V I T++F S+ C S ++S + S WT +G+ A A F WVSKG+SGA AAGIVG IG AE G L I IVVIVTIIFSSSQGDCQVTPDLSTQFVTSSDSASQTDWTKKGSIANVTAGKVFHAWVSKGLSGASAAGIVGWVNSEGGFAMIGRAEGHYGNDLRTNSIAF G------------SGGGLYQFTPYTKY--LNDPKSDKSWSV-------VNQGEVVMSLEPQTVSSFFSKTKNSSPGDAATDWMNMYERPSEKVRAVTNSM G +GGG+YQFTPYTKY L DPK + + ++ + G+ S++ + F + + AT YER S A N GVKPIGLSYYTTEAGGGIYQFTPYTKYAPLGDPKWENADAMNEFVAKAILAGDWNASMDLTGGNHTFKQMAQMTDPKQATLVWQAYERGST---AHINPF RRSA-AEKAYELLGGANISAKDSLLGDVTETSDI-GVTSDLQNDSKTCSVS-SDSASDGTGEVPKGVRDKI-------YAANEIPDSLKPYLLPINVSDA ++ A A+KAYEL GG S + + ++ DI G + +SK +S +S S G K K+ + ++P LKPY L QKQADAQKAYELFGGVKYSYNEIVF---HKSFDIFGPLKPGEGESKEVVLSLCESGSYSKGAFGKDRTGKVNYTSYNAWRPEQLPADLKPYALDPRSVGL RGVSGKGW---SHPGGQCVDYVVSEATVLWNNTQS---WSLGNGVDQVNSAIKFGYAVKDDKPHKGDLVSCDGTDPSIGHTWMVGHVFADGSVLLQEQNY GW + GGQC D S LW+ S GNG V + ++ D P G + S GT S GHT +V HVF +G +L+ EQNY NYRQAVGWYAIASTGGQCTDLSASLMYALWSKNGSHPTQKAGNGNMVVANWVRTFGGSSDKSPTSGAVFSSAGTS-SAGHTGVVSHVFENGDILIVEQNY PGKSGDDMG-APLTWDVAVLPPYKDGAWANLPNYGATLNHP SGDD G +W+ Y+ A L N G T +P ASYSGDDGGFGKYSWN------YRYVTTAELKNEGYTFYNP
Show aligned area	94990892	Streptococcus pyogenes MGAS10270	hypothetical protein MGAS10270_Spy1383	452	3e-24	0.32	0.43
LVAIFTVLFFSNN-RCSDNAGTSDTDISSGFTGS---WTTQGTEAYKNAKATFEFWVSKGMSGAQAAGIVG---------NIGGAE-DTGFVLDQKEIGG +V I T++F S+ C S ++S + S WT +G+ A A F WVSKG+SGA AAGIVG IG AE G L I IVVIVTIIFSSSQGDCQVTPDLSTQFVTSSDSASQTDWTKKGSIANVTAGKVFHAWVSKGLSGASAAGIVGWVNSEGGFAMIGRAEGHYGNDLRTNSIAF G------------SGGGLYQFTPYTKY--LNDPKSDKSWSV-------VNQGEVVMSLEPQTVSSFFSKTKNSSPGDAATDWMNMYERPSEKVRAVTNSM G +GGG+YQFTPYTKY L DPK + + ++ + G+ S++ + F + + AT YER S A N GVKPIGLSYYTTEAGGGIYQFTPYTKYAPLGDPKWENADAMNEFVAKAILAGDWNASMDLTGGNHTFKQMAQMTDPKQATLVWQAYERGST---AHINPF RRSA-AEKAYELLGGANISAKDSLLGDVTETSDI-GVTSDLQNDSKTCSVS-SDSASDGTGEVPKGVRDKI-------YAANEIPDSLKPYLLPINVSDA ++ A A+KAYEL GG S + + ++ DI G + +SK +S +S S G K K+ + ++P LKPY L QKQADAQKAYELFGGVKYSYNEIVF---HKSFDIFGPLKPGEGESKEVVLSLCESGSYSKGAFGKDRTGKVNYTSYNAWRPEQLPADLKPYALDPRSVGL RGVSGKGW---SHPGGQCVDYVVSEATVLWNNTQS---WSLGNGVDQVNSAIKFGYAVKDDKPHKGDLVSCDGTDPSIGHTWMVGHVFADGSVLLQEQNY GW + GGQC D S LW+ S GNG V + ++ D P G + S GT S GHT +V HVF +G +L+ EQNY NYRQAVGWYAIASTGGQCTDLSASLMYALWSKNGSHPTQKAGNGNMVVANWVRTFGGSSDKSPTSGAVFSSAGTS-SAGHTGVVSHVFENGDILIVEQNY PGKSGDDMG-APLTWDVAVLPPYKDGAWANLPNYGATLNHP SGDD G +W+ Y+ A L N G T +P ASYSGDDGGFGKYSWN------YRYVTTAELKNEGYTFYNP
Show aligned area	125717042	Streptococcus sanguinis SK36	hypothetical protein SSA_0164	479	1e-19	0.37	0.51
EKAYELLGGANISAKDSLLGDVTETSDIGVTSDLQNDSKTCSVSSDS-----ASDGTGEVPKGVRDKIYAANEIPDSLKPYLL-PINVSDARGVSGKGWS EKA G + ++A S +D G S + K C+ S + A DG+G+VP+ + IY + +P SL PYLL P G SG W EKAISQYGSSPVAATSSGGDSSGSETDSGSPSSSRPKKKGCNDGSSTGTNGDAVDGSGKVPEDITAAIYTPSTLPASLNPYLLDPRAFGMEYGGSGANWE HP-----GGQCVDYVVSEATVLWNNTQSWSLGNGVDQVNS-AIKFGYAVKDDKPHKGDLVSC--DGTDPSIGHTWMVGHVFADGSVLLQEQNYPGKSGDD HP GQCV+ +S +LW + + +GNG+DQ ++ A FG + K P KG + SC D +P+ GHT +V HVF DGS+L EQN SG + HPDEFYLAGQCVNLTISFGNILWGH-KGVVIGNGIDQADAWARIFGNSTK-KAPKKGAIFSCLSDSGNPA-GHTGIVCHVFEDGSILTCEQN-SMVSGTN MGAPLTWDVAVLPP G P TW V+ P AGKPFTWHYCVIRP
Show aligned area	22538134	Streptococcus agalactiae 2603V/R	hypothetical protein SAG1998	457	2e-19	0.28	0.43
SDNAGTSDTDISSGFTGSWTTQGTEAYKNAKATFEFWVSKGMSGAQAAGIVGNIGGAEDTGFVLDQKEIG------------------------GGSGGG S+NA SD WT +GT A + A+ F WVSKG+SGA A+GIVG + + GF + + G +GGG SENASNSD----------WTKKGTVANQTAEKVFNAWVSKGLSGASASGIVGWVN--SEGGFAMIGRAEGHYGNDLKTNSIAFNVRPTGLSYYTTEAGGG LYQFTPYTKY--LNDPKSDKSWSV-------VNQGEVVMSLEPQTVSSFFSKTKNSSPGDAATDWMNMYERPSEKVRAVTNSMRRSA-AEKAYELLGGAN +YQ TP+TKY L DPK + + ++ + G+ +++ + F + + AT N YER + A N +++A +KAYE+ G+ IYQITPFTKYAPLGDPKWEDADAMNAFVMKSIKSGDWNKAMDLSGGNHSFEEMAQMTDPKQATLVWNAYERGNT---AYINKAQKTADGQKAYEIFNGSK I---SAKDSLLGDVTETSDIGVTSDLQNDSKTCSVSSDSASDGTGEVPKGVRDKI-------YAANEIPDSLKPYLLPINVSDARGVSGKGW---SHPGG + K S + SD+ +DS S+ +++ G K K+ + +++P LK Y + + GW + GG YKFDAEKFSKSFGGGSKTSSSGKSDIISDSTVLSLCDSASNAVQGLFGKDKSGKVKYTSYNAWKPDQLPSDLKKYAIDPKSVGLFYRTSSGWNAIASTGG QCVDYVVSEATVLW---NNTQSWSLGNGVDQVNSAIKFGYAVKDDKPHKGDLVSCDGTDPSIGHTWMVGHVFADGSVLLQEQNYPGKSGDDMG-APLTWD QC D S LW + +GNG V++ + ++ P G + S GT S GHT +V HVF +G +L+ EQNY SGD+ G P +W+ QCTDLSASLMYGLWLKGGMHPTQRMGNGNMVVSNWVSAFGGRSENTPSSGAVFSSSGTS-SAGHTGVVSHVFENGDMLIVEQNYSTYSGDNRGFGPYSWN
Show aligned area	25011028	Streptococcus agalactiae NEM316	hypothetical protein gbs0975	445	4e-15	0.35	0.48
KAYELLGGANISAKDSLLGDVTETS--DIGVTSDLQNDSKTCS-VSSDSASDGTGEVPKGVRDKIYAANEIPDSLKPYLLPINVSDARGVSGKGWSHPG- K YE L ISA T S D G++ ++SK CS SS A+DGTG VP Y + +P+SLK Y++ + GW +PG KTYEWLDKEAISAHGDKPYKATTASAGDAGLSDIFTSNSKDCSDSSSGGATDGTGTVPADAIAWGYRPDNLPESLKQYIIDPKSLGMAYANSSGWFNPGS ----GQCVDYVVSEATVLWNNTQSWSLGNGVDQVNS-AIKFGYAVKDDKPHKGDLVSCDGTDPSIGHTWMVGHVFADGSVLLQEQNYPGKSGDDMGAPLT GQCV+ +S LW ++ S S GNG DQ + A FG +VK P +G + S GHT +V HVF +GS+L+ EQN P D T DYLAGQCVNLTISLGNHLWGHSGSVS-GNGKDQAGAWANIFGNSVKT-TPKRGAIFSTQNGGGGYGHTGIVCHVFENGSILIVEQNTPLSGADYFKKSYT WDVAVLPPYKDGA W+ + P + A WNYRIWTPAQQKA
Show aligned area	25010789	Streptococcus agalactiae NEM316	hypothetical protein gbs0734	445	4e-15	0.35	0.48
KAYELLGGANISAKDSLLGDVTETS--DIGVTSDLQNDSKTCS-VSSDSASDGTGEVPKGVRDKIYAANEIPDSLKPYLLPINVSDARGVSGKGWSHPG- K YE L ISA T S D G++ ++SK CS SS A+DGTG VP Y + +P+SLK Y++ + GW +PG KTYEWLDKEAISAHGDKPYKATTASAGDAGLSDIFTSNSKDCSDSSSGGATDGTGTVPADAIAWGYRPDNLPESLKQYIIDPKSLGMAYANSSGWFNPGS ----GQCVDYVVSEATVLWNNTQSWSLGNGVDQVNS-AIKFGYAVKDDKPHKGDLVSCDGTDPSIGHTWMVGHVFADGSVLLQEQNYPGKSGDDMGAPLT GQCV+ +S LW ++ S S GNG DQ + A FG +VK P +G + S GHT +V HVF +GS+L+ EQN P D T DYLAGQCVNLTISLGNHLWGHSGSVS-GNGKDQAGAWANIFGNSVKT-TPKRGAIFSTQNGGGGYGHTGIVCHVFENGSILIVEQNTPLSGADYFKKSYT WDVAVLPPYKDGA W+ + P + A WNYRIWTPAQQKA
Show aligned area	25010477	Streptococcus agalactiae NEM316	hypothetical protein gbs0404	445	4e-15	0.35	0.48
KAYELLGGANISAKDSLLGDVTETS--DIGVTSDLQNDSKTCS-VSSDSASDGTGEVPKGVRDKIYAANEIPDSLKPYLLPINVSDARGVSGKGWSHPG- K YE L ISA T S D G++ ++SK CS SS A+DGTG VP Y + +P+SLK Y++ + GW +PG KTYEWLDKEAISAHGDKPYKATTASAGDAGLSDIFTSNSKDCSDSSSGGATDGTGTVPADAIAWGYRPDNLPESLKQYIIDPKSLGMAYANSSGWFNPGS ----GQCVDYVVSEATVLWNNTQSWSLGNGVDQVNS-AIKFGYAVKDDKPHKGDLVSCDGTDPSIGHTWMVGHVFADGSVLLQEQNYPGKSGDDMGAPLT GQCV+ +S LW ++ S S GNG DQ + A FG +VK P +G + S GHT +V HVF +GS+L+ EQN P D T DYLAGQCVNLTISLGNHLWGHSGSVS-GNGKDQAGAWANIFGNSVKT-TPKRGAIFSTQNGGGGYGHTGIVCHVFENGSILIVEQNTPLSGADYFKKSYT WDVAVLPPYKDGA W+ + P + A WNYRIWTPAQQKA

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