LAB-Secretome DB


LAB-Secretome DB A comparative analysis of the predicted secretomes of Lactic Acid Bacteria

Protein with distant homolog in non-LAB species

GI:29377946
NCBI info	29377946	Gene:	-	Synonym:	EF_B0054
SCL:	@N-terminally anchored (No CS)	Length	134	COG	COG0526OC
Species:	Enterococcus_faecalis_V583	Location	48454..48858	Strand:	+
Product:	hypothetical protein
Sequence:	MKKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNI TQTPTVIIIKEGKVYKRLEGVSSYELLEESLIKE

Protein Domain structure of 29377946 (Scale up the web page to see more details)

View this figure in PNG format

Distant Homologs of 29377946 in the non-LAB species

Alignment	GI	Species	Product	Length	Eval	Identities	Positives
Show aligned area	16079205	Bacillus subtilis subsp. subtilis str. 168	thiol-disulfide oxidoreductase	137	7e-09	0.33	0.51
MKKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNI MKK I +V + I + S E+ Y + + ++ K IY ++ C PC K +LN+VIK + L V ++IEEK + LD+ N+ MKKWIVLFLVLIAAAISIFVYVSTGSEKPFYNDINLTQYQKEVDSKKPKFIYVYETSCPPCQEIKPELNEVIKKEKLKVQALNIEEKENYNTEFLDKYNL TQTPTVIIIKEGKVYKRLEGVSSYELLEE +TPT++ K+GK RLEG S +E+ NKTPTILYYKDGKEKDRLEGYRSASQIEK
Show aligned area	152974461	Bacillus cereus subsp. cytotoxis NVH 391-98	thioredoxin domain-containing protein	136	5e-07	0.35	0.54
MKKMI--GGLVVGLFVLIFFWQLYSLNKEEIEY--KITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLD MKK++ GG+V+ LFV ++ + N ++ Y KIT E + I+ KD IYF++ C C + + KD N+ + +DIE KE + + D MKKLLIFGGIVIVLFVALWGVRFMEDNSKKDYYANKIT-LEELRKNITDKKDQTIYFYQTNCVHCQKVSPIVVPLAKDLNVDMKVIDIE---KEPDAVWD QLNITQTPTVIIIKEGKVYKRLEG + NI TPT+I KEGK R+ G EFNIKGTPTIIHYKEGKEVSRISG
Show aligned area	67077909	Bacillus cereus E33L	disulfide bond formation protein A	138	2e-06	0.28	0.50
KKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNIT K + LV+ + + F+ S + ++ EY D + + KI+ + IY +K C C K LN+VIK+ V+ +++E + L + NI KILFSSLVILISIGSLFFIFTSKDLDKPEYTNIDMKEYKGKINSKDNFYIYVYKTSCTACQSTKPFLNEVIKEDKKKVFAINMESEENMDIEFLKKNNIQ QTPTVIIIKEGKVYKRLEGVSSYELLEESL +TPT++ K G+ R+EG+ S L+ L KTPTLLKYKNGEEMNRVEGIQSKSELKSFL
Show aligned area	222094511	Bacillus cereus Q1	thioredoxin	139	4e-05	0.29	0.47
MKKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDS----------ESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKE MKKM L+ G +++ F ++++ + E + TD E + I K+ IYF++ C C + + KD N+ + +DIE N+ MKKM---LIFGGIIIVLFAAIFAVTQMEKKSASTDEKGYYSNKISLEDLNKNIEDKKEQTIYFYQTSCVHCQKVSPTVVPLAKDLNVDMKVIDIENLNEP SNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEE D+ NI TPT+I K+GK R+ G S E +E ----WDKYNIQGTPTIIHFKDGKEVSRISGEQSKEKFKE
Show aligned area	217958346	Bacillus cereus AH187	putative thioredoxin	139	4e-05	0.29	0.47
MKKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDS----------ESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKE MKKM L+ G +++ F ++++ + E + TD E + I K+ IYF++ C C + + KD N+ + +DIE N+ MKKM---LIFGGIIIVLFAAIFAVTQMEKKSASTDEKGYYSNKISLEDLNKNIEDKKEQTIYFYQTSCVHCQKVSPTVVPLAKDLNVDMKVIDIENLNEP SNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEE D+ NI TPT+I K+GK R+ G S E +E ----WDKYNIQGTPTIIHFKDGKEVSRISGEQSKEKFKE
Show aligned area	71903990	Streptococcus pyogenes MGAS6180	hypothetical protein M28_Spy1328	146	8e-05	0.27	0.53
KKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNIT K++ G L++ +L+ W S N+++ ++T + E ++Q +N+ F+KK C C V KK++ KD ++ Y VD E L+ + ++ KEIFGVLLLSPVILLIMWGYVSSNQDD--GRLTQKQYYETVVNQT--VNLVFYKKSCPYCKVAKKEIATQAKDSQVITYYVDTS--TGEGQKLVKKYHVK QTPTVIIIKEGKV PT++ I++G + YAPTIVSIRKGNI
Show aligned area	94990911	Streptococcus pyogenes MGAS10270	glutaredoxin-like protein	146	8e-05	0.27	0.53
KKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNIT K++ G L++ +L+ W S N+++ ++T + E ++Q +N+ F+KK C C V KK++ KD ++ Y VD E L+ + ++ KEIFGVLLLSPVILLIMWGYVSSNQDD--GRLTQKQYYETVVNQT--VNLVFYKKSCPYCKVAKKEIATQAKDSQVITYYVDTS--TGEGQKLVKKYHVK QTPTVIIIKEGKV PT++ I++G + YAPTIVSIRKGNI
Show aligned area	52144564	Bacillus cereus E33L	thioredoxin	139	1e-04	0.28	0.47
MKKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDS----------ESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKE MKKM L+ G +++ F ++++ + E + TD E + I K+ IYF++ C C + + KD N+ + +DIE N+ MKKM---LIFGGIIIVLFAAIFAVTQMEKKSASTDEKGYYSNKISLEDLNKNIEDKKEQTIYFYQTSCVHCQKVSPIVVPLAKDLNVDMKVIDIENLNEP SNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEE D+ NI TPT+I K+GK R+ G S + +E ----WDKYNIQGTPTIIHFKDGKEVSRISGEQSKDKFKE
Show aligned area	123968858	Prochlorococcus marinus str. AS9601	putative thioredoxin reductase	458	2e-04	0.32	0.49
LNKEEIEYKITDSESIENKIS---------QNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNITQTPTVIIIKEGKV N+EE+ DS S K S K + + F C PC+V K L +VIK+ + V GV+I + +K+ N + Q I TPTV + KE + FNEEEVNEDTFDSNSEWQKGSYALRKLYHESKKPILVIFSSPSCGPCHVLKPQLKRVIKELDGAVLGVEI-DIDKDQN-IAKQAGINGTPTVQLFKEKLL YKRLEGVSSYELLEESL K+ +GV +E++ KKQWQGVKQRSEFKEAI
Show aligned area	218901946	Bacillus cereus AH820	putative thioredoxin	139	2e-04	0.28	0.47
MKKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDS----------ESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKE MKKM L+ G +++ F ++++ + E + TD E + I K+ IYF++ C C + + KD N+ + +DIE N+ MKKM---LIFGGIIIVLFAAIFAVTQMEKKNASTDEKGYYSNKISLEDLNKNIEDKKEQTIYFYQTSCVHCQKVSPIVVPLAKDLNVDMKVIDIENLNEP SNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEE D+ NI TPT+I K+GK R+ G S + +E ----WDKYNIQGTPTIIHFKDGKEVSRISGEQSKDKFKE
Show aligned area	49480298	Bacillus thuringiensis serovar konkukian str. 97-27	thioredoxin	139	2e-04	0.28	0.47
MKKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDS----------ESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKE MKKM L+ G +++ F ++++ + E + TD E + I K+ IYF++ C C + + KD N+ + +DIE N+ MKKM---LIFGGIIIVLFAAIFAVTQMEKKNASTDEKGYYSNKISLEDLNKNIEDKKEQTIYFYQTSCVHCQKVSPIVVPLAKDLNVDMKVIDIENLNEP SNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEE D+ NI TPT+I K+GK R+ G S + +E ----WDKYNIQGTPTIIHFKDGKEVSRISGEQSKDKFKE
Show aligned area	118476430	Bacillus thuringiensis str. Al Hakam	thioredoxin	139	2e-04	0.28	0.47
MKKMIGGLVVGLFVLIFFWQLYSLNKEEIEYKITDS----------ESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKE MKKM L+ G +++ F ++++ + E + TD E + I K+ IYF++ C C + + KD N+ + +DIE N+ MKKM---LIFGGIIIVLFAAIFAVTQMEKKNASTDEKGYYSNKISLEDLNKNIEDKKEQTIYFYQTSCVHCQKVSPIVVPLAKDLNVDMKVIDIENLNEP SNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEE D+ NI TPT+I K+GK R+ G S + +E ----WDKYNIQGTPTIIHFKDGKEVSRISGEQSKDKFKE
Show aligned area	44004353	Bacillus cereus ATCC 10987	hypothetical protein BCE_A0014	160	2e-04	0.26	0.48
KITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSS K E ++ KI +K+ Y+++ C C D+N++ K + +Y +DI +S + +I TP ++ G+ +RLEG S KDISKEELKQKIQSHKEFIAYYYQPTCHYCKKAAPDINRMSKKHDRTIYRIDISTPENQS--AFQEFDIPGTPVIVAYNRGEEVERLEGAVS
Show aligned area	124485138	Methanocorpusculum labreanum Z	hypothetical protein Mlab_0311	102	2e-04	0.39	0.57
FFKKGCQPCNVQKKDLNKVIKDKNLLV--YGVDIEEKNKESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEESLIK FF C PC +Q ++ + K LV VD++E +N + +I+ PT+II K+GKV +RLEGV+ L ESL+K FFATWCGPCRIQSPIVHDLAKKMEGLVDVQMVDVDEHGDLAN----KYSISVVPTLIIEKDGKVIQRLEGVTDAATL-ESLLK
Show aligned area	126696678	Prochlorococcus marinus str. MIT 9301	putative thioredoxin reductase	458	2e-04	0.31	0.49
LNKEEIEYKITDSESIENKIS---------QNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIE-EKNKESNLLLDQLNITQTPTVIIIKEGK N+EE+ DS S K S K + + F C PC+V K L +VIK+ + V GV+I+ +K+++ + Q I TPTV + KE FNEEEVNEDTFDSNSEWQKGSYALRKLYHESKKPILVIFSSPSCGPCHVLKPQLKRVIKELDGAVLGVEIDIDKDQD---IAKQAGINGTPTVQLFKEKL VYKRLEGVSSYELLEESL + K+ +GV +E++ LKKQWQGVKQRSEFKEAI
Show aligned area	157413690	Prochlorococcus marinus str. MIT 9215	putative thioredoxin reductase	458	2e-04	0.31	0.48
LNKEEIEYKITDSESIENKIS---------QNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIE-EKNKESNLLLDQLNITQTPTVIIIKEGK N EE+ DS S K S K L + F C PC+V K L +VIK+ + V GV+I+ +K+++ + Q I TPTV + KE FNDEEVNEDTFDSNSEWQKGSYALRKLYHESKKPLLVIFSSPSCGPCHVLKPQLKRVIKELDGAVLGVEIDIDKDQD---IAKQAGINGTPTVQLFKEKL VYKRLEGVSSYELLEESL + K+ +GV +E++ LKKQWQGVKQRSEFKEAI
Show aligned area	219851663	Candidatus Methanosphaerula palustris E1-9c	Thioredoxin domain protein	91	3e-04	0.36	0.61
NKDLNIYFFKKGCQPCNVQKKDLNKVIKDK---NLLVYGVDIEEKNKESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEESL +K + I F+ + C PC +Q +++ +K+K + V +D+++ KE+ + I+ PT+II +GKV KRLEGV+S E LE+ L SKPVLIDFYAEWCGPCKMQSPLIDR-LKEKMGDAIEVRKMDVDQHMKEAG----EYQISVVPTLIIEMDGKVVKRLEGVTSAEDLEQML
Show aligned area	78779630	Prochlorococcus marinus str. MIT 9312	thioredoxin reductase	458	3e-04	0.30	0.49
LNKEEIEYKITDSESIENKIS---------QNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIE-EKNKESNLLLDQLNITQTPTVIIIKEGK N++E+ DS S K S K L + F C PC+V K L ++IK+ N V GV+I+ +K+++ + Q I TPTV + K+ FNEDEVNEDTFDSNSEWQKGSYALRKLYHESKKPLLVIFSSPSCGPCHVLKPQLKRIIKELNGAVLGVEIDIDKDQD---IAKQAGINGTPTVQLFKDKL VYKRLEGVSSYELLEESL + K+ +GV +E++ LKKQWQGVKQRSEFKEAI
Show aligned area	47566438	Bacillus anthracis str. 'Ames Ancestor'	hypothetical protein GBAA_pXO1_0118	160	4e-04	0.26	0.48
KITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSS K E ++ KI +++ Y+++ C C D+N++ K + +Y +DI +S + +I TP V+ G+ +RLEG S KDISKEELKQKIQSHEEFIAYYYQPTCHYCKKAAPDINRMSKKHDRTIYRIDISTSENQS--AFQEFDIPGTPVVVAYNRGEEVERLEGAVS
Show aligned area	221642289	Bacillus cereus Q1	hypothetical protein BCQ_PI199	160	4e-04	0.26	0.47
KITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSS K E ++ KI +++ Y+++ C C D+N + K + +Y +DI +S + +I TP V+ G+ +RLEG S KDISKEELKQKIQSHEEFIAYYYQPTCHYCKKAAPDINSMSKKHDRTIYRIDISTPENQS--AFQEFDIPGTPVVVAYNRGEEIERLEGAVS
Show aligned area	218848406	Bacillus cereus AH820	hypothetical protein BCAH820_B0179	160	4e-04	0.26	0.47
KITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSS K E ++ KI +++ Y+++ C C D+N + K + +Y +DI +S + +I TP V+ G+ +RLEG S KDISKEELKQKIQSHEEFIAYYYQPTCHYCKKAAPDINSMSKKHDRTIYRIDISTPENQS--AFQEFDIPGTPVVVAYNRGEEIERLEGAVS
Show aligned area	42779899	Bacillus cereus ATCC 10987	thioredoxin, putative	139	4e-04	0.29	0.48
MKKMI--GGLVVGLFVLIFFW-----QLYSLNKEEIEYKITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNL MKK++ GG+++ LF +F + S N+++ E + I K+ IYF++ C C + + KD N+ + +DIE N+ MKKILIFGGIIIVLFAAMFAVAQMEKKNASTNEKDYYSNKISLEDLNKNIEDKKEQTIYFYQTSCVHCQKVSPIVVPLAKDLNVDMKVIDIENLNEP--- LLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEE D+ NI TPT+I K+GK R+ G S E +E -WDKYNIQGTPTIIHFKDGKEVSRISGEQSKEKFKE
Show aligned area	217956821	Bacillus cereus AH187	hypothetical protein BCAH187_C0180	160	5e-04	0.26	0.47
KITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSS K E ++ KI +++ Y+++ C C D+N + K + +Y +DI +S + +I TP V+ G+ +RLEG S KDISKEELKQKIQSHEEFIAYYYQPTCHYCKKAAPDINSMSKKHDRTIYRIDISTPENQS--AFQEFDIPGTPVVVAYNRGEEIERLEGAVS
Show aligned area	123966548	Prochlorococcus marinus str. MIT 9515	putative thioredoxin reductase	458	6e-04	0.29	0.49
SLNKEEIEYKITDSESIENKIS---------QNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIE-EKNKESNLLLDQLNITQTPTVIIIKEG S N+EE + D S K S NK + + F C PC+V K L +VI + + V G++I+ +K++E + Q I TPT+ + KE SFNEEETDENTFDLNSKWQKGSYALRKLYHESNKPILVIFSSPSCGPCHVLKPQLKRVINEFDGAVQGIEIDIDKDQE---IAKQAGINGTPTIQLFKEK KVYKRLEGVSSYELLEESL + K+ +GV +E++ LLKKQWQGVKQRSEFKEAI
Show aligned area	218847949	Bacillus cereus G9842	hypothetical protein BCG9842_0087	141	6e-04	0.34	0.47
IEYKITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNKESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYE I K D + EN D +YFFK C+ C D+ K KD N+ + VD+ +K E L D I TPT+I G+ +R++G YE ISIKELDEKKYEN------DTYVYFFKPDCKFCKQANDDIYKAAKDTNVNLNRVDLSKKENER--LWDDHLIGGTPTIIHFNRGEEVERIQGAMPYE
Show aligned area	159903765	Prochlorococcus marinus str. MIT 9211	putative thioredoxin reductase	463	6e-04	0.32	0.51
NKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIE-EKNKESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEESLI NK L I + K C PC+V K L +V+ + GV+I+ E + E + Q + TPTV + K K++ +GV + +E +I NKPLLIVYTSKSCGPCHVLKPQLKRVLNELKGQALGVEIDIELDTE---IAKQAGVNGTPTVQLFKSKKLHNEWQGVKQRSVFKEEII
Show aligned area	15828655	Mycoplasma pulmonis UAB CTIP	thioredoxin	125	7e-04	0.28	0.49
YSLNKEEIEYKITDSESIENKISQNKDLNIYFFKKGCQPCNVQKKDLNKVI---KDK-NLLVYGVDIEEKNKESNLLLDQLNITQTPTVIIIKEGKVYKR Y L K E+E K+ + + + F++ GC PC++ K +L K++ KDK L + ++ + K+ E + ++ TPT I K+GK+ YDLKKSEVEPKLKEGVKV-----------LSFYQIGCPPCDMIKPELVKLVEKNKDKMELFLVRINRDGKHDEERRWAAESGVSATPTTFIYKDGKIVNT LEGVSSYELLEESLIK + G +LEE + K IVGYKPLSVLEEEMSK
Show aligned area	222094971	Bacillus cereus Q1	thioredoxin	161	7e-04	0.31	0.46
MKKMI--GGLVVGLFVLIFFWQLYSLNKEEIEYKITDSESIENKIS---------QNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNK MKKMI +++ + IFF Q + N+E KI D +N IS N+ IYF+K+GC C + + KDKN+ + +++ E MKKMILFSLVIISILSGIFFVQKGNKNQELEVSKIQDGNYYQNSISIKQLKADLINNEKHVIYFYKEGCLYCEQVSPIIVPMAKDKNIPMKVINLGEYPI ESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSS E D I PT++ + GK R+EG S EE---WDNFRIEAVPTIVEYRNGKEKNRIEGAHS
Show aligned area	217958825	Bacillus cereus AH187	thioredoxin	161	7e-04	0.31	0.46
MKKMI--GGLVVGLFVLIFFWQLYSLNKEEIEYKITDSESIENKIS---------QNKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIEEKNK MKKMI +++ + IFF Q + N+E KI D +N IS N+ IYF+K+GC C + + KDKN+ + +++ E MKKMILFSLVIISILSGIFFVQKGNKNQELEVSKIQDGNYYQNSISIKQLKADLINNEKHVIYFYKEGCLYCEQVSPIIVPMAKDKNIPMKVINLGEYPI ESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSS E D I PT++ + GK R+EG S EE---WDNFRIEAVPTIVEYRNGKEKNRIEGAHS
Show aligned area	33861706	Prochlorococcus marinus subsp. pastoris str. CCMP1986	putative thioredoxin reductase	458	9e-04	0.31	0.56
NKDLNIYFFKKGCQPCNVQKKDLNKVIKDKNLLVYGVDIE-EKNKESNLLLDQLNITQTPTVIIIKEGKVYKRLEGVSSYELLEESL NK + + F C PC+V K L +VIK+ + V G++I+ +K++E + Q I TPT+ + K+ + K+ +GV +E++ NKPILVIFSSPSCGPCHVLKPQLKRVIKEFDGAVQGIEIDIDKDQE---IAKQAGINGTPTIQLFKDKLLKKQWQGVKQRSEFKEAI