LAB-Secretome DB


LAB-Secretome DB A comparative analysis of the predicted secretomes of Lactic Acid Bacteria

Protein with distant homolog in non-LAB species

GI:29376362
NCBI info	29376362	Gene:	-	Synonym:	EF1818
SCL:	@Secretory(released) (with CS)	Length	510	COG	COG3227E
Species:	Enterococcus_faecalis_V583	Location	1762961..1764493	Strand:	-
Product:	coccolysin
Sequence:	MMKGNKILYILGTGIFVGSSCLFSSLFVAAEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGA VTSVTGNPVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLK NSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAF WDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQ YDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKEDIQVN QPSESVLVNE

Protein Domain structure of 29376362 (Scale up the web page to see more details)

View this figure in PNG format

Distant Homologs of 29376362 in the non-LAB species

Alignment	GI	Species	Product	Length	Eval	Identities	Positives
Show aligned area	222151918	Macrococcus caseolyticus JCSC5402	zinc metalloproteinase aureolysin homolog	510	5e-44	0.32	0.49
VYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDR-------NGAVTSVTGNPVDQVVKIQSVDAIGEEGV + S+ EV T+L L + +QY V + ++D G H L + +G + +H + NGA+ + T P + V I S AI E IQSKKEVKTILKDLPGYKNLKKNYKQYEVTNVEKDNLGYVHYTLHPKAKGKFATDQEIKVHTNDKGEVILVNGAIEAKTIAPTNNV-NIDSKTAISEAFK KKIIASDNPET-KDLVFLAIDKRVN-NEGQLFYKVRVTS-SPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGT I D + D V + + ++ ++ +L Y + +T+ SP + K++A +G ++EK +L + V + T + ++ + + G AL SLSINEDKADNLGDKVIKSSNVVIDGDKNKLVYDIEITTVSPKVGHWKV--KIDADNGQVLEKLNLIQEVATVGTGRGVLGDTKSININSISKGYALQDL DNTGVYHAV----VDGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPT N G A +G N + NQ A VDA + +Y++ F R S D+ G PI S+V + D +NA W G M YG+ T TNKGQISAYSLNQYNGSANLITDYDKVFDSNNQRAGVDANYYAAQTYKFYKNRFNRESYDNNGSPINSIVHVNNYGGQDNTNNAAWIGDKMIYGDGDGRT GKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYD + + DVV HE+THGVT+ TA LEY GQSGALNES+SD+ GY + S+ +G D + + +R+L P GQPE M+QY + D FTALSGANDVVAHEITHGVTQQTANLEYYGQSGALNESFSDIFGYFVD-PSDWLMGEDVYTPGQSGDALRSLSNPGAFGQPENMSQYVNTQS-------D QGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+I Y I+ LG +K++ I+Y +L YLT + FSDA++A+ +A YG A +V ++ AG+ NGGVHINSGIPNKIAYNTIRQLGNQKSEQIYYRALTQYLTSNSNFSDAKNALAQSAYDLYGQNDADIVWNEWSKAGV
Show aligned area	46906435	Listeria monocytogenes str. 4b F2365	zinc metallopeptidase	510	8e-44	0.30	0.51
EQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN------PVDQVVKI-------QSVDAIG--EEGVKKIIASDNP-ETKDLV + + ++D +D G+ H L ++G D+D + +H+ + +T + G+ + +KI ++ +AIG E VK I NP + K+++ KNFKILDMTKDKLGVTHYTLALSSDGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYIG--NPVKEKEII FLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHV--------------GSEVTLKNSFQVA----FNVPVEKSNTGIAL--- + KR L Y +++ + + S + +V+A G I++KQ++ V G+ L+ V V++++ G+ INSRTKR------LVYNIKLIFAEP-EVASWIIQVDAETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRTHKGLIRTFD --HGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKT H TD + + VV K N + P +AVDA+ + V YY++ Q S+D +G I S V + +NAFWDG+ + YG+ K LNHKTDAS--FGKVVSNKTN--MFTDPEF----SSAVDAHFYASEVYDYYKNVHQLESLDGKGGEIDSFV--HYGLNCNNAFWDGREILYGDGDKKNFKP YASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTG-IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGG ++ + +VGHE+TH V +++AGLEY GQSGALNES++D+ GY I+ ++ IG D + G IR+++ P K+ Q M Y+ T D GG FSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIA-PNHWLIGEDVCVRGLRDGRIRSIKDPDKYNQAAHMKDYES---LPITEEGDWGG VHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI VH+NSGI N+ Y I LG EK + +++ +L YLT KAQF+DA+ A+ AAK YG++A+ V+ A+ + G+ VHFNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKAQFTDAKKALQQAAKDLYGEDASKKVAEAWEAVGV
Show aligned area	154685888	Bacillus amyloliquefaciens FZB42	NprE	521	9e-44	0.31	0.49
ESEVSTVLSKLEKEAISEAA-------AEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN----------PVDQVVKIQSVD +SE+ +V K K+ + + +E+ ++D D G KH + GV V VIIH+D++ V ++ G ++ Q++D QSELPSVSDKAIKQYLKQNGKVFKGNPSERLKLIDHTTDDLGYKHFRYVPVVNGVPVKDSQVIIHVDKSNNVYAINGELNNDASAKTANSKKLSANQALD ----AIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEH---VGSEVTLKNSFQVAFNVPVE AIG+ + +++ N K+ L + + +L Y V + +P + V+A G +++KQ+ EH G+ TLK V+ N+ E HAFKAIGKS--PEAVSNGNVANKNKAELKAAATKDGKYRLAYDVTIRYIEP-EPANWEVTVDAETGKVLKKQNKVEHAAATGTGTTLKGK-TVSLNISSE KSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDG S + + TG D +N + +LV+ N AVDA+ + V Y+ F+R+S D++G I+S V + Y+NA W G -SGKYVMRDLSKPTGTQIITYDLQNRQYNLPG-TLVSSTTNQFTTSSQRAAVDAHYNLGKVYDYFYQTFKRNSYDNKGGKIVSSV--HYGSKYNNAAWIG KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDD M YG+ + S+DV HEMTHGVT+ TA L Y Q GALNES+SD+ GY + + +IG D + +R+L TP+K+GQP+ Y + DQMIYGDGDGSFFSPLSGSMDVTAHEMTHGVTQETANLNYENQPGALNESFSDVFGYF-NDTEDWDIGEDITV--SQPALRSLSTPTKYGQPD---HYKN RARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI T D GGVH NSGI N+ Y I +G++KA+ I+Y +L YLTP + F DA+ A++ +A+ YG + A+ V AA+N+ G+ YQNLPNTDAGDYGGVHTNSGIPNKAAYNTITKIGVKKAEQIYYRALTVYLTPSSNFKDAKAALIQSARDLYGSQDAASVEAAWNAVGL
Show aligned area	217965711	Listeria monocytogenes HCC23	zinc metalloproteinase aureolysin	510	1e-43	0.31	0.50
EQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKI-------------QSVDAIG--EEGVKKIIASDNP-ETKDLV + + ++D +D G+ H L + G D+D + +H+ + +T + G+ +KI ++ +AIG E VK I NP + K+++ KNFKILDMTKDKLGVTHYTLALSSGGYLTDNDEIKVHVTPDNKITFINGDLQQGQLKITNQIKMTEKNAIEKAFEAIGQSEAHVKSYIG--NPVKEKEII FLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHV--------------GSEVTLKNSFQVA----FNVPVEKSNTGIAL--- + KR L Y +++ + + S + +V+A G I++KQ++ V G+ L+ V V++++ G+ INSRTKR------LVYNIKLIFAEP-EVASWIIQVDAETGAILKKQNMLSEVEPADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRTHKGLIRTFD --HGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKT H TD + + VV K N + P +AVDA+ + V YY++ Q S+D +G I S V + +NAFWDG+ + YG+ K LNHKTDAS--FGKVVSNKTN--MFTDPEF----SSAVDAHFYASEVYEYYKNVHQLESLDGKGGEIDSFV--HYGLNCNNAFWDGREILYGDGDKKNFKP YASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTG-IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGG ++ + +VGHE+TH V +++AGLEY GQSGALNES++D+ GY I+ ++ IG D + G IR+++ P K+ Q M Y A T D GG FSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIA-PNHWLIGEDVCVRGSRDGRIRSIKDPDKYNQAAHMKDY---ASLPITEEGDWGG VHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI VH+NSGI N+ Y I LG EK + +++ +L YLT KAQF+DA+ A+ AAK YG++A+ V+ A+ + G+ VHFNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKAQFTDAKKALQQAAKDLYGEDASKKVAEAWEAVGV
Show aligned area	16802249	Listeria monocytogenes EGD-e	Zinc metalloproteinase precursor	510	5e-43	0.30	0.50
EQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN------PVDQVVKIQSVDAIGEEGVKKIIASD--------NP-ETKDLVF + + ++D +D G+ H L + G D+D + +H+ + +T + G+ + +KI +AI E+ + I S+ NP + K+++ KNFKILDMTKDKLGVTHYTLALSSGGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAI-EKAFEAIGQSEAHVKSYVGNPVKEKEIIL LAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHV--------------GSEVTLKNSFQVA----FNVPVEKSNTGIAL---- + KR L Y +++ + + S + +V+ G I++KQ++ V G+ L+ V V++++ G+ NSRTKR------LVYNIKLIFAEP-EVASWIVQVDVETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRTHKGLIRTFDL -HGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTY H TD + + VV K N + P +AVDA+ + V YY++ Q S+D +G I S V + +NAFWDG+ + YG+ K + KHNTDTS--FGKVVSNKTN--MFTDPEF----SSAVDAHFYASEVYEYYKNVHQLESLDGKGGEIDSFV--HYGLNCNNAFWDGQEILYGDGDKKNFKPF ASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTG-IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGV + + +VGHE+TH V +++AGLEY GQSGALNES++D+ GY I+ ++ IG D + G IR+++ P K+ Q M Y+ T D GGV SCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIA-PNHWLIGEDVCVRGSRDGRIRSIKDPDKYNQAAHMKDYESLPL---TEEGDWGGV HYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI HYNSGI N+ Y I LG EK + +++ +L YLT K+QF+DA+ A+ AAK YG++A+ V+ A+ + G+ HYNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKSQFTDAKKALQQAAKDLYGEDASKKVAEAWEAVGV
Show aligned area	16078534	Bacillus subtilis subsp. subtilis str. 168	extracellular neutral metalloprotease	521	1e-42	0.31	0.48
AEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQ-VVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEG-- +++ +V+ DA G KH + GV + VI+H+D++ V +V G +Q K + + E + ++ D V K N SKRLKLVESTTDALGYKHFRYAPVVNGVPIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAVSNGAAKNSNKAELK ---------QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEH---VGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSI +L Y V + +P + V+A G+I+++Q+ EH GS TLK + V N+ E + + TG D +N S AIETKDGSYRLAYDVTIRYVEP-EPANWEVLVDAETGSILKQQNKVEHAAATGSGTTLKGA-TVPLNISYEGGKY-VLRDLSKPTGTQIITYDLQNRQSR IQAP--------SLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHG + + + AVDA+ + V Y+ +F+R+S D++G I+S V + Y+NA W G M YG+ + SLDV HEMTHG LPGTLVSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSV--HYGTQYNNAAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHG VTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTII VT+ TA L Y Q GALNES+SD+ GY + + +IG D + +R+L P+K+ QP+ A Y + T D GGVH NSGI N+ Y I VTQETANLIYENQPGALNESFSDVFGYF-NDTEDWDIGEDITV--SQPALRSLSNPTKYNQPDNYANYRN---LPNTDEGDYGGVHTNSGIPNKAAYNTI QNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI LG+ K+Q I+Y +L YLTP + F DA+ A++ +A+ YG A+ V AA+N+ G+ TKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTDAAKVEAAWNAVGL
Show aligned area	161510843	Staphylococcus aureus subsp. aureus USA300_TCH1516	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	87160020	Staphylococcus aureus subsp. aureus USA300	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	151222748	Staphylococcus aureus subsp. aureus str. Newman	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	57652377	Staphylococcus aureus subsp. aureus COL	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	49487416	Staphylococcus aureus subsp. aureus MSSA476	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	21284287	Staphylococcus aureus subsp. aureus MW2	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	15928223	Staphylococcus aureus subsp. aureus N315	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKHKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	15925627	Staphylococcus aureus subsp. aureus Mu50	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKHKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	156980952	Staphylococcus aureus subsp. aureus Mu3	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKHKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	148269070	Staphylococcus aureus subsp. aureus JH9	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKHKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	150395151	Staphylococcus aureus subsp. aureus JH1	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKHKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	82752218	Staphylococcus aureus RF122	zinc metalloproteinase aureolysin	509	2e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	88196592	Staphylococcus aureus subsp. aureus NCTC 8325	zinc metalloproteinase aureolysin	498	3e-42	0.30	0.47
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK----K +V +S+ L +L K + + Y V D K D G H L+ +GV V +H D++G V + G+ + VK + + ++ K EVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFK IIASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y V + + T + K++A G I+EK +L + K ++ + + G +L AVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELITV-TPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAVV----DGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V Q A VDA + K YY+D F R S D++G PI+S+ + D +NA W G M YG+ T HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVFTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	49484834	Staphylococcus aureus subsp. aureus MRSA252	zinc metalloproteinase aureolysin	509	4e-42	0.30	0.48
QVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK-IQSVDAIGEEGVKKI-- ++ +S+ L +L K + + Y+V D K D G H L+ +GV V +H D++G V + G+ + VK V +E K EITQKSDAVKALKELPKSENVKNHYQDYSVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDEAADKAFN -IASDNPETKDLVFLAI-DKRVNNEG---QLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTD + D + K+L I + +V +G + Y + + + T + K++A G ++EK +L + + T K ++ + + G +L AVKIDKNKAKNLQDDVIKENKVEIDGDSNKYIYNIELITV-TPEISHWKVKIDADTGAVVEKTNLVKEAAATGTGKGVLGDTKDININSIDGGFSLEDLT NTGVYHAV----VDGKNNYSIIQAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH---PDAYDNAFWDGKAMRYGETSTPTG + G A G+ + + V +Q A VDA + K YY++ F R S D+ G PI+S+ H D +NA W G M YG+ T HQGKLSAYNFNDQTGQATLITNEDENFVKDDQRAGVDANYYAKQTYDYYKNTFGRESYDNHGSPIVSLTHVNHYGGQDNRNNAAWIGDKMIYGDGDGRTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ + + DVV HE+THGVT+ TA LEY QSGALNES+SD+ GY + + +G D + ++ +R++ P + GQP M Y + D TNLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDD-EDFLMGEDVYTPGKEGDALRSMSNPEQFGQPSHMKDYVYTEK-------DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI GGVH NSGI N+ Y +IQ +G K++ I+Y +L YLT + F D +DA+ AAK Y ++ A V A+N G+ GGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Show aligned area	73662851	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	putative zinc metalloprotease	520	5e-41	0.31	0.50
ISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN------PVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAI + + A EQY + D+++D G+ H L+ + G+T + + +H+++ G VT + G+ VD VKI +VDA E K I + + ++ I VQDNAFEQYEITDKQQDPTGITHYTLKPKVNGITAEDSALKVHVNKQGDVTLINGSIDKPTVKVDNEVKISAVDA--ENSAFKAIGKNKADVNNIKGYDI DKR----VNNEGQ-LFYKVRVTS-SPTGDPVSLVYKVNATDGTIMEKQD-----------------------LTEHVGSEVTLKNSFQVAFNVPVEKSNT + +N++ Q L Y V + SP + +V+A+ G I+ K++ LTE+ G E TLK++ Q A + +T VNKNKLDINSDSQKLVYDVELNYISPKAAHWKI--QVDASTGEILNKENVIKNASATGKGTGVNDDEKSPLNLTENNG-EYTLKDTTQNA------EMHT GIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTG A + TD+ + + + NN+ + ++ VDA+ + V YY D R S D+ G I SVV + Y+NA W G+ M YG+ T QTANNTTDD---FSEITNDSNNFDKEE-------HKAGVDAHYYANEVYNYYLDKHHRDSYDNAGGKIDSVV--HYDKDYNNAAWTGQYMIYGDGDGQTF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQ K + + D++ HE+TH VTE T+ L+Y QSGALNES+SD+ GY + + +G D + + G+R+L+ P ++ QP M Y D++ + D KALSGANDIIAHELTHAVTERTSNLKYQDQSGALNESFSDVFGYFVD-PDDWLMGEDVYTPGTEGDGLRSLKDPERYNQPAHM--YQDQSGSQ-----DN GGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAAS--VVSAAFNSAGI GGVH NSGI N+ Y I +G +KA+ I+Y +L YLT ++FSDA+ A+ AA YGD +A + A+ G+ GGVHTNSGIPNKAAYLTINEIGKDKAEQIYYLALTQYLTQNSEFSDAKTALKEAANKLYGDNSAEADAIDKAWTEVGV
Show aligned area	15895782	Clostridium acetobutylicum ATCC 824	extracellular neutral metalloprotease, NPRE	557	2e-39	0.29	0.48
SESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKIIASDNP +E + L + + + ++ + A + ++ D G+ +K+ + +G + +I+HLD++G V ++ G V++ K + + A +GV A NEQSILAYLEQNKSQFLNVSGANNFKILSIDTDELGLTKVKVAQTVDGTPIRGSQIILHLDKDGVVKNIIG-AVNKDYK-RPLFAARSQGVTATQAISIA ETKDLVFLAIDKRVNNEGQLFYKVRVTSS------PTGDPVSLVYKV--NATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTG + K F ++ + + Q+ K V ++ DP ++V +A G I+ D E+ G T K + + P+ TG D T K-KQFSFKSLVEAPRAQKQVIVKNGVATTVYSVNIHYNDPDIANWEVLIDANSGKIVRTLDKIEYDGP-ATGKGTAVDGTSKPLNLYLTGSTYQLIDTTK VYHAVVDG--KNNY-----SIIQAPSLVALNQNA---VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGK + NN +++ + S + N+ A V A+ + V +Y++ R+SID GM I+S + +YDNA+WDG M YG+ AMTGKIKTYTANNREVEPGTLVTSKSNIFTNEAAKAEVSAHYYAGVVYDFYKNVLGRNSIDGNGMNIISTA--HYGQSYDNAYWDGSQMVYGDGDGSEFT TYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS---------------GASNPEIGADTQSVDRKT--GIRNLQTPSKHGQPETMAQ ++ LDVVGHE+THGVT++TA L Y QSGALNES SD+ G +I AS+ +G D ++ T +R+L P+ + QP+ M YFSGDLDVVGHELTHGVTQYTANLNYEDQSGALNESMSDVFGVLIQTYDKYNVKNGGNWAFSASDWVVG-DGLFLNNTTHRALRSLANPTLYDQPDNMNN YDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKED Y + + D GGVH NSGI N+ Y + ++LG K I+Y +L NYLT A FS AR+A+ +AA YG ++ V +AF++ G+ + D YVNTSD-------DNGGVHTNSGIPNKAAYLVAKSLGTNKTAHIYYRALTNYLTSDADFSSARNALESAASDLYGSSGSNAVDSAFDNVGVSSNSD
Show aligned area	67078236	Bacillus cereus E33L	neutral protease	556	4e-39	0.32	0.45
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN---------PVDQVVKIQSVDA ++++V ++ V L + KE T+ + K D GMKH + V VD I+H D+ G VT+V G+ D KI A SDKKVETQKAVKEFLEE-NKELFKVNPQTDLTLKEVKSDDLGMKHYVYTRSVNKVPVDGAQFIVHTDKEGKVTTVNGDVHPSAAENLKGDTEAKITKETA IG----------------EEG-----VKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEH------- + E+G VK+ + S N E DLV D E L +KV++ +Y VNA DG I++ + LSSAWKHIKLTKNDTLVKEDGNTLDQVKENLESTN-EKADLVVYEKD----GEYYLTFKVQLQFIKPYGANWQIY-VNAEDGKIIDSYNAVTDAESAQKG -----VGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNT-GVYHAVVDGKNNYSIIQAPSLVALNQN---AVDAYTHGKFVKTYYEDHFQRHSIDDRGMP +G L +F K T G T V H+ D NY ++ + +N+N AVDA+ H V YY++ R+SID +G YGQGVLGDRKELNTTFDSVKGKYYLKDTTKPMNGGYIETFTVNHSDADYPVNYRLLDDDN-AWINKNQGPAVDAHYHAGKVYDYYKNIHNRNSIDGKGKT ILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTG I S V+ + +NAFW+G+ M YG+ + SLDVV HE+TH VT+++A L Y+ QSGALNES+SD+ GY + +N ++G + IRSGVN--YGVNVNNAFWNGQQMIYGDGDGRIFSPLSGSLDVVAHELTHAVTQYSADLRYVNQSGALNESFSDVFGYFVD-PTNWDLGEAVYTPGISGDA IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAML--AAAKVQYGDEAAS +R+L P K+GQP M Y T D GGVH NSGI N+ Y I +G EKA+ I+Y +L YLTP + F AR A+L AA YG LRSLSNPEKYGQPSHMRDYQ---YLPATEEGDNGGVHINSGIPNKAAYLTINAIGKEKAEKIYYRALTTYLTPTSDFKQARTALLQSAADYDGYGSATYK VVSAAFNSAGI V A+N G+ AVENAWNQVGV
Show aligned area	15895558	Clostridium acetobutylicum ATCC 824	ChW repeat-containing metalloprotease	836	7e-39	0.29	0.50
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN--PVDQVVKIQSVDAIGEEGVK ++++V SE E + L ++ ++A + + K+D+ G ++ + GV+V + +H D+NG V SV G V ++ ++ E+ V SKKKVPSEKEATQFLEDNKQIFGIDSAQNELKPISTKKDSNGDTFVRFNQVINGVSVKDRILNVHFDKNGTVVSVNGTIEKNKTVTRLGNISINEEDAVN KIIASDNPETKDLVFLAIDKRV--NNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEV-TLKNSFQVAFNVPVEKSNTGIALHGT + +T + AI + NN+ +KV + ++PT + V+ + G +++ ++ ++ G + T + + + +S + + IALKQFTYKTLENTPKAIKTILTDNNKNYEVFKVNIYYTNPTIGNWDVF--VDISSGKVIKTENNIKYDGKVLGTGIDVSGTTRTLNLYQSGSSYQMKDI DNTGVYHAVVDGKNNYSIIQ---APSLVALNQN----AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTG N+ + NN +++ + S NQ AV A+ + V +Y++ F R+S+D+ M I S + Y+NAFWDG+ M YG+ SNSAASYINTYSYNNTTLLGTLVSNSTSNFNQESHKAAVSAHYNAGKVINFYKNLFNRNSLDNNSMAIKSYT--HYGKNYNNAFWDGQEMIYGDGDGLNF KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS------------NPE---IGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ + LDVVGHEMTHGV E+TA L Y + GALNES +D G +I + NP IG D + K +R+L P+ + QP+ M+ TYLSGDLDVVGHEMTHGVIENTANLNYDNEQGALNESIADTFGVLIETYTKYNVAAGGTWQINPSDWVIGDDIYTPQIKGDALRSLVNPALYDQPDNMSG YDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGAKEDIQ Y++ + D GGVH NSGI N+ Y I Q++G+EK I+Y +LVNY+TP F++AR+ ++ +A YG +A V V+ AF++ GIG +++ YENLPDNEAG---DFGGVHTNSGITNKAAYLIAQSIGMEKTARIYYRALVNYMTPTTDFNEARNVLVESAVDLYGGGSAEVAAVNNAFDTVGIG--QNLA VNQPS V PS VATPS
Show aligned area	152975941	Bacillus cereus subsp. cytotoxis NVH 391-98	peptidase M4 thermolysin	556	1e-38	0.31	0.46
TVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN---PVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFY T+ + K D GMKH + V VD +IH ++ G VT+V GN + V+ + I +E A+ + K + D V G + TLKEVKSDDLGMKHYVYTQSINKVPVDGARFMIHTNKEGKVTTVNGNIHPDAAENVRKNTTAKISKE------AALSNAWKHINLTKNDTLVEGNGNVLD KVRVTSSPTGDPVSLVYK---------------------------VNATDGTIMEKQDLTEH------------VGSEVTLKNSFQVAFNVPVEKSNTGI KV+ T + LV VNA DGTI++ + +G L ++ + T KVKDNLESTSEKADLVVYEKEGKYYLTFKVQLQFVKPYGANWQIYVNAEDGTIVDSYNAVTDADIAKKGYGYGVLGDRKELNTTYNSTKGKYYLRDMTKP ALHGTDNT-GVYHAVVDGKNNYSIIQAPSLVALNQN---AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTP G T V H+ D NY ++ + +N+N AVDA+ H V YY++ R+SID +G I S V+ + +NAFW+G+ M YG+ MNGGVIETFTVNHSDADYPVNYYLLDDDN-AWINKNQRPAVDAHYHAGKVYDYYKNIHNRNSIDGKGKTIRSAVN--YGTNVNNAFWNGQQMIYGDGDGY TGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQYDDRARYKGTPY + SLDVV HE+TH VT+++A L+Y+ QSGALNES+SD+ GY + +N ++G + R G +R+L P K+GQP M Y T EFIPLSGSLDVVAHELTHAVTQYSADLQYVNQSGALNESFSDVFGYFVD-PNNWDLG-EAVYTPRVAGDALRSLSDPEKYGQPAHMKDYQ---FLPPTEE YDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAAS--VVSAAFNSAGI D GGVH NSGI N+ Y I +G EKA+ I+Y +L YLTP + F AR A+L +A G ++A+ V A+N GI GDNGGVHINSGIPNKAAYLTINAIGKEKAEKIYYRALTTYLTPTSNFKQARAALLQSAADYDGYDSATYKAVENAWNQVGI
Show aligned area	152975387	Bacillus cereus subsp. cytotoxis NVH 391-98	peptidase M4 thermolysin	556	2e-38	0.31	0.43
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN--PV-------DQVVKIQS--- + ++V S+ V L + KE T+ + K D GMKH + V VD ++H D+ G VT+V G+ P D KI SNKKVESQKAVKEFLEE-NKELFKINPQTDLTLKEVKSDDLGMKHYVYTRSVNKVPVDGAQFVVHTDKEGKVTTVNGDIHPAAEENLKGDTKAKITKETA ------------------VDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEH------- VD + VK+ + S N E DLV D L +KV++ +Y VNA DGTI++ + LSNAWKHIKLTKNDTLVKVDGNTLDQVKENLESTN-EKADLVVYEKDGTY----YLAFKVQLQFIKPYGANWQIY-VNAEDGTIIDSYNAVTDADSPRKG -----VGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNT-GVYHAVVDGKNNYSIIQAPS--LVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPI +G L +F K T G T V H+ D NY + + + + AVDA+ H V YY++ R+S D +G I YGYGVLGDRKELNTTFDSVKGKYYLKDTTKPMNGGYIETFTVNHSNADYPVNYRLWDDDNAWINKEQRPAVDAHYHAGKVYDYYKNVHNRNSFDGKGKTI LSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS--------NPEIGADTQS S V+ + +NAFW+G+ M YG+ + SLDVV HE+TH VT+++A L Y+ QSGALNES+SD+ GY + A+ P I D RSGVN--YGVNVNNAFWNGQQMVYGDGDGRVFAPLSGSLDVVAHELTHAVTQYSADLRYVNQSGALNESFSDVFGYFVDPANWDLGEAVYTPGISGD--- VDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAML--AAAKVQY +R+L P K+GQP M Y T D GGVH NSGI N+ Y I +G EKA+ I+Y +L YLTP + F AR A+L AA Y -----ALRSLSNPEKYGQPSHMRDYQ---YLPATEEGDNGGVHINSGIPNKAAYLTINAIGKEKAEKIYYRALTTYLTPTSDFKQARTALLQSAADYDGY GDEAASVVSAAFNSAGI G V A+N G+ GSATYKAVETAWNQVGV
Show aligned area	221642229	Bacillus cereus Q1	protease	556	2e-38	0.31	0.45
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTG------------NPVDQVVK--- ++++V ++ V L + KE T+ + K D GMKH + V VD I+H D+ G VT+V G N ++ K SDKKVETQKAVKEFLEE-NKELFKVNPQTDLTLKEVKSDDLGMKHYIYTRSVNKVPVDGAQFIVHTDKEGKVTTVNGDVHPAAAESLKGNTKAKITKETA ---------------IQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEH------- + VD + VK+ + S N E DLV D + L +KV++ +Y VNA +G+I++ + LSNAWKHIKLTKNDTLIKVDGNTLDQVKENLESTN-EKADLVVYEKDGKY----YLTFKVQLQFIKPYGANWQIY-VNAENGSIIDSYNAVTDADSPQKG -----VGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNT-GVYHAVVDGKNNYSIIQAPSLVALNQN---AVDAYTHGKFVKTYYEDHFQRHSIDDRGMP +G L +F K T G T V H+ D NY ++ + +N++ AVDA+ + V YY++ R+SID +G YGYGVLGDRKELNTTFDSVKRKYYLKDTTKPMNGGYIETFTVNHSDADYPVNYRLLDDDN-AWINKDQGPAVDAHYNAGKVYDYYKNIHNRNSIDGKGKT ILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS--------NPEIGADTQ I S V+ + +NAFW+G+ M YG+ + SLDVV HE+TH VT+++A L Y+ QSGALNES+SD+ GY + A+ P I D IRSGVN--YGVDVNNAFWNGQQMIYGDGDGREFIPLSGSLDVVAHELTHAVTQYSADLRYVNQSGALNESFSDVFGYFVDPANWDLGEAVYTPGISGD-- SVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAML--AAAKVQ +R+L P K+GQP M Y T D GGVH NSGI N+ Y I +G EKA+ I+Y +L YLTPK+ F AR A+L AA ------ALRSLSNPEKYGQPSHMKDYQ---YLPATEEGDNGGVHINSGIPNKAAYLTINAIGKEKAEKIYYRALTTYLTPKSDFKQARTALLQSAADYDG YGDEAASVVSAAFNSAGI YG A V A+N G+ YGSAAYKAVEDAWNQVGV
Show aligned area	217956957	Bacillus cereus AH187	neutral protease	556	3e-38	0.31	0.45
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTG------------NPVDQVVK--- ++++V ++ V L + KE T+ + K D GMKH + V VD I+H D+ G VT+V G N ++ K SDKKVETQKAVKEFLEE-NKELFRVNPQTDLTLKEVKSDDLGMKHYIYTRSVNKVQVDGAQFIVHTDKEGKVTTVNGDVHPAAAESLKGNTKAKITKETA ---------------IQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEH------ + VD + VK+ + S N ET DLV D + L +KV++ P G + VNA +G+I++ + LLNAWKHIKLTKNDTLIKVDGNTLDQVKENLESTN-ETADLVVYEKDGKY----YLTFKVQLQFIKPYGANWQIY--VNAENGSIIDSYNAVTDADSSQK ------VGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNT-GVYHAVVDGKNNYSIIQAPSLVALNQN---AVDAYTHGKFVKTYYEDHFQRHSIDDRGM +G L +F K T G T V H+ D NY ++ + +N++ AVDA+ + V YY++ R+SID +G GYGYGVLGDRKELNTTFDSVKRKYYLKDTTKPMNGGYIETFTVNHSDADYPVNYRLLDDDN-AWINKDQGPAVDAHYNAGKVYDYYKNIHNRNSIDGKGK PILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS--------NPEIGADT I S V+ + +NAFW+G+ M YG+ + SLDVV HE+TH VT+++A L Y+ QSGALNES+SD+ GY + A+ P I D TIRSGVN--YGVDVNNAFWNGQQMIYGDGDGREFIPLSGSLDVVAHELTHAVTQYSADLRYVNQSGALNESFSDVFGYFVDPANWDLGEAVYTPGISGD- QSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAML--AAAKV +R+L P K+GQP M Y T D GGVH NSGI N+ Y I +G EKA+ I+Y +L YLTP + F AR A+L AA -------ALRSLSNPEKYGQPSHMKDYQ---YLPATEEGDNGGVHINSGIPNKAAYLTINAIGKEKAEKIYYRALTTYLTPTSDFKQARTALLQSAADYD QYGDEAASVVSAAFNSAGI YG A V A+N G+ GYGSAAYKAVEDAWNQVGV
Show aligned area	27469137	Staphylococcus epidermidis ATCC 12228	zinc metalloproteinase aureolysin	507	4e-38	0.29	0.47
EEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK--- + +V ES+ + L +L K + + Y V D ++D G H L+ + V +H ++ G V V G+ + V+ + AI +E DAKVTQESQATNALKELPKSENIKKHYKDYKVTDTEKDNKGFTHYTLQPKVGNTYAPDKEVKVHTNKEGKVVLVNGDTDAKKVQPTNKVAISKESATDKA -KIIASDNPETKDLVFLAID-KRVNNEGQ---LFYKVRV-TSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALH + I D + K+L I +V +G+ Y + + T+SP ++ K++A G +++K ++ + + T K + + + G AL FEAIKIDRQKAKNLKSDVIKTNKVEIDGEKNKYVYNIEIITTSPKISHWNV--KIDAETGQVVDKLNMIKEAATTGTGKGVLGDTKQININSVSGGYALQ GTDNTGVYHAV-VDGKNNYSII---QAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV---DEQHPDAYDNAFWDGKAMRYGETST G A D + + + + V Q A VDA + K YY++ F R S D++G PI+S+ + Q D +NA W G M YG+ DLTQQGTLSAYNYDANTGQAYLMQDKDKNFVDDEQRAGVDANYYAKETYDYYKNTFGRESYDNQGSPIISIAHVNNFQGQDNRNNAAWIGDKMIYGDGDG PTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS--------NPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRA T + + DVV HE+THGVT+ TA L Y QSGALNES+SD+ GY I P +G D +R++ P + GQP M + RTFTALSGANDVVAHEITHGVTQQTANLVYRSQSGALNESFSDVFGYFIDDEDFLMGEDVYTPGVGGD--------ALRSMSNPERFGQPSHMNDF---- RYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI Y + D GGVH NSGI N+ Y I+++G ++++ I+Y +L YLT + F DA+ ++ AA YGD A V A++S G+ VYTNS---DNGGVHTNSGIPNKAAYNTIRSIGKQRSEQIYYRALTVYLTSNSDFQDAKASLQQAAFDLYGDGIAQQVGQAWDSVGV
Show aligned area	118478539	Bacillus thuringiensis str. Al Hakam	neutral protease	576	1e-37	0.30	0.46
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTG------------NPVDQVVK--- ++++V ++ V L + KE + T+ + K D GMKH + + VD I+H D+ G VT+V G N ++ K SDKKVETQKAVKEFLEE-NKELFKINPQKDLTLKEVKSDDLGMKHYVYTRSINKIPVDGAQFIVHTDKEGKVTTVNGDVHPAAEESLKGNTKAKITKETA ---------------IQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEH------- + +D + +K+ + S N ET DLV D L +KV++ +Y VNA DGTI++ + LSNAWKHIKLTKSDTLVKMDGNALDQIKENLESTN-ETADLVVYEKDGTY----YLTFKVKLQFIKPYGANWHIY-VNAEDGTIVDSYNAVTDADSAHKG -----VGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNT-GVYHAVVDGKNNYSIIQAPSLVALNQN---AVDAYTHGKFVKTYYEDHFQRHSIDDRGMP +G + L +F K T G T V H+ D NY + + +N++ AVDA+ + V YY++ R+SID +G YGYGVLGDKKELNTTFSSVKGKYYLKDTTKPMNGGYIETFTVNHSDEDYPINYRLFDEDN-AWINKDQRPAVDAHYYAGKVYDYYKNVHNRNSIDGKGKT ILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTG- I S V+ + +NAFW+G+ M YG+ + SLDVV HE+TH VTE++A L Y+ QSGALNES+SD+ GY + +N ++G D +G IRSAVN--YGVNVNNAFWNGQQMIYGDGDGRRFIPLSGSLDVVAHELTHAVTEYSADLRYVNQSGALNESFSDVFGYFVD-PTNWDVG-DAVFTPGVSGD -IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAAS- +R+L P K+GQP M Y T D GGVH NSGI N+ Y I ++G EKA+ I+Y +L YLTP + F AR A+L +A G ++ + ALRSLSNPEKYGQPAHMRNYQ---YLPETEEGDNGGVHINSGIPNKAAYLTINSIGKEKAEKIYYRALTIYLTPTSDFKQARTALLQSAADYDGYDSVTY -VVSAAFNSAGI + A+N G+ KAIENAWNQVGV
Show aligned area	57865650	Staphylococcus epidermidis RP62A	extracellular elastase precursor	507	1e-37	0.29	0.47
EEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVK--- + +V ES+ + L +L K + + Y V D ++D G H L+ + V +H ++ G V V G+ + V+ + AI +E DAKVTQESQATNALKELPKSENIKKHYKDYKVTDTEKDNKGFTHYTLQPKVGNTYAPDKEVKVHTNKEGKVVLVNGDTDAKKVQPTNKVAISKESATDKA -KIIASDNPETKDLVFLAID-KRVNNEGQ---LFYKVRV-TSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALH + I D + K+L I +V +G+ Y + + T+SP ++ K++A G +++K ++ + + T K + + + G L FEAIKIDRQKAKNLKSDVIKTNKVEIDGEKNKYVYNIEIITTSPKISHWNV--KIDAETGQVVDKLNMIKEAATTGTGKGVLGDTKQININSVSGGYTLQ GTDNTGVYHAV-VDGKNNYSII---QAPSLVALNQNA-VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV---DEQHPDAYDNAFWDGKAMRYGETST G A D + + + + V Q A VDA + K YY++ F R S D++G PI+S+ + Q D +NA W G M YG+ DLTQQGTLSAYNYDANTGQAYLMQDKDKNFVDDEQRAGVDANYYAKETYDYYKNTFGRESYDNQGSPIISIAHVNNFQGQDNRNNAAWIGDKMIYGDGDG PTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS--------NPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRA T + + DVV HE+THGVT+ TA L Y QSGALNES+SD+ GY I P +G D +R++ P + GQP M + RTFTALSGANDVVAHEITHGVTQQTANLVYRSQSGALNESFSDVFGYFIDDEDFLMGEDVYTPGVGGD--------ALRSMSNPERFGQPSHMNDF---- RYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI Y + D GGVH NSGI N+ Y I+++G ++++ I+Y +L YLT + F DA+ ++ AA YGD A V A++S G+ VYTNS---DNGGVHTNSGIPNKAAYNTIRSIGKQRSEQIYYRALTVYLTSNSDFQDAKASLQQAAFDLYGDGIAQQVGQAWDSVGV
Show aligned area	170756071	Clostridium botulinum B1 str. Okra	thermolysin metallopeptidase	573	3e-34	0.29	0.44
MKGNKILYILGTGIFVGSSCLFSSLFVAAEEQVYSESEVSTVLSKLEK------EAISEAAAEQYTVVD---------------RKEDAWGMKHLKLEK- MK K+L IL + I SS SS++ A + S+ + T EK ++++ A+E++ + +K K LK EK MKSKKLLTILLSAIITASS--ISSVYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSVTNIASEKFNNFEEINQFFQQNISRFGLKKGSLKSTKTLKDEKG --------QTEGVTVDSDNVIIHLDRNGAVTSVTGNPVD---------QVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNN-EGQLFYKVRV Q EG+ V ++ +++ ++S+ G VD +K+ DA+ + A +N + ++L D + N EG+ + V KIHYHTIYQVEGIPVYYGRIVFTTEKDSTISSINGG-VDISFENENWKNKIKLSKNDAMAK-------AKNNIKYEELHASKADLYLYNFEGKPYVVYLV TSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHG-------------------TDNTGVYHAVVDGKNNY--- S ++ VNA DG+I+ K + T + + K + N V KSN I + G T G Y+ KN Y DLSTDAGDWNIF--VNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNKSNNLIDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYIYD -----------SIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETSTPTGK +++A SLV N N AVD Y + + YY+D F R+SID++GM + + VD +A +A W + +M +G INNKYIGYTKSDLLRASSLVENNSNEFTNDKHIIAVDTYINLEKTYDYYKDKFNRNSIDNKGMKVEAFVDY---NAVGDAAWSEEFNSMFFGNGDGKNFA TYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARY-KGTPYYDQ + SLD+VGHE +HGVT + L+Y +SGALNES+SD+MG I G N ++G D+ + + IR++Q PSK GQP M Y RY TP D HMSKSLDIVGHEFSHGVTHKESNLKYENESGALNESFSDIMGVAIKG-KNFKLGEDSWKPNTEEAAIRDMQYPSKRGQPAHMKDY----RYMPATPMGDN GGVHYNSGIINRIGYTI---IQNLGIEKAQTI----FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA GGVH NSGIIN Y I I+ LG+E ++ I FY++ FS R+ ++ K YG+ + +V AF+ GI A GGVHLNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKNLYGENSKYVQIVENAFDKVGITA
Show aligned area	67077983	Bacillus cereus E33L	neutral protease, N-terminal region	274	7e-34	0.40	0.56
HGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG +G +++T+ +H +SID +G I S V+ D Y N FW+G+ M YG+ + SLDVV HE+TH VT+++A L Y+ QSGALNES+SD+ G NGGYIETFTVNH--SNSIDGKGKTIRSGVN-YGVDVY-NVFWNGQQMIYGDGDGRIFSPLSGSLDVVAHELTHAVTQYSADLRYVNQSGALNESFSDVFG YIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQ Y + A N ++G + D +R+L P K+GQP M Y T D GGVH NSGI N+ Y I +G EKA+ I+Y +L YLTP + YFVDPA-NWDLGETVYTPDISGDALRSLSNPEKYGQPSHMRDYQ---YLPATEEGDNGGVHINSGIPNKAAYLTINAIGKEKAEKIYYRALTTYLTPTSD FSDARDAML--AAAKVQYGDEAASVVSAAFNSAGI F AR A+L AA YG A + A+N G+ FKQARTALLQSAADYDGYGSTAYKAIENAWNQVGV
Show aligned area	217962519	Bacillus cereus AH187	neutral protease B	591	9e-34	0.28	0.47
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN----------PVDQVVKIQSVDAIGEEGVKKIIA---SDNPETKDLVFL + + VV ++DA G H+KL ++ + V + + LD+ V + G P + + + I + ++K + S + KDL KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPAAASISAEQAETIAKADIEKEVGKVKSYDGVKKDLFVY AIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVAFNVPVEKSN-----TGIALHGTDNTGVYHAVVD D L Y V+ + S P Y V+AT+G ++EK + +++ + + SF++A + + N G +H D + + + EKDGNY----YLAYLVKASISKPA-PGYWHYFVDATNGNVIEKYNAVDNITGFGYGVLGARQSFEIAQDTKTGQFNLFDGKRGQGIHTFDAENMNENLFN GKNNY-----SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHE + + +++ S ++ AVDA+ + V YY+ F R+S DD+G ++S V A++NA W+G M YG+ T ++ LDV+GHE LFSQWLGYTGEEVESKSKFFEDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISTV--HVGTAWNNAAWNGVQMMYGDGDGKTFIPLSAGLDVIGHE MTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDR--ARYKGTPYYDQGGVHYNSGII +TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D RY GT D GGVH NS I LTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTA--DNGGVHINSSIN NRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI N+ Y + + +G E + I+Y +L YLT + F R A L +A+ YG + +V V+ A+++ G+ NKAAYLVSEGGDHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKNSKAVQAVTKAYDAVGV
Show aligned area	49187895	Bacillus anthracis str. Sterne	neutral protease B	552	1e-33	0.29	0.47
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPV-----DQVVKIQSVDAIGEEGVKKI-IASDNPETKDLVFLAIDKRVN + + VV ++DA G H+KL ++ + V + + LD+ V + G + + + S+ A E + K I + + K+ + D V KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKELGKVKNYDGVKKDLFVY NEGQLFYKVRVTSSPTGDPVS--LVYKVNATDGTIMEKQDLTEHV---GSEVT-LKNSFQVA-------FNVPVEKSNTGIALHGTDNT----------- + +Y + + P Y V+AT+G ++EK + +H+ G EV + SF++A FN+ K G+ DN EKDGKYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYEVLGARQSFEIAQDEKTGAFNLFDGKRGQGVHTFDADNMDENLFNIFSQW -GVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDV G V+ KN + +A AVDA+ + V YY+ F R+S DD+G ++S V + ++NA W+G M YG+ T + ++ LDV FGYTGLEVESKNKFFDDKA---------AVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSV--HVGENWNNAAWNGVQMMYGDGDGTTFISLSAGLDV VGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDR--ARYKGTPYYDQGGVHYN +GHE+TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D RY GT D GGVH N IGHELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTA--DNGGVHIN SGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNS S I N+ Y + + +G E + I+Y +L YLT + F R A L +A+ YG ++ +V V+ A+++ SSINNKAAYLVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDA
Show aligned area	47778383	Bacillus anthracis str. 'Ames Ancestor'	neutral protease B	547	1e-33	0.29	0.47
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPV-----DQVVKIQSVDAIGEEGVKKI-IASDNPETKDLVFLAIDKRVN + + VV ++DA G H+KL ++ + V + + LD+ V + G + + + S+ A E + K I + + K+ + D V KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKELGKVKNYDGVKKDLFVY NEGQLFYKVRVTSSPTGDPVS--LVYKVNATDGTIMEKQDLTEHV---GSEVT-LKNSFQVA-------FNVPVEKSNTGIALHGTDNT----------- + +Y + + P Y V+AT+G ++EK + +H+ G EV + SF++A FN+ K G+ DN EKDGKYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYEVLGARQSFEIAQDEKTGAFNLFDGKRGQGVHTFDADNMDENLFNIFSQW -GVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDV G V+ KN + +A AVDA+ + V YY+ F R+S DD+G ++S V + ++NA W+G M YG+ T + ++ LDV FGYTGLEVESKNKFFDDKA---------AVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSV--HVGENWNNAAWNGVQMMYGDGDGTTFISLSAGLDV VGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDR--ARYKGTPYYDQGGVHYN +GHE+TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D RY GT D GGVH N IGHELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTA--DNGGVHIN SGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNS S I N+ Y + + +G E + I+Y +L YLT + F R A L +A+ YG ++ +V V+ A+++ SSINNKAAYLVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDA
Show aligned area	30265084	Bacillus anthracis str. Ames	neutral protease B	547	1e-33	0.29	0.47
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPV-----DQVVKIQSVDAIGEEGVKKI-IASDNPETKDLVFLAIDKRVN + + VV ++DA G H+KL ++ + V + + LD+ V + G + + + S+ A E + K I + + K+ + D V KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKELGKVKNYDGVKKDLFVY NEGQLFYKVRVTSSPTGDPVS--LVYKVNATDGTIMEKQDLTEHV---GSEVT-LKNSFQVA-------FNVPVEKSNTGIALHGTDNT----------- + +Y + + P Y V+AT+G ++EK + +H+ G EV + SF++A FN+ K G+ DN EKDGKYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYEVLGARQSFEIAQDEKTGAFNLFDGKRGQGVHTFDADNMDENLFNIFSQW -GVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDV G V+ KN + +A AVDA+ + V YY+ F R+S DD+G ++S V + ++NA W+G M YG+ T + ++ LDV FGYTGLEVESKNKFFDDKA---------AVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSV--HVGENWNNAAWNGVQMMYGDGDGTTFISLSAGLDV VGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDR--ARYKGTPYYDQGGVHYN +GHE+TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D RY GT D GGVH N IGHELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTA--DNGGVHIN SGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNS S I N+ Y + + +G E + I+Y +L YLT + F R A L +A+ YG ++ +V V+ A+++ SSINNKAAYLVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDA
Show aligned area	222098493	Bacillus cereus Q1	neutral protease B	591	1e-33	0.28	0.48
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN----------PVDQVVKIQSVDAIGEEGVKKIIA---SDNPETKDLVFL + + VV ++DA G H+KL ++ + V + + LD+ V + G P + + + I + ++K + S + KDL KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPAAASISAEQAETIAKADIEKEVGKVKSYDGVKKDLFVY AIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVAFNVPVEKSN-----TGIALHGTDNTGVYHAVVD D L Y V+ + S P Y V+AT+G ++EK + +++ + + SF++A + + N G +H D + + + EKDGNY----YLAYLVKASISKPA-PGYWHYFVDATNGNVIEKYNAVDNITGFGYGVLGARQSFEIAQDTKTGQFNLFDGKRGQGIHTFDAENMDENLFN GKNNY-----SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHE + + +++ S ++ AVDA+ + V YY+ F R+S DD+G ++S V ++++NA W+G M YG+ T ++ LDV+GHE LFSQWLGYTGEEVESKSKFFEDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISTV--HVGESWNNAAWNGVQMMYGDGDGKTFIPLSAGLDVIGHE MTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDR--ARYKGTPYYDQGGVHYNSGII +TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D RY GT D GGVH NS I LTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTA--DNGGVHINSSIN NRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI N+ Y + + +G E + I+Y +L YLT + F R A L +A+ YG + +V V+ A+++ G+ NKAAYLVSEGGDHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKNSKAVQAVTKAYDAVGV
Show aligned area	49481084	Bacillus thuringiensis serovar konkukian str. 97-27	neutral protease B	554	1e-33	0.28	0.47
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPV-----DQVVKIQSVDAIGEEGVKKI-IASDNPETKDLVFLAIDKRVN + + VV ++DA G H+KL ++ + V + + LD+ V + G + + + S+ A E + K I + + K+ + D V KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKEVGKVKNYDGVKKDLFVY NEGQLFYKVRVTSSPTGDPVS--LVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVA-------FNVPVEKSNTGIALHGTDNT----------- + +Y + + P Y V+AT+G ++EK + +H+ + + SF++A FN+ K G+ DN EKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYGVLGARQSFEIAQDEKTGAFNLFDGKRGQGVHTFDADNMDENLFNIFSQW -GVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDV G V+ KN + +A AVDA+ + V YY+ F R+S DD+G ++S V + ++NA W+G M YG+ T ++ LDV FGYTGLEVESKNKFFDDKA---------AVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSV--HVGENWNNAAWNGVQMMYGDGDGTTFIPLSAGLDV VGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDRARYKGTPYYDQGGVHYNSG +GHE+TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D + T D GGVH NS IGHELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSS IINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI I N+ Y + + +G E + I+Y +L YLT + F R A L +A+ YG ++ +V V+ A+++ G+ INNKAAYLVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDAVGV
Show aligned area	218906240	Bacillus cereus AH820	neutral protease B	549	1e-33	0.28	0.47
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPV-----DQVVKIQSVDAIGEEGVKKI-IASDNPETKDLVFLAIDKRVN + + VV ++DA G H+KL ++ + V + + +D+ V + G + + + S+ A E + K I + + K+ + D V KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTIDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKEVGKVKNYDGVKKDLFVY NEGQLFYKVRVTSSPTGDPVS--LVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVA-------FNVPVEKSNTGIALHGTDNT----------- + +Y + + P Y V+AT+G ++EK + +H+ + + SF++A FN+ K G+ DN EKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYGVLGARQSFEIAQDEKTGAFNLFDGKRGQGVHTFDADNMDENLFNIFSQW -GVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDV G V+ KN + +A AVDA+ + V YY+ F R+S DD+G ++S V + ++NA W+G M YG+ T ++ LDV FGYTGLEVESKNKFFDDKA---------AVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSV--HVGENWNNAAWNGVQMMYGDGDGTTFIPLSAGLDV VGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDRARYKGTPYYDQGGVHYNSG +GHE+TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D + T D GGVH NS IGHELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSS IINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI I N+ Y + + +G E + I+Y +L YLT + F R A L +A+ YG+++ +V V+ A+++ G+ INNKAAYLVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGEDSKAVQAVTKAYDAVGV
Show aligned area	218233022	Bacillus cereus B4264	neutral protease B	591	2e-33	0.28	0.48
EQYTVVDRKEDAWG-MKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN----------PVDQVVKIQSVDAIGEEGVKKIIA---SDNPETKDLVFL + + +V ++DA H+KL ++ + V + + LD+ V + G P + + + I + ++K I S + KDL KHFNIVGEEKDAESDTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLDDKNIPAAASITAEQAETIAKADIEKEIGKVKSYDGVKKDLFVY AIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVA-------FNVPVEKSNTGIALHGTDNTGV-YHA D L Y V+ + S P Y V+AT+G ++EK + +++ + + SF++A FN+ K G+ +N + EKDGNY----YLAYLVKASISKPA-PGYWHYFVDATNGNVIEKYNAVDNITGFGYGVLGARQSFEIAQDTKTGQFNLFDGKRGQGVHTFDAENMDENWFN VVDGKNNYS--IIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHE + Y+ +++ S ++ AVDA+ + V YY+ F R+S DD+G ++S V ++++NA W+G M YG+ T ++ LDV+GHE LFSQWLGYTGEEVESKSKFFEDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISTV--HVGESWNNAAWNGVQMMYGDGDGKTFIPLSAGLDVIGHE MTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDR--ARYKGTPYYDQGGVHYNSGII +TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + D+ +R+L+ P+ P ++ Y D RY GT D GGVH NS I LTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPDKPGDALRSLKDPASIPNPLKPSEGYPDHYSKRYTGTA--DNGGVHINSSIN NRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI N+ Y + + +G E + I+Y +L YLT + F R A L +A+ YG + +V V+ A+++ G+ NKAAYLVSEGGDHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKNSKAVQAVTKAYDAVGV
Show aligned area	218900191	Bacillus cereus G9842	neutral protease B	556	4e-33	0.29	0.48
EQYTVVDRKEDAWG-MKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN----------PVDQVVKIQSVDAIGEEGVKKIIA---SDNPETKDLVFL + + +V ++DA H+KL ++ + V + + LD+ V + G P + + + I + ++K I + + KDL KHFNIVGEEKDAESDTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLDDKNIPASASISAEQAETIAKADIEKEIGKVKNYDGVKKDLFVY AIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVA-------FNVPVEKSNTGIALHGTDNTGVYHAV D L Y V+ + S P Y V+AT+G ++EK + +HV + + SF++A FN+ K GI H D + + EKDGNY----YLAYLVKASISKPA-PGYWHYFVDATNGNVIEKYNAVDHVTGFGYGVLGARQSFEIAQDEKTGVFNLFDGKRGQGI--HTFDAENMDENL VDGKNNY-----SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVG + + + +++ S ++ AVDA+ + V YY+ F R+S DD+G ++S V ++++NA W+G M YG+ T ++ LDV+G FNLFSQWLGYTGEEVESKSKFFEDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISTV--HVGESWNNAAWNGVQMMYGDGDGKTFIPLSAGLDVIG HEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDR--ARYKGTPYYDQGGVHYNSG HE+TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D RY GT D GGVH NS HELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYSKRYTGTA--DNGGVHINSS IINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI I N+ Y + + +G E + I+Y +L YLT + F R A L +A+ YG ++ +V V+ A+++ G+ INNKAAYLVSEGGDHYDVKVAGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDAVGV
Show aligned area	118480127	Bacillus thuringiensis str. Al Hakam	neutral peptidase B	554	4e-33	0.28	0.48
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPV-----DQVVKIQSVDAIGEEGVKKI-IASDNPETKDLVFLAIDKRVN + + VV ++DA G H+KL ++ + V + + +D+ V + G + + + S+ A E + K I + + K+ + D V KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTIDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKEVGKVKNYDGVKKDLFVY NEGQLFYKVRVTSSPTGDPVS--LVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGV--YHAVVDGKNNYSI- + +Y + + P Y V+AT+G ++EK + +H+ + + SF++A + EK+ G GV + A +N ++I EKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYGVLGARQSFEIAQD---EKTGAFHLFDGKRGQGVHTFDAENMDENLFNIF ----------IQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMT +++ + ++ AVDA+ + V YY+ F R+S DD+G ++S V ++++NA W+G M YG+ T ++ LDV+GHE+T SQWFGHTGVEVESKNKFFDDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSV--HVGESWNNAAWNGVQMMYGDGDGTTFIPLSAGLDVIGHELT HGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDRARYKGTPYYDQGGVHYNSGIINRIG H VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D + T D GGVH NS I N+ HAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAA YTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y + + +G E + I+Y +L YLT + F R A L +A+ YG ++ +V V+ A+++ G+ YLVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDAVGV
Show aligned area	52140488	Bacillus cereus E33L	neutral protease B	554	5e-33	0.28	0.48
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN--PVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLV--FLAIDKRV--- + + VV ++DA G H+KL ++ + V + + LD+ V + G P + I +I E + I +D + V + + K + KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKEVGKVKNYDGVKKNLFVY NNEGQLFYKVRVTSSPTGD-PVSLVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVA-------FNVPVEKSNTGIALHGTDNTGVYHAVVDGKN +G + V +S + P Y V+AT+G ++EK + +H+ + + SF++A FN+ K GI H D + + + + EKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYGVLGARQSFEIAQDEKTGQFNLFDGKRGQGI--HTFDAENMDENLFNLFS NY-----SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTH + +++ S ++ AVDA+ + V YY+ F R+S DD+G ++S V ++++NA W+G M YG+ T ++ LDV+GHE+TH QWLGYTGEEVESKSKFFEDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSV--HVGESWNNAAWNGVQMMYGDGDGTTFIPLSAGLDVIGHELTH GVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDRARYKGTPYYDQGGVHYNSGIINRIGY VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D + T D GGVH NS I N+ Y AVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAY TI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI + + +G E + I+Y +L YLT + F R A L +A+ YG ++ +V V+ A+++ G+ LVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDAVGV
Show aligned area	30023075	Bacillus cereus ATCC 14579	bacillolysin	549	7e-33	0.28	0.48
EQYTVVDRKEDAWG-MKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN----------PVDQVVKIQSVDAIGEEGVKKIIA---SDNPETKDLVFL + + +V ++DA H+KL ++ + V + + LD+ V + G P + + + I + ++K I S + KDL KHFNIVGEEKDAESDTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLDDKNIPAAASITAEQAETIAKADIEKEIGKVKSYDGVKKDLFVY AIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVA-------FNVPVEKSNTGIALHGTDNTGV-YHA D L Y V+ + S P Y V+AT+G ++EK + +++ + + SF++A FN+ K G+ +N + EKDGNY----YLAYLVKASISKPA-PGYWHYFVDATNGNVIEKYNAVDNITGFGYGVLGARQSFEIAQDTKTGQFNLFDGKRGQGVHTFDAENMDENWFN VVDGKNNYS--IIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHE + Y+ +++ S ++ AVDA+ + V YY+ F R+S DD+G ++S V ++++NA W+G M YG+ T ++ LDV+GHE LFSQWLGYTGEEVESKSKFFEDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISTV--HVGESWNNAAWNGVQMMYGDGDGKTFIPLSAGLDVIGHE MTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDR--ARYKGTPYYDQGGVHYNSGII +TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + D+ +R+L+ P+ P ++ Y D RY GT D GGVH NS I LTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKS-WDLGADIYTPDKPGDALRSLKDPASIPNPLKPSEGYPDHYSKRYTGTA--DNGGVHINSSIN NRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI N+ Y + + +G E + I+Y +L YLT + F R A L +A+ YG + +V V+ A+++ G+ NKAAYLVSEGGDHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKNSKAVQAVTKAYDAVGV
Show aligned area	56421373	Geobacillus kaustophilus HTA426	hypothetical protein GK2838	287	1e-32	0.39	0.54
AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNES AVDA+ + V YY++ R S D I S V + Y+NAFW+G M YG+ T ++ +DVVGHE+TH VT++TAGL Y +SGA+NE+ AVDAHYYAGVVYDYYKNVHGRLSYDGSNAAIRSTV--HYGRGYNNAFWNGSQMVYGDGDGQTFLPFSGGIDVVGHELTHAVTDYTAGLVYQNESGAINEA YSDLMGYIIS--GASNP--EIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGI SD+ G ++ NP EIG D + +R++ P+K+G P+ ++ RY GT D GGVH NSGIIN+ Y + Q +G MSDIFGTLVEFYANRNPDWEIGEDIYTPGIAGDALRSMSDPAKYGDPDHYSK-----RYTGTQ--DNGGVHTNSGIINKAAYLLSQGGVHYGVSVTGIGR EKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI +K IFY +LV YLTP + FS R A + AA YG + V V AFN+ G+ DKMGKIFYRALVYYLTPTSNFSQLRAACVQAAADLYGSTSQEVNSVKQAFNAVGV
Show aligned area	42784229	Bacillus cereus ATCC 10987	neutral protease B, bacillolysin	591	2e-32	0.28	0.48
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN--PVDQVVKIQSVDAIGEEGVKKIIASDNPE----TKDLVFLAIDKRVN + + VV ++DA G H+KL ++ + V + + LD+ V + G P + I + I E + I +D + K+ + D V KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPAFAKISAEQAETIAKADIEKEVGKVKNYDGVKKDLYVY NEGQLFYKVRVTSSPTGDPVS--LVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVA-------FNVPVEKSNTGIALHGTDNT-----GVYHAV + +Y + + P Y V+AT+G ++EK + +++ + K SF++A FN+ K GI +N ++ + EKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDNITGFGYGVLGGKQSFEIAQDTKTGEFNLFDGKRGQGIHTFDAENMDENWFNLFSQI VDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTH + +++ S ++ AVDA+ + V YY+ F R+S DD+G ++S V ++++NA W+G M YG+ T ++ LDV+GHE+TH LGYTGEE--VKSKSKFFEDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISTV--HVGESWNNAAWNGVQMMYGDGDGKTFIPLSAGLDVIGHELTH GVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDR--ARYKGTPYYDQGGVHYNSGIINRI VTEHTA L Y + GALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D RY GT D GGVH NS I N+ AVTEHTANLVYKNEPGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTA--DNGGVHINSSINNKA GYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y + + +G E + I+Y +L YLT + F R A L +A+ YG + +V V+ A+++ G+ AYLVSEGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKNSKAVQAVTKAYDAVGV
Show aligned area	152977299	Bacillus cereus subsp. cytotoxis NVH 391-98	peptidase M4 thermolysin	478	2e-32	0.33	0.50
YKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKN---NYSII------------QAPSLVALNQNA Y ++AT+G ++EK + + + + K SF++A + EK+ G GV+ D KN N II ++ S ++ A YFIDATNGNVIEKYNAIDSITGFGYGVLGNKASFEIAQD---EKTGVYNLFDGKRGQGVH--TFDAKNMDENIFIILSQWFGYTGEEIESKSKFFEDKAA VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESY VDA+ + V YY+ F R+S D++G ++S V +A++NA W+G M YG+ T ++ LDV+GHE+TH VTE+TA L Y +SGALNES VDAHVNAGKVYDYYKKTFNRNSFDNKGAKLISAV--HVGEAWNNAAWNGVQMVYGDGDGKTFIPLSAGLDVIGHELTHAVTEYTANLVYQNESGALNESI SDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQ-YDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQ SD+MG ++ N +IGAD + D +R+L+ P+ P + Y D + YD GGVH NS I N+ Y + + +G E + SDIMGVMVE-KKNWDIGADIYTPDIEGDALRSLKDPASIPNPLKPGEGYPDHYSKRYVGPYDNGGVHINSSINNKAAYLVSEGGEHYGVKVTGIGREATE TIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI I+Y +L YLT A F R A L +A+ YG+ + +V V A+ S G+ KIYYHALTKYLTANADFKMMRQAALQSAEDLYGENSKAVQAVDKAYESVGV
Show aligned area	163942759	Bacillus weihenstephanensis KBAB4	peptidase M4 thermolysin	549	3e-32	0.27	0.47
EQYTVVDRKEDA-WGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN----------PVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAID + + +V ++DA G H+KL ++ + V + + LD+ V + G P + + + I + ++K I + K+ + D KHFNIVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPSLDDKNIPTSASISAEQAETIAKANIEKEIG----KVKNYDGVKKD KRVNNEGQLFYKVRVTSSPTGDPVS--LVYKVNATDGTIMEKQDLTEHVGS----EVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNN-- V + +Y + + P Y V+AT+G ++EK + +++ + + SF++A + N GT GV+ + N LYVYEKDGQYYLAYLVKASVSKPAPGYWHYFVDATNGNVIEKYNAVDNITGFGYGVLGARQSFEIAQDTKTGAFNL---FDGTRGQGVHTFDAENMNEDW YSI-----------IQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVG +++ I + S ++ AVDA+ + V YY+ F R+S DD+G ++S V ++++NA W+G M YG+ T ++ LDV+G FNLFSQILGYTGEEIGSKSKFFEDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISAV--HVGESWNNAAWNGVQMMYGDGDGKTFIPLSAGLDVIG HEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQ-YDDRARYKGTPYYDQGGVHYNSGII HE+TH VTEHTA L Y +SGALNES SD+MG ++ S ++GAD + + +R+L+ P+ P + Y D + T D GGVH NS I HELTHAVTEHTANLVYKDESGALNESLSDIMGVMVEKKS-WDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSIN NRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI N+ Y + + +G E + I+Y +L YLT + F R A L +A+ +G + V V+ A+++ G+ NKAAYLVSEGGTHYNVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLFGKNSKEVQAVTKAYDAVGV
Show aligned area	159900162	Herpetosiphon aurantiacus ATCC 23779	thermolysin	532	4e-32	0.29	0.46
HLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTG-----NPVDQVVKIQSVDAI--GEEGVKKIIASDNPETKDLVF-LAIDKRVNNEGQLFYKVRVTSSP +++L++ G+ V VI HLD G VT +G + +D + S +AI + VK + N ++ L I R + + ++V + NVRLDQTYAGLPVFGGQVIAHLDNKGNVTQESGELFAVDGIDTSASLSSAEAIKIAQSQVKYDFNAKNASGTEVSSELKILPREGKDSVIVFQVSLHIED TGDPVSL-VYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNN--YSIIQAPSLVALNQNA------VD + + + +NA G + + V + T K+ + ++ + + L G+Y ++ + + A ++ N A VD GSEATAHHEFFINAKTGETELYYNDMDGVNATGTGKSLYSGNVSITTDLVSGVYYLRDNSRGGMYTTNMNNRTTGGSTFTDADNVWGTNTTANVQSAGVD AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSD A+ + YY F R ID G +LS V + + Y+NAFW+G +M YG+ T + S LDV GHE+THG+TE TAGL Y +SGA NES+SD AHYGAQLTWDYYLSSFGRRGIDGNGFRVLSRV--HYGNRYNNAFWNGSSMTYGDGDGTTFRPLVS-LDVAGHEITHGLTEKTAGLIYSNESGAANESFSD LMGYII---SGASNPEIGADTQS-VDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ------------NLGIEK + G ++ SG + IG D + +RN+ P+ G P+ ++ RY GT D GGVH NSGI N++ Y + Q +G K IFGTMVEYSSGTGDYLIGEDIYTPATAGDALRNMSNPAAEGDPDHYSK-----RYTGTG--DNGGVHINSGIQNQVFYLLAQGGTNRTSGLAVTGIGRPK AQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAA--SVVSAAFNSAGI A IFY +L YLTP + F R A L AA+ YG +A + + A+ + G+ AAAIFYRALTVYLTPSSNFKAVRTATLNAARDLYGASSAEYNATAQAWTACGV
Show aligned area	153935262	Clostridium botulinum A str. Hall	thermolysin metallopeptidase	575	5e-32	0.29	0.43
MKGNKILYILGTGIFVGSSCLFSSLFVAAEEQVYSESEVSTVLSKLEK------EAISEAAAEQYTVVD---------------RKEDAWGMKHLKLEK- MK K+L IL + I SS SS++ A + S+ + T EK ++ + A+EQ+ + +K K LK EK MKSKKLLTILLSAIITASS--ISSVYAAESVGIKSKYQPKTTTIFWEKGKQNNKKSATNIASEQFNNFEEINQFFQQNISRFGLKKGSLKSTKALKDEKG --------QTEGVTVDSDNVIIHLDRNGAVTSVTGNPVD---------QVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVT Q EG+ V ++ +++ ++S+ G VD +K+ DAI + A +N + ++L D + N + Y V + KTHYHTIYQVEGIPVYYGRIVFTTEKDSTISSINGG-VDISFENENWKNKIKLSKSDAIAK-------AKNNIKYEELHDSKADLYLYNFEEKPYVVYLI --SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHG-------------------TDNTGVYHAVVDGKNNY-- S+ TGD V NA DG+I+ K + + + K + N V KSN I + G T G Y+ KN Y DLSTDTGDWNVFV---NAEDGSIVNKFNNIPTLTNTRDKKFTSTKKTNTKVNKSNNLIDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYVY ---------------SIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETST SI++A LV N N AVDAY + + YY++ F R+SID++GM + + + H + Y A W +M G+ DLNNKYINTFTTPKSSILKASKLVENNNNEFIDDKHIIAVDAYINLEKTYDYYKNKFNRNSIDNKGMNVEAFI--HHGEKYAGAEWSENLGSMLLGDGDG PTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPY + +LDVVGHE +HGVT + L+Y +SGALNES+SD+MG I G N ++G D + D IR++Q PSK QP M Y RNSSHMSKALDVVGHEFSHGVTRKESNLKYENESGALNESFSDIMGIAIKG-KNFKLGEDCWTPDIEGDAIRDMQDPSKGYQPAHMKDYRSM-----DIR YDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI----FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA YD GGVH NSGIIN Y I I+ LG+E ++ I FY++ FS R+ ++ K YG+ + +V AF+ GI A YDNGGVHVNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKDLYGENSKYVQIVENAFDKVGITA
Show aligned area	153931760	Clostridium botulinum A str. ATCC 19397	thermolysin metallopeptidase	575	5e-32	0.29	0.43
MKGNKILYILGTGIFVGSSCLFSSLFVAAEEQVYSESEVSTVLSKLEK------EAISEAAAEQYTVVD---------------RKEDAWGMKHLKLEK- MK K+L IL + I SS SS++ A + S+ + T EK ++ + A+EQ+ + +K K LK EK MKSKKLLTILLSAIITASS--ISSVYAAESVGIKSKYQPKTTTIFWEKGKQNNKKSATNIASEQFNNFEEINQFFQQNISRFGLKKGSLKSTKALKDEKG --------QTEGVTVDSDNVIIHLDRNGAVTSVTGNPVD---------QVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVT Q EG+ V ++ +++ ++S+ G VD +K+ DAI + A +N + ++L D + N + Y V + KTHYHTIYQVEGIPVYYGRIVFTTEKDSTISSINGG-VDISFENENWKNKIKLSKSDAIAK-------AKNNIKYEELHDSKADLYLYNFEEKPYVVYLI --SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHG-------------------TDNTGVYHAVVDGKNNY-- S+ TGD V NA DG+I+ K + + + K + N V KSN I + G T G Y+ KN Y DLSTDTGDWNVFV---NAEDGSIVNKFNNIPTLTNTRDKKFTSTKKTNTKVNKSNNLIDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYVY ---------------SIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETST SI++A LV N N AVDAY + + YY++ F R+SID++GM + + + H + Y A W +M G+ DLNNKYINTFTTPKSSILKASKLVENNNNEFIDDKHIIAVDAYINLEKTYDYYKNKFNRNSIDNKGMNVEAFI--HHGEKYAGAEWSENLGSMLLGDGDG PTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPY + +LDVVGHE +HGVT + L+Y +SGALNES+SD+MG I G N ++G D + D IR++Q PSK QP M Y RNSSHMSKALDVVGHEFSHGVTRKESNLKYENESGALNESFSDIMGIAIKG-KNFKLGEDCWTPDIEGDAIRDMQDPSKGYQPAHMKDYRSM-----DIR YDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI----FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA YD GGVH NSGIIN Y I I+ LG+E ++ I FY++ FS R+ ++ K YG+ + +V AF+ GI A YDNGGVHVNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKDLYGENSKYVQIVENAFDKVGITA
Show aligned area	148379414	Clostridium botulinum A str. ATCC 3502	secreted protease	575	5e-32	0.29	0.43
MKGNKILYILGTGIFVGSSCLFSSLFVAAEEQVYSESEVSTVLSKLEK------EAISEAAAEQYTVVD---------------RKEDAWGMKHLKLEK- MK K+L IL + I SS SS++ A + S+ + T EK ++ + A+EQ+ + +K K LK EK MKSKKLLTILLSAIITASS--ISSVYAAESVGIKSKYQPKTTTIFWEKGKQNNKKSATNIASEQFNNFEEINQFFQQNISRFGLKKGSLKSTKALKDEKG --------QTEGVTVDSDNVIIHLDRNGAVTSVTGNPVD---------QVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVT Q EG+ V ++ +++ ++S+ G VD +K+ DAI + A +N + ++L D + N + Y V + KTHYHTIYQVEGIPVYYGRIVFTTEKDSTISSINGG-VDISFENENWKNKIKLSKSDAIAK-------AKNNIKYEELHDSKADLYLYNFEEKPYVVYLI --SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHG-------------------TDNTGVYHAVVDGKNNY-- S+ TGD V NA DG+I+ K + + + K + N V KSN I + G T G Y+ KN Y DLSTDTGDWNVFV---NAEDGSIVNKFNNIPTLTNTRDKKFTSTKKTNTKVNKSNNLIDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYVY ---------------SIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETST SI++A LV N N AVDAY + + YY++ F R+SID++GM + + + H + Y A W +M G+ DLNNKYINTFTTPKSSILKASKLVENNNNEFIDDKHIIAVDAYINLEKTYDYYKNKFNRNSIDNKGMNVEAFI--HHGEKYAGAEWSENLGSMLLGDGDG PTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPY + +LDVVGHE +HGVT + L+Y +SGALNES+SD+MG I G N ++G D + D IR++Q PSK QP M Y RNSSHMSKALDVVGHEFSHGVTRKESNLKYENESGALNESFSDIMGIAIKG-KNFKLGEDCWTPDIEGDAIRDMQDPSKGYQPAHMKDYRSM-----DIR YDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI----FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA YD GGVH NSGIIN Y I I+ LG+E ++ I FY++ FS R+ ++ K YG+ + +V AF+ GI A YDNGGVHVNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKDLYGENSKYVQIVENAFDKVGITA
Show aligned area	110637614	Cytophaga hutchinsonii ATCC 33406	metalloprotease	1031	2e-31	0.36	0.51
ALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPD---AYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLG + N A+ A+ YY R SID G I+S ++ PD DNAFW+GKAM YG +T K A LDV GHE+THGV +++A L Y G SFNATAISAHYIAGKSYDYYSAIHGRTSIDGNGGTIISFINVADPDDGTPMDNAFWNGKAMYYGNGNT-NFKPLAGGLDVGGHELTHGVIQNSANLNYQG QSGALNESYSDLMGYIISGASNPEIGADTQSVDR--KTGIRNLQTPSKHG--------QPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQN +SGA+NES +D+ G +I + + +IG D + + +R+L P G QP +++ +Y GT D GGVH NSGI N Y + Q+ ESGAINESMADIFGCMID-SLDWKIGEDVVLLSKYPSGALRDLSNPHNGGTNINSRGWQPAHVSE-----KYSGTQ--DNGGVHINSGITNYAFYLLAQS LGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKEDIQVNQPSESVLVN KA+ IFY +L YLT ++F D R A +AAA Y A+ AF+ GI ++ S ++ VN TSRSKAEKIFYRALTAYLTRSSKFIDLRIACIAAATDLYTSNEATKTGIAFDQVGITGNSEVPTTPVSSNLPVN
Show aligned area	152974346	Bacillus cereus subsp. cytotoxis NVH 391-98	thermolysin	565	5e-31	0.27	0.45
LKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPV---DQVVKIQSVDAIGEEGVKKIIASD---NPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGD +++++ EG V + H+ ++G++ ++G V D+ K+++ + I E+ I D P+ + + N + + V + VRMQQVFEGTPVWGSTQVAHVSKDGSLKVLSGTVVPDLDKKEKLRNTNKIEEKKAIAIAEQDLGLKPKYEVEPKAHLHVYQNGDETTYAYVVNLNFLDPQ PVSLVYKVNATDGTIMEKQDLTEHVGSE-------------------VTLKNSFQVAFNVPVEKSNTGIALHGT-----DNT-GVYHAVVDGKNNYSI-- P + Y + A G ++ K + +HV E VT N+ V +K + L G+ DNT G D KN S+ PGNYYYFIEAESGKVLNKYNTLDHVTEESKVPVNQEFTKQEKGAIKPVTGTNAVGTGTGVLGDKKSINTTLSGSTYYLQDNTRGAQIFTYDAKNRSSLPG -----IQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTE + + AVDA+ + YY++ F R+SI+D G + S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE TLWADVDNAFHAKYDAAAVDAHYYAGVTYDYYKNTFNRNSINDAGAALKSTV--HYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTE HTAGLEYLGQSGALNESYSDLMGYIISGASNP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYT +++ L Y +SGALNE+ SD+ G ++ N EIG D + + +R++ P+K+G P+ ++ RY G+ D GGVH NSGIIN+ Y YSSNLIYQYESGALNEAISDIFGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSK-----RYTGSG--DNGGVHTNSGIINKAAYL I----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAK + + +G +K I+Y + Y T FS AR ++ AA YG +A V + + +G K LANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQAAADLYGANSAEVTAVKQSYDAVGVK
Show aligned area	153940215	Clostridium botulinum F str. Langeland	thermolysin metallopeptidase	572	8e-30	0.36	0.51
SIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETSTPTGKTYASSLDVVGH SI++A LV N N AVDAY + + YY++ F R+SID++GM + + + H + Y A W +M G+ + +LDVVGH SILKASKLVENNSNEFIDDKHIIAVDAYINLEKTYDYYKNKFNRNSIDNKGMNVEAFI--HHGEKYAGAEWSENLGSMLLGDGDGRNSSHMSKALDVVGH EMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINR E +HGVT + L+Y +SGALNES+SD+MG I G N ++G D + D IR++Q PSK QP M Y YD GGVH NSGIIN EFSHGVTRKESNLKYENESGALNESFSDIMGIAIKG-KNFKLGEDCWTPDIEGDAIRDMQDPSKGYQPAHMKDYRSM-----DIRYDNGGVHVNSGIINH IGYTI---IQNLGIEKAQTI----FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGI Y I I+ LG+E ++ I FY++ FS R+ ++ K YG+ + +V AF+ GI AAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKDLYGENSKYVQIVENAFDKVGI
Show aligned area	218901795	Bacillus cereus AH820	neutral protease Npr599	566	2e-29	0.35	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSKYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSDLIYQNESGALNEAISDVFGTLVEYYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY GT D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSK-----RYTGTS--DNGGVHTNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIG Y T FS AR ++ AA YG +A V + + + +G YFTQSTTFSQARAGLVQAAADLYGASSAEVAAVKQSYSAVG
Show aligned area	118476285	Bacillus thuringiensis str. Al Hakam	thermolysin	566	3e-29	0.35	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSRYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSDLIYQNESGALNEAISDVFGTLVEFYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY GT D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSK-----RYTGTG--DNGGVHTNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIG Y T FS AR ++ AA YG +A V + + + +G YFTQSTTFSQARAGLVQAATDLYGASSAEVAAVKQSYSAVG
Show aligned area	49183592	Bacillus anthracis str. Sterne	neutral protease	566	3e-29	0.35	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSRYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSDLIYQNESGALNEAISDVFGTLVEYYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY GT D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSK-----RYTGTG--DNGGVHTNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIG Y T FS AR ++ AA YG +A V + + + +G YFTQSTTFSQARAGLVQAAADLYGASSAEVAAVKQSYSAVG
Show aligned area	47525877	Bacillus anthracis str. 'Ames Ancestor'	neutral protease	566	3e-29	0.35	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSRYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSDLIYQNESGALNEAISDVFGTLVEYYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY GT D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSK-----RYTGTG--DNGGVHTNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIG Y T FS AR ++ AA YG +A V + + + +G YFTQSTTFSQARAGLVQAAADLYGASSAEVAAVKQSYSAVG
Show aligned area	30260755	Bacillus anthracis str. Ames	neutral protease	566	3e-29	0.35	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSRYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSDLIYQNESGALNEAISDVFGTLVEYYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY GT D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSK-----RYTGTG--DNGGVHTNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIG Y T FS AR ++ AA YG +A V + + + +G YFTQSTTFSQARAGLVQAAADLYGASSAEVAAVKQSYSAVG
Show aligned area	170760774	Clostridium botulinum A3 str. Loch Maree	thermolysin metallopeptidase	575	7e-29	0.29	0.45
EDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVD---------QVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNN-EGQLF +D G H Q +G+ V ++ +++ ++S+ G VD +K+ DAI + A +N + ++L D + N EG+ + KDEKGKTHYHTIYQVDGIPVYYGRIVFTTEKDSTISSINGG-VDISFENENWKNKIKLSKSDAIAK-------AKNNIKYEELHDSKADLYLYNFEGKPY YKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGI-------------ALHG------TDNTGVYHAVVDGK V S TGD V NA DG+I+ K + T + + K + N V KSN + +L+G T G Y+ K VVYLVDLSIDTGDWNIFV---NAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNKSNNVVDVQSNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNK NNY-----------------SIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFW--DGKAMRY N Y SI++A LV N + AVD Y + + YY++ F R+SID++GM + + + + + Y A W D +M NIYVYDLNNKYVNTFTTPRSSILKASKLVENNSSEFIDDKHIIAVDTYINLEKTYDYYKNKFNRNSIDNKGMNVEAFI--HYGENYAGAEWSEDLGSMLL GETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARY G+ + +LDVVGHE +HGVT + L+Y +SGALNES+SD+MG I G +N ++G D + + GIR++Q PSK QP M Y + GDGDGKDTSHMSKALDVVGHEFSHGVTHKESNLKYENESGALNESFSDIMGIAIKG-TNFKLGEDCWKPNTEEAGIRDMQDPSKKYQPAHMKDYRALRLH KGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI----FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA + D GGVH NSGIIN Y I I+ LG+E ++ I FY++ FS R+ ++ K YG+ + +V AF+ GI A E-----DNGGVHLNSGIINHAAYLIADGIEKLGLENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKNLYGENSKYVQIVENAFDKVGITA
Show aligned area	16078174	Bacillus subtilis subsp. subtilis str. 168	extracellular neutral protease B	538	1e-28	0.36	0.53
AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNES AVDA+ + + V YY F R S D G I S V ++NA W+G M YG+ K + SLD+V HE+TH VT+++AGL Y G+ GALNES AVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTV--HVGKQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALNES YSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQ SD+MG ++ + EIG D + +R+L+ PSK G P+ + RY GT D GGVH NS I N+ Y + ++ +G E ++ ISDIMG-AMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSN-----RYTGTE--DYGGVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASE TIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD--EAASVVSAAFNSAGI I+Y +L Y+T FS + A + AA YG+ + ++ V A+ + GI QIYYRALTYYVTASTDFSMMKQAAIEAANDLYGEGSKQSASVEKAYEAVGI
Show aligned area	29827907	Streptomyces avermitilis MA-4680	metalloprotease	950	1e-28	0.37	0.52
ALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV-DEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQS A AVDA+ V YY++ R S+D RGM I S+V + Y NAFWDG+ M YG + A+ LDVVGHEMTHGV +H+A L Y GQS ATEAGAVDAHWAAGQVYDYYKNKHGRDSLDGRGMSINSLVGTTDYGQPYVNAFWDGQKMVYGNGDAEY-RPLAAGLDVVGHEMTHGVVDHSADLVYAGQS GALNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPY-YDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFY GA+NE+ +D G I + AD S + +TP + + + G + D GGVH NS I + + I +++G A I Y GAMNEAIADYFGNAIETDVHGIAMADPDSGLLGEALCRTRTPRECAVRDLNDGRTTAKSFLGVGFGTDNGGVHLNSTIFSGALWDIREDVGPTLADKIVY SSLVNYLTPKAQFSDARDAMLAAAK-VQYGDEAASVVSAAFNSAGI +L YLTP F+ RDA++AAA+ + G + + V AFN+ GI KALTEYLTPLDGFTQGRDAVIAAARALGTGGKDLTAVQRAFNAHGI
Show aligned area	170760117	Clostridium botulinum A3 str. Loch Maree	bacillolysin	580	1e-28	0.33	0.51
VEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFW ++ SN I L+ +N+ + K+ I++ +LV N N AVD Y + YY++ F R+SID++GM + + ++NAFW LKDSNKNIYLYDLNNSWAPTIGIFSKD--YILRRSTLVENNSNKFTEDKHVTAVDGYVNLSKTYDYYKNKFNRNSIDNKGMNVEGFI--HTGKNFNNAFW --DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETM D +M +G+ ++AS+LDVVGHE++HG+T + L+Y +SGALNES+SD+MG I G N +IG D + + +R+++ PSK QP M RDDLGSMFFGDGDGVQFSSFASALDVVGHEVSHGITSKESKLKYEKESGALNESFSDIMGVAIEG-KNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHM AQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKA---------QTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFN + + K D GGVH NSGIIN Y I +G+EK+ +FY + +Y F+ R+ ++ AK YG + +V AF+ KDFKNLPNDKDN---DWGGVHTNSGIINHAAYLIA--VGMEKSGESNSKDIMANLFYRANCHYWDETTDFAKCRNDVVQVAKDLYGKNSKYVKIVENAFD SAGIGA GI A QVGITA
Show aligned area	217960177	Bacillus cereus AH187	metalloendopeptidase	567	2e-28	0.26	0.43
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKI A E V ++ L + ++ Y V+ +++ G +++++ EG V + H+D NG + SV+G+ S + +E +KK APENVVKDALKEKTEQALSSKQVNGETGVDYKVLQKRDSYDGTTLVRIQQTYEGKEVYGHQLTAHVDNNGVIKSVSGD---------SAQNLKQEELKKP IASDNPETKDLVFLAIDKRVN---------------NEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEK I E K ++ +N N GQ +VT + T VS Y VNA +G D+ +++ E LK S ++ + K INLSKDEAKQYIYTKYGNDINFISEPEVKEVIFVDENNGQASNAYQVTFEAATPKYVSGTYLVNAQNG------DMLKNMVQESNLKASDKLVSALKNSK SNTGIALHGT--DNTGV-------------------------------YHAVVDGKNNY--SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSID ++ +L GT D+ G+ Y + ++ Y ++ + S + AV A+ V +Y+D + R+S D KSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFD DRGMPILSVV------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGA ++G ++SVV D P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G+ NKGQKVVSVVHAWDSGDTNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGS SNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTP N +G T SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L FNWTMGEQTGSV-----FRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNM KAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI + F + R A + A +YG +A V V AF++A I TSNFKELRAACIRVATNKYGANSAEVQAVQKAFDAAKI
Show aligned area	23098121	Oceanobacillus iheyensis HTE831	metalloproteinase	528	3e-28	0.27	0.44
HLKLEKQTEGVTVDSDNVIIHLDRNGAVTS-------------VTGNPVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVR H ++++ +G+ + + I LD N VTS V GNP+ + I EE + + D D E + ++ HFRVKQTYKGIPIYGADQTISLDENNHVTSYFGQVVTGMNESIVVGNPITESEIIDIFKRNLEENIGTVDQFDGKIEADPYIYEY------EDEFYFTYL VTSSPTGDPVSLV-YKVNATDGTIME----KQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAV VT+S T V Y ++A G +++ QD+T + F+ + + T GV N ++ + + + AV VTASTTNPEVGFWHYFIDAKSGEVIDHFNASQDVTAFGTGVFGERQKFEAQ-----QYEDMFRLFDVTRGDGVVTYDNTTGTNVDVLSFNKMFS-DGAAV DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYS DA+ + + Y+ D F R+S+DD G ++S V D ++NA W+G+ M YG+ A LDV HEM+HGV +HTA L Y +SGALNES++ DAHANAQKTYDYFLDTFGRNSVDDNGQILISAV--HVGDNWNNASWNGRQMSYGDGDGIRFHPLAGGLDVAAHEMSHGVIQHTANLIYRNESGALNESFA DLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGY----------TIIQNLGIEKAQTIF D+ G ++ N +G D + D +R+L+ P+ + T Y D + D GGVH NS I N+ Y +++ +G + I+ DIFGAMVD-RENWLMGEDIMA-DGTLALRSLEDPAVLIERRTQEPYPDHWDRRYVGPLDNGGVHINSSINNKAAYLVAEGGEHYDVVVEGVGRAATEQIY YSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y +L YLT + FS R A + AA YG + V V A+N+ G+ YRALDLYLTSTSDFSMMRQAAIQAATDLYGSNSLHVEAVEQAYNAVGV
Show aligned area	153938981	Clostridium botulinum F str. Langeland	bacillolysin	579	3e-28	0.35	0.52
IIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHE I++ +LV N N AVD Y + YY++ F R+SID+ GM + + Y+NAFW D +M +G+ ++AS+LDVVGHE ILRHSTLVENNSNKFTSDEHVTAVDGYVNLSKTYDYYKNKFNRNSIDNNGMNVEGFI--HTGVKYNNAFWRDDLGSMFFGDGDGVRFSSFASALDVVGHE MTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRI ++HG+T + L+Y +SGALNES+SD+MG I G N +IG D + + +R+++ PSK QP M + + K D GGVH NSGIIN VSHGITSKESKLKYEKESGALNESFSDIMGVAIEG-KNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFKNLPNDKDN---DWGGVHTNSGIINHA GYTIIQNLGIEKA---------QTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA Y I +G+EK+ +FY + +Y F+ R+ ++ AK YG+ + +V AF+ GI A AYLIA--VGMEKSGESNGKDIMANLFYKANCHYWDETTDFAKCRNDVVQVAKDIYGENSKYVKIVENAFDQVGITA
Show aligned area	170754660	Clostridium botulinum B1 str. Okra	bacillolysin	579	3e-28	0.35	0.52
IIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHE I++ +LV N N AVD Y + YY++ F R+SID+ GM + + Y+NAFW D +M +G+ ++AS+LDVVGHE ILRHSTLVENNSNKFTSDEHVTAVDGYVNLSKTYDYYKNKFNRNSIDNNGMNVEGFI--HTGVKYNNAFWRDDLGSMFFGDGDGVRFSSFASALDVVGHE MTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRI ++HG+T + L+Y +SGALNES+SD+MG I G N +IG D + + +R+++ PSK QP M + + K D GGVH NSGIIN VSHGITSKESKLKYEKESGALNESFSDIMGVAIEG-KNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFKNLPNDKDN---DWGGVHTNSGIINHA GYTIIQNLGIEKA---------QTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA Y I +G+EK+ +FY + +Y F+ R+ ++ AK YG+ + +V AF+ GI A AYLIA--VGMEKSGESNGKDIMANLFYKANCHYWDETTDFAKCRNDVVQVAKDIYGENSKYVKIVENAFDQVGITA
Show aligned area	218897755	Bacillus cereus G9842	metalloendopeptidase	567	3e-28	0.26	0.45
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVK A E V ++ L ++ ++ A Y V+ ++ G +++++ EG V + H+D NG + SV+G+ + + ++ + ++ K APENVVKDALKEKTEQALSQKQVNGEAGVDYKVLQKRGSYDGTTLVRMQQTYEGKEVYGHQLTAHVDNNGVIKSVSGDSAQNLKQEELKKPINLSKDEAK KIIASD---------NPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTG + I + PE K+++F+ N GQ +VT + T + VS Y VNA +G D+ +++ E LK S ++ + K ++ QFIYTKYGNDIKFITEPEVKEVIFVD-----ENNGQAKNAYQVTFEAATPNYVSGTYLVNAQNG------DMLKNMVQESNLKASDKLVGALKKSKQSSL IALHGT--DNTGV-------------------------------YHAVVDGKNNYSIIQAPSLVAL--NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGM +L GT D+ G+ Y + ++ Y A S A + AV A+ V +Y+D ++R+S D++G TSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSATFNDPKAVSAHYLATKVFDFYKDKYKRNSFDNKGQ PILSVV------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPE ++SVV + P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G N KVVSVVHAWDSEETNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGNFNWT IGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQF +G T SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F MGEQTGSV-----FRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNF SDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI + + A + A +YG A V V AF++A I KELKSACIRVATNKYGANTAEVQAVQKAFDAAKI
Show aligned area	153933732	Clostridium botulinum A str. ATCC 19397	thermolysin metallopeptidase	597	4e-28	0.37	0.54
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM + V Y NAFW G+ +M +G+ + A +LDVVGHE++HGVT + L+Y +SGAL NSVDAYVNMGKSYDYYKNKLSRNSIDNKGMDVKGFV--HVGKDYGNAFWYGEYDSMFFGDGNGLYFSPLAKALDVVGHELSHGVTNKQSDLKYEKESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQ--- NES+SD+MG I G N EIG D + G +R+++ PS+ QP M + D + +D GGVH NSGIIN Y I + +G + ++ NESFSDIMGTAIEG-KNFEIGEDCWIPSDRYGEIMRDMKDPSRGNQPAHMKDFRDLPVDED---HDWGGVHTNSGIINHAAYLIADGFEKMGEKDSKDIM -TIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGA IFY + Y FS R+ ++ AK YGD + V V AF+ GI A AKIFYIANCYYWDQITDFSKCRNDVVKVAKDLYGDNSKEVQIVKNAFDQVGITA
Show aligned area	170754349	Clostridium botulinum B1 str. Okra	thermolysin metallopeptidase	597	4e-28	0.37	0.54
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM + V Y NAFW G+ +M +G+ + + A +LDVVGHE++HGVT + L+Y +SGAL NSVDAYVNMGKSYDYYKNKLSRNSIDNKGMDVKGFV--HVGKDYGNAFWYGEYDSMFFGDGNGLYFSSLAKALDVVGHELSHGVTNKQSDLKYEKESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQ--- NES+SD+MG I G N EIG D + G +R+++ PS+ QP M + D + +D GGVH NSGIIN Y I + +G + ++ NESFSDIMGTAIEG-KNFEIGEDCWIPSDRYGEIMRDMKDPSRGNQPAHMKDFRDLPVDED---HDWGGVHTNSGIINHAAYLIADGFEKMGEKDSKDIM -TIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGA IFY + Y F+ R+ ++ AK YGD + V V AF+ GI A AKIFYIANCYYWDQITDFAKCRNDVVKVAKDLYGDNSKEVQIVKNAFDQVGITA
Show aligned area	218234167	Bacillus cereus B4264	metalloendopeptidase	567	4e-28	0.26	0.44
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVK A E V ++ L ++ ++ A Y V+ ++ G +++++ EG V + H+D G + SV+G+ + + ++ + ++ K APENVVKDALKEKTEQALSQKQVNGEAGVDYKVLQKRGSYDGTTLVRMQQTYEGKEVYGHQLTAHVDNKGVIKSVSGDSAQNLKQEELKKTINLSKDEAK KIIAS---------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTG + I + PE K+++F+ N GQ +VT + T + VS Y VNA +G D+ +++ E LK S ++ + K ++ QYIYTKYGNNIKFISEPEVKEVIFVD-----ENNGQASNAYQVTFEAATPNYVSGTYLVNAQNG------DMLKNMVKESNLKASEKLVGALKKSKQSSL IALHGT--DNTGV-------------------------------YHAVVDGKNNYSIIQAPSLVAL--NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGM +L GT D+ G+ Y + ++ Y A S A + AV A+ V +Y+D ++R+S D++G TSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSATFNDPKAVSAHYLATKVFDFYKDKYKRNSFDNKGQ PILSVV------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPE ++SVV + P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G N KVVSVVHAWDSEETNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGNFNWT IGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQF +G T SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F MGEQTGSV-----FRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNF SDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI + R A + A +YG A V V AF++A I KELRSACIRVATNKYGANTAEVQAVQKAFDAAKI
Show aligned area	153936412	Clostridium botulinum A str. Hall	thermolysin metallopeptidase	594	4e-28	0.37	0.54
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM + V Y NAFW G+ +M +G+ + A +LDVVGHE++HGVT + L+Y +SGAL NSVDAYVNMGKSYDYYKNKLSRNSIDNKGMDVKGFV--HVGKDYGNAFWYGEYDSMFFGDGNGLYFSPLAKALDVVGHELSHGVTNKQSDLKYEKESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQ--- NES+SD+MG I G N EIG D + G +R+++ PS+ QP M + D + +D GGVH NSGIIN Y I + +G + ++ NESFSDIMGTAIEG-KNFEIGEDCWIPSDRYGEIMRDMKDPSRGNQPAHMKDFRDLPVDED---HDWGGVHTNSGIINHAAYLIADGFEKMGEKDSKDIM -TIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGA IFY + Y FS R+ ++ AK YGD + V V AF+ GI A AKIFYIANCYYWDQITDFSKCRNDVVKVAKDLYGDNSKEVQIVKNAFDQVGITA
Show aligned area	30020857	Bacillus cereus ATCC 14579	bacillolysin	567	6e-28	0.26	0.45
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVK A E V ++ L ++ ++ A Y V+ ++ G +++++ EG V + H+D G + SV+G+ + + ++ + ++ K APENVVKDALKEKTEQALSQKQVNGEAGVDYKVLQKRGSYDGTTLVRMQQTYEGKEVYGHQLTAHVDNKGVIKSVSGDSAQNLKQEELKKPINLSKDEAK KIIAS---------DNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGI + I + PE K+++F +D+ N + + Y+V+ ++ T + VS Y VNA +G D+ +++ E LK S ++ + K ++ QYIYTKYGNDIKFISEPEVKEVIF--VDEN-NGQAKNAYQVKFEAA-TPNYVSGTYLVNAQNG------DMLKNMVQESNLKASDKLVGALKKSKQSSLT ALHGT--DNTGV-------------------------------YHAVVDGKNNYSIIQAPSLVAL--NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMP +L GT D+ G+ Y + ++ Y A S A + AV A+ V +Y+D ++R+S D++G SLTGTGKDDLGINRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSATFNDPKAVSAHYLATKVFDFYKDKYKRNSFDNKGQK ILSVV------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEI ++SVV + P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G N + VVSVVHAWDSEETNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGNFNWTM GADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFS G T SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F GEQTGSV-----FRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFK DARDAMLAAAKVQYGDEAASV--VSAAFNSAGI + R A + A +YG A V V AF++A I ELRSACIRVATNKYGANTAEVQAVQKAFDAAKI
Show aligned area	153938607	Clostridium botulinum F str. Langeland	thermolysin metallopeptidase	597	7e-28	0.37	0.54
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM + V Y NAFW G+ +M +G+ + + A +LDVVGHE++HGVT + L+Y +SGAL NSVDAYVNMGKSYDYYKNKLSRNSIDNKGMDVKGFV--HVGKDYGNAFWYGEYDSMFFGDGNGLYFSSLAKALDVVGHELSHGVTNKQSDLKYEKESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQ--- NES+SD+MG I G N EIG D + G +R+++ PS+ QP M + D + +D GGVH NSGIIN Y I + +G + ++ NESFSDIMGTAIEG-KNFEIGEDCWIPSDRYGEIMRDMKDPSRGNQPAHMKDFRDLPVDED---HDWGGVHTNSGIINHAAYLIADGFEKMGEKDSKDIM -TIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGA IFY + Y F+ R+ ++ AK YGD + V V AF+ GI A AKIFYIANCYYWDQITDFAKCRNDVVKVAKDLYGDNSKEVQIVKNAFDQVGITA
Show aligned area	172035874	Cyanothece sp. ATCC 51142	putative peptidase M4, thermolysin	357	9e-28	0.36	0.52
NAVD-AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALN +AVD AY H +Y+ F R+SID+RGM ++S V Y+NAFW+G+ M YG+ + +LDV GHE+THGV H + LEY G+SGALN SAVDEAYDHAGITYDFYKQRFNRNSIDNRGMDLISSVHVGR--QYNNAFWNGRQMAYGDGDGQIFIRFTKALDVAGHEITHGVITHESNLEYQGESGALN ESYSDLMGYIIS----GASNP-----EIGADTQSVDRKTGIRNLQTPSKHGQPETMA--QYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--- ES++D+MG ++ G ++P ++G T +R + + + + R K T D GGVH NSGI N Y I ++G ESFADVMGALVQQWHLGQNDPNTADWDMGELIMGSSPATRLRTFKAEKAYEDDPYLGTDRQPKHIRDKYTGLEDNGGVHINSGIPNHAFYLIALDIGGPS IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD EKA I+Y +L N L ++ F +A D A +G+ WEKAGKIWYQTLRN-LNSQSDFQEAADMTYQVAGQLFGN
Show aligned area	52142776	Bacillus cereus E33L	extracellular neutral metalloprotease, bacillolysin	567	1e-27	0.26	0.45
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQ---SVDAIGEEGV A E V ++ L + ++ Y V+ +++ G +++++ EG V + H+D NG + SV+G+ + + + ++ +E APENVVKDALKEKTEQALSSKQVNGETGVDYKVLQKRDSYDGTTLVRIQQTYEGKEVYGHQLTAHVDNNGVIKSVSGDSAQNLKQEELKKPINLSKDEAQ KKIIAS--------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTL------------------ + I PE K+++F+ N GQ +VT + T + VS Y VNA +G +++ ++ + L QYIYTKYGNDINFISEPEVKEVIFVD-----ENNGQASNAYQVTFEAATPNYVSGTYLVNAQNGDMLKNMVQESNLKASEKLVGALKKSKKSSLTSLTGT -KNSFQVAFNVPVEK-SNTGIAL------HGTDNTGVYHAVVDGKNNY---SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV K+ ++ + + K SN AL G + V + + + +Y ++ + S + AV A+ V +Y+D + R+S D++G ++SVV GKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNKGQKVVSVV ------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQ D P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G+ N +G T HAWDSGDTNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTG SVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDA SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F + R A SV-----FRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSA MLAAAKVQYGDEAASV--VSAAFNSAGI + A +YG +A V V AF++A I CIRVATNKYGANSAEVQAVQKAFDAAKI
Show aligned area	163940370	Bacillus weihenstephanensis KBAB4	thermolysin	567	1e-27	0.26	0.45
YTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVKKIIAS---------DNPETKDLVFLAIDKR Y V+ ++ G +++++ EG V + H+D NG + SV+G+ + + ++ + ++ K+ I + PE K+++F+ YKVLQKRGSYDGTTLVRMQQTYEGKEVYGHQLTAHVDNNGVIKSVSGDSAQNLKQEELKKPINLSKDEAKQYIYTKYGNDIKFISEPEVKEVIFVD---- VNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGT--DNTGV----------------- N GQ +VT + T + VS Y VNA +G D+ +++ E LK S ++ + K ++ +L GT D+ G+ -ENNGQASNAYQVTFEAATPNYVSGTYLVNAQNG------DMLKNMVQESNLKASEKLVGALKESKKSSLTSLTGTGKDDLGISRSFGISKQSNGKYALA --------------YHAVVDGKNNY--SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV------DEQHPDAYDNAFW--DGK Y + ++ Y ++ + S + AV A+ V +Y+D ++R+S D++G ++SVV D P + NA +G DYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYKRNSFDNKGQKVVSVVHAWDSEDTNDPKNWQNALSANNGS AMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMA + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G+ N +G T SV R+++ P+ + MLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTGSV-----FRDMENPASVPSSLGVP QYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFN DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F + + A + A +YG A V V AF+ YPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELKSACIRVATNKYGANTAEVQAVQKAFD SAGI +A I AAKI
Show aligned area	148379416	Clostridium botulinum A str. ATCC 3502	secreted protease	594	2e-27	0.38	0.53
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA-YDNAFWDGK--AMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA N+VDAY + YY++ R+S+D++GM I V H D NAFW G+ +M +G+ A +LDVVGHE++HGVT + L+Y +SGA NSVDAYANMAKSYDYYKNKLSRNSLDNKGMNIKGFV---HFDKNLGNAFWVGEYDSMFFGDGDGVRLSPLAKALDVVGHELSHGVTNKQSDLKYEKESGA LNESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQ-- LNES+SD+MG I G N EIG D + G +R+++ PS+ QP M + D + +D GGVH NSGIIN Y I + +G + ++ LNESFSDIMGTAIEG-KNFEIGEDCWIPSDRYGEIMRDMKDPSRGNQPAHMKDFRDLPVDED---HDWGGVHTNSGIINHAAYLIADGFEKMGEKDSKDI --TIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGA IFY + Y FS R+ ++ AK YGD + V V AF+ GI A MAKIFYIANCYYWDQITDFSKCRNDVVKVAKDLYGDNSKEVQIVKNAFDQVGITA
Show aligned area	170761807	Clostridium botulinum A3 str. Loch Maree	thermolysin metallopeptidase	597	2e-27	0.37	0.52
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM + V Y NAFW G+ +M +G+ A +LDVVGHE++HGVT + L+Y +SGAL NSVDAYVNMGKSYDYYKNKLSRNSIDNKGMDVKGFV--HVGKNYGNAFWYGEYDSMFFGDGDGVRFSPLAKALDVVGHELSHGVTNKQSDLKYEKESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQY-----DDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEK NES+SD+MG I G N EIG D + G +R+++ PS+ QP M + DD+ D GGVH NSGIIN Y I + +G + NESFSDIMGTAIEG-KNFEIGEDCWIPSDRYGEIMRDMKDPSRGNQPAHMKDFRVLPVDDKN--------DWGGVHTNSGIINHAAYLIADGFEKMGEKD AQ----TIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGA ++ IFY + Y FS R+ ++ AK YGD + V V AF+ GI A SKDIMAKIFYIANCYYWDQITDFSKCRNDVVKVAKDLYGDNSKEVQIVKNAFDQVGITA
Show aligned area	170759277	Clostridium botulinum A3 str. Loch Maree	thermolysin metallopeptidase	581	3e-27	0.37	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM I V Y NAFW G M +G+ + A SLDVVGHE++HGVT + L+Y +SGAL NSVDAYVNTNKTYDYYKNKLNRNSIDNKGMNINGFVHVGR--NYGNAFWYGPYDGMFFGDGDGVYFSSLAKSLDVVGHELSHGVTNKESNLKYENESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQT------- NES+SD+MG + G N +G D +R+++ PS+ GQP M Y +YK T D GGVH NSGIIN Y + GIEK NESFSDIMGVAVEG-KNFVLGEDCWVAGGV--MRDMENPSRGGQPAHMKDY----KYK-TMNDDNGGVHTNSGIINHAAYLVAD--GIEKTGAKNSKDIM --IFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA IFY++ FS R+ ++ K YG+ + +V AF+ GI A GKIFYTANCYKWDETTNFSKCRNDVVQVTKELYGENSNYVKIVEKAFDQVGITA
Show aligned area	71736923	Pseudomonas syringae pv. phaseolicola 1448A	metalloprotease	356	4e-27	0.34	0.50
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPD------AYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA +AY V +Y + F+R+S+DD GM ++S V D NA+W+G M YG+ K + SL+V+GHE+THGV T+ L+Y GQSGA EAYDGSGDVYDFYAELFERNSLDDSGMSLVSTVHVAEVDFNGDHVPLSNAYWNGSQMAYGDGDDLVFKRFTGSLEVIGHELTHGVQSFTSNLDYRGQSGA LNESYSDLMGYIISGASNPEIGADTQSV---------DRKTGIRNLQTPSK----------HGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGY LNE ++D+ G ++ A++ V + GIR+++ P QP TMA Y GT D+GGVH NSGI NR LNEHFADVFGMLVRQWKQGTSAAESDWVVGKELLVPAPTRRGIRDMEKPGTAYSNDPDLGDDPQPATMADL-----YTGTK--DRGGVHINSGIPNRAFV TIIQNLG---IEKAQTIFYSSLVNYLTPKAQFSD-ARDAMLAAAKVQYGDEAASVVSAAFNSAGI + + LG E A I+Y +++ L +QF D AR ++ A+ ++G +A V AA+ G+ LVAKALGGNAWEVAGRIWYETMLE-LASDSQFVDCARASIKIASDSRFGPKAKKAVQAAWKEVGV
Show aligned area	170755979	Clostridium botulinum B1 str. Okra	thermolysin metallopeptidase	581	4e-27	0.37	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM I V Y NAFW G M +G+ + A SLDVVGHE++HGVT + L+Y +SGAL NSVDAYVNTNKTYDYYKNKLNRNSIDNKGMNINGFVHVGR--NYGNAFWYGPYDGMFFGDGDGVYFSSLAKSLDVVGHELSHGVTNKESNLKYENESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQT------- NES+SD+MG + G N +G D +R+++ PSK GQP M Y +YK T D GGVH NSGIIN Y + GIEK NESFSDIMGVAVEG-KNFVLGEDCWVAGGV--MRDMENPSKGGQPAHMKDY----KYK-TMDDDNGGVHTNSGIINHAAYLVAD--GIEKTGAKNSKDIM --IFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA IFY++ F+ R+ ++ K YG+ + +V AF+ GI A GKIFYTANCYKWDETTNFAKCRNDVVQVTKELYGENSNYVKIVEKAFDQVGITA
Show aligned area	172058943	Exiguobacterium sibiricum 255-15	thermolysin	511	5e-27	0.27	0.46
LKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGV----KKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGD ++L+++ +GV V V+ ++ ++G + +V + ++ K + ++ E+ +K I + E L I V ++ YKV T + VRLQQEVDGVPVFGSVVVGNVAKDGTLKAVVNDAINVKGKPGLAKKASLSEKKALKLYQKAIKATEFEVAPKAELVI-YPVKDDAVYAYKVTSTVLAGKE PVSLVYKVNATDGTIMEKQDLTEHV------------------GSEVTLKNSFQVAFNVPVEKSNTGIALHGTD----NTGVYHAVVDGKNNYSIIQAPS P Y ++A G ++ K D H N+ + ++ S G ++ D NT D N ++ + PSRWTYFIDANSGKVLNKYDQLAHAKPVNTVTGTTSVGTGTTVLGTTATFNTVKSGSYYYLQDSTRGKGIYTYDAKKRNTLPGSLWADLDNQFNTTYDRA LVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQ V+ NAV Y +Y++ + R+S D+ G + S V + +Y+NAFWDG M YG+ T + +LDVV HE+TH VTE+TAGL Y + AVSAQVNAVKTYD-------FYKNTYGRNSYDNAGAALNSSV--HYSTSYNNAFWDGTKMVYGDGDGSTFTYLSGALDVVAHELTHAVTEYTAGLVYQNE SGALNESYSDLMG----YIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI--------- SGA+NE+ SD+MG Y + + +G D + +R++ P+ +G P+ ++ RY GT D GGVH NSGI+N+ Y + SGAINEAVSDIMGTVAEYSVGSNFDWLVGEDIYTPGVSGDALRSMSNPAAYGDPDHYSK-----RYTGTQ--DNGGVHTNSGIVNKAAYLLGNGGTHTGV -IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYG + +G+ K I+Y +L YLTP + FS R A++ +AK YG TVTGVGVPKLGAIYYRALSVYLTPNSNFSSLRAAVVQSAKDLYG
Show aligned area	153939759	Clostridium botulinum F str. Langeland	thermolysin metallopeptidase	581	5e-27	0.37	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM I V Y NAFW G M +G+ + A SLDVVGHE++HGVT + L+Y +SGAL NSVDAYVNTNKTYDYYKNKLNRNSIDNKGMNINGFVHVGR--NYGNAFWYGPYDGMFFGDGDGVYFSSLAKSLDVVGHELSHGVTNKESNLKYENESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQT------- NES+SD+MG + G N +G D +R+++ PSK GQP M Y +YK T D GGVH NSGIIN Y + GIEK NESFSDIMGVAVEG-KNFVLGEDCWVAGGV--MRDMEDPSKGGQPAHMKDY----KYK-TMDDDNGGVHTNSGIINHAAYLVAD--GIEKTGAKNSKDIM --IFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA IFY++ F+ R+ ++ K YG+ + +V AF+ GI A GKIFYTANCYKWDETTNFAKCRNDVVQVTKELYGENSNYVKIVEKAFDQVGITA
Show aligned area	21240878	Xanthomonas axonopodis pv. citri str. 306	metalloprotease	356	6e-27	0.35	0.48
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYS +AY + +++ + R SID GMP++ V + YDNAFW+G+ M +G+ + ++DVVGHE+THGVTE TA L Y GQSGALNES S EAYDYLGATHDFFQTVYGRDSIDAAGMPLIGTV--HYERGYDNAFWNGEQMVFGDGDGEVFNRFTIAIDVVGHELTHGVTERTANLIYQGQSGALNESIS DLMGYIISGASNPEIGADTQSVD------------RKTGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ D+ G +I + +G D + G+R++Q P K QP TMA Y D D GGVHYNSGI N Y DVFGVLIKQYT---LGQSADQADWIIGAGLLMPGIQGVGLRSMQAPGSAYDDPALGKDPQPATMAGYVDTQE-------DDGGVHYNSGIPNHAFYRAAV NLG---IEKAQTIFYSSLV-NYLTPKAQFSDARDAMLAAAKVQYGDEAASVVS +G EK I+Y +L L A F+ D + A YG ++ V+ AIGGAAWEKTGRIWYRALTGGELAASADFATFADLTASVASADYGANSSEAVA
Show aligned area	222096239	Bacillus cereus Q1	extracellular neutral metalloprotease, bacillolysin	567	6e-27	0.26	0.43
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKI A E V ++ L + ++ Y V+ ++ G +++++ EG V + H+D NG + SV+G+ S + +E +KK APENVVKDALKEKTEQALSSKQVNGETGVDYKVLQKRGSYDGTTLVRIQQTYEGKEVYGHQLTAHVDHNGVIKSVSGD---------SAQNLKQEELKKP IASDNPETKDLVFLAIDKRVN---------------NEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTL-------------- I E K ++ +N N GQ +VT + T VS Y VNA +G +++ ++ + L INLSKDEAKQYIYTKYGNDINFISEPEVKEVIFVDENNGQASNAYQVTFEAATPKYVSGTYLVNAQNGDMLKNMVQESNLKASEKLVGALKKSKKSSLTS -----KNSFQVAFNVPVEK-SNTGIAL------HGTDNTGVYHAVVDGKNNY---SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPI K+ ++ + + K SN AL G + V + + + +Y ++ + S + AV A+ V +Y+D + R+S D++G + LTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNKGQKV LSVV------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIG +SVV + P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G+ N +G VSVVHAWDSEETNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMG ADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSD T SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F + EQTGSV-----FRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKE ARDAMLAAAKVQYGDEAASV--VSAAFNSAGI R A + A +YG +A V V AF++A I LRSACIRVATNKYGANSAEVQTVQKAFDAAKI
Show aligned area	42781632	Bacillus cereus ATCC 10987	neutral protease A, bacillolysin	891	7e-27	0.26	0.45
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVKKIIAS---------DNP L + +S Y V+ ++ G L++++ EG V + H+D+ G + SV+G+ + K +++ + +E K+ I + LSPKQVSGDKGVDYKVLQKRSSYDGTTLLRMQQIYEGKEVYGHQLTAHVDKKGVIKSVSGDSAQNLAKEDLKNPINLSKEEAKQYIYTKYGKDIQFISEA ETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGT--DNTGVYHAV E K+++F+ N GQ +VT ++ T + VS Y V+A G D+ +++ E +LK S + ++ K + IAL GT D+ G+ + EVKEVIFVD-----ENRGQATNAYQVTFAAATPNYVSGTYLVDAHSG------DMLKNMVQESSLKVSEEHLESLKESKKSNSIALTGTGKDDLGITRSF -VDGKNNYSIIQA-------------------------PSLVALNQN-------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQH------P + ++N + A P ++A + + AV A+ V +Y+D ++R+S D++G ++SVV H P GISEQSNGKYVLADYTRGQGIETYDVNYRDINFEEKYYPGILATSTSTTFNDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKKVVSVVHAWHSGETNDP DAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQSVDRKTGIRNLQT + NAF A + G + D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG YI +G N IG + V +RN++ KNWGNAF---SANINNVSMLIYGDPMVRAFDIAGHEFTHAVTSSESNLEFFGESGAINEALSDIMGTAIEKYINNGEFNWTIGEQSGLV-----LRNMKN PSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA PS + + DD +++ D GVH+NS IIN++ Y I Q +G +K IFY + + L + FS+ R A L A +YG + PSSVKFFDGVPYPDDYSKFSNLNGEDNEGVHFNSSIINKVAYLIAQGGTHNGVNVNGIGEDKMFDIFYYANTDELNMTSNFSELRLACLKVATNKYGANS ASV--VSAAFNSAGIGAKEDIQVNQPSESVLVNE V V AF++A I K ++ N+ +E+ V E IEVETVQKAFDAAKI--KGPVKENEKTEANQVPE
Show aligned area	153937247	Clostridium botulinum A str. Hall	thermolysin metallopeptidase	581	7e-27	0.37	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM I V Y NAFW G M +G+ + A SLDVVGHE++HGVT + L+Y +SGAL NSVDAYVNTNKTYDYYKNKLNRNSIDNKGMNINGFVHVGR--NYGNAFWYGPYDGMFFGDGDGIYFSSLAKSLDVVGHELSHGVTNKESNLKYENESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQT------- NES+SD+MG + G N +G D +R+++ PS+ GQP M Y +YK T D GGVH NSGIIN Y + GIEK NESFSDIMGVAVEG-KNFVLGEDCWVAGGV--MRDMENPSRGGQPAHMKDY----KYK-TMNDDNGGVHTNSGIINHAAYLVAD--GIEKTGAKNSKDIM --IFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA IFY++ F+ R+ ++ K YG+ + +V AF+ GI A GKIFYTANCYKWDETTNFAKCRNDVVQVTKELYGENSNYVKIVEKAFDQVGITA
Show aligned area	153932249	Clostridium botulinum A str. ATCC 19397	thermolysin metallopeptidase	581	7e-27	0.37	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM I V Y NAFW G M +G+ + A SLDVVGHE++HGVT + L+Y +SGAL NSVDAYVNTNKTYDYYKNKLNRNSIDNKGMNINGFVHVGR--NYGNAFWYGPYDGMFFGDGDGIYFSSLAKSLDVVGHELSHGVTNKESNLKYENESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQT------- NES+SD+MG + G N +G D +R+++ PS+ GQP M Y +YK T D GGVH NSGIIN Y + GIEK NESFSDIMGVAVEG-KNFVLGEDCWVAGGV--MRDMENPSRGGQPAHMKDY----KYK-TMNDDNGGVHTNSGIINHAAYLVAD--GIEKTGAKNSKDIM --IFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA IFY++ F+ R+ ++ K YG+ + +V AF+ GI A GKIFYTANCYKWDETTNFAKCRNDVVQVTKELYGENSNYVKIVEKAFDQVGITA
Show aligned area	148379417	Clostridium botulinum A str. ATCC 3502	secreted protease	581	7e-27	0.37	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+VDAY + YY++ R+SID++GM I V Y NAFW G M +G+ + A SLDVVGHE++HGVT + L+Y +SGAL NSVDAYVNTNKTYDYYKNKLNRNSIDNKGMNINGFVHVGR--NYGNAFWYGPYDGMFFGDGDGIYFSSLAKSLDVVGHELSHGVTNKESNLKYENESGAL NESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQT------- NES+SD+MG + G N +G D +R+++ PS+ GQP M Y +YK T D GGVH NSGIIN Y + GIEK NESFSDIMGVAVEG-KNFVLGEDCWVAGGV--MRDMENPSRGGQPAHMKDY----KYK-TMNDDNGGVHTNSGIINHAAYLVAD--GIEKTGAKNSKDIM --IFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA IFY++ F+ R+ ++ K YG+ + +V AF+ GI A GKIFYTANCYKWDETTNFAKCRNDVVQVTKELYGENSNYVKIVEKAFDQVGITA
Show aligned area	118477963	Bacillus thuringiensis str. Al Hakam	bacillolysin	890	7e-27	0.28	0.45
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVKKIIAS---------DNP L + +S Y V+ ++ G ++L++ EG V + H+D+ G + SV+G + K +++ + +E K+ I P LSPKQVSGDKGVDYKVLQKRGSYDGTTLVRLQQIYEGKEVYGHQLTAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYKKYGNDIKFISEP ETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGT--DNTGVY--- E K+++F+ N GQ +VT ++ T + VS Y V+A +G +M K L E LK S + ++ K + I+L GT D+ G+ EVKEVIFVD-----ENNGQASNAYQVTFAAATPNYVSGTYLVDAHNG-VMLKNTLQES-----DLKVSEEQVESLKENKKSNSISLTGTGKDDLGITRIF ---------HAVVDGKN---------NYSIIQ-----APSLVALNQN-------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNA +A+ D NY I P ++A + + AV A+ V +Y+D ++R+S D++G I+SVV H D+ GISEQSNGKYALADYTRGQGIETYDVNYRDINFEERYYPGILATSTSTTFDDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKKIVSVVHAWHSGETDDP FWDGKAMRYGETSTPT---GKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQSVDRKTGIRNLQTPSK G A + G + D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG YI +G N IG + SV +R+++ PS KNWGNAFSANINNVSMLIYGDPMVRAFDIAGHEFTHAVTSSESNLEFFGESGAINEALSDIMGTAIEKYINNGKFNWTIGEQSGSV-----LRDMKNPSS HGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV + + DD ++Y D GVH+NS IIN++ Y I Q +G +K IFY + + L + FS+ R A L A +YG + V VKFFDGVPYPDDYSKYSDLNGEDNEGVHFNSSIINKVAYLIAQGGTHNGVTVNGIGEDKMFDIFYYANTDELNMTSNFSELRLACLKVATNKYGANSIEV --VSAAFNSAGIGA--KED--IQVNQPSE V AF++A I KED +VNQ E ETVQKAFDAAKIKGPVKEDEKTEVNQVPE
Show aligned area	218897520	Bacillus cereus G9842	bacillolysin	893	8e-27	0.26	0.45
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVK A E V ++ L + +S Y V+ ++ G +++++ EG V + H+D+ G + S++G+ + + ++ + +E K APENVVKDALKENTEHALSPKQVSAETGVDYKVLQKRGSYDGTTLVRMQQIYEGKEVYGHQLTAHVDKKGIIKSISGDSAQNLTQEDLKKPINLSKEEAK KIIAS---------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTG + I PE K ++F+ N GQ +VT ++ T + VS Y VNA +G ++ +D+ + E +LK S + +V K++ QYIYKKYGNDTKFISEPEVKAVIFVD-----ENHGQASNAYQVTFAATTPNYVSGTYLVNAHNGEML--KDMVQ----ESSLKISEEYVQSVKENKTSNF IALHGT--DNTGV-------------------------------YHAVVDGKNNYSIIQAPSLVAL--NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGM +L GT D+ GV Y + + ++ Y I A S+ + AV A+ V +Y++ ++R+S D++G TSLTGTGKDDLGVTRTFGISKQTSGNYALADYTRGQGIETYDVNYRDITNEESYYPGILATSVSTTFNDPKAVSAHFLATKVYDFYKEKYKRNSFDNKGN PILSVVDE------QHPDAYDNAFWDG----KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASN ++SVV P+ ++NAF + YG+ P K + D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG YI +G N KVVSVVHAWDSGGTNDPENWENAFSTNINNISMLLYGD---PMVKAF----DIAGHEFTHAVTSSESNLEFSGESGAINEALSDIMGTAIEKYINNGEFN PEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKA IG T S+ RN++ P+ + + DD ++Y D GGVH+NS IIN++ Y I Q +G +K IFY + + L + WTIGEQTGSI-----FRNMKNPTAINFSDGLPYPDDYSKYNDLNGEDYGGVHFNSSIINKVAYLIAQGGTHNGVNVNGIGEDKMFDIFYYANTDELNMTS QFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI FS+ + A L A +YG + V V AF++A I NFSELKLACLKVATNKYGTNSIEVQAVQNAFDAAKI
Show aligned area	49479164	Bacillus thuringiensis serovar konkukian str. 97-27	extracellular neutral metalloprotease, bacillolysin	567	9e-27	0.25	0.45
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQ---SVDAIGEEGV A E V ++ L + ++ Y V+ ++ G +++++ EG V + H+D +G + SV+G+ + + + +++ +E APENVVKDALKEKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQTYEGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKTINLSKDEAT KKIIAS--------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTL------------------ + I PE K+++F+ N GQ +VT + T + VS Y +NA +G +++ ++ + L QYIYTKYGNDINFISEPEVKEVIFVD-----ENNGQASNAYQVTFEAATPNYVSGTYLINAQNGDMLKNMVQESNLKASEKLVGALKKSKKSSLTSLTGT -KNSFQVAFNVPVEK-SNTGIAL------HGTDNTGVYHAVVDGKNNY---SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV K+ ++ + + K SN AL G + V + + + +Y ++ + S + AV A+ V +Y+D + R+S D++G ++SVV GKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKVVSVV ------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQ D P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G+ N +G T HAWDSGDTNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTG SVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDA SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F + R A SV-----FRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSA MLAAAKVQYGDEAASV--VSAAFNSAGI + A +YG +A V V AF++A I CIRVATNKYGANSAEVQAVQKAFDAAKI
Show aligned area	49477766	Bacillus thuringiensis serovar konkukian str. 97-27	bacillolysin (neutral protease)	890	1e-26	0.27	0.45
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVKKIIAS---------DNP L + +S Y V+ ++ G L+L++ EG V + H+D+ G + SV+G+ + K +++ + E K+ I + P LSPKQVSGDKGVDYKVLQKRGSYDGTTLLRLQQIYEGKEVYGHQLTAHVDKKGVIKSVSGDSAQNLAKEDLKNPINLSNEEAKQYIYTKYGNDIKFISEP ETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGT--DNTGVY--- E K+++F+ N GQ +VT ++ T + VS Y V+A G D+ +++ E +LK S + ++ K + I+L GT D+ G+ EVKEVIFVD-----ENRGQPTNAYQVTFAAATPNYVSGTYLVDAHSG------DMLKNMVQESSLKVSEEHLESLKESKKSNSISLTGTGKDDLGITRSF ---------HAVVDGKN---------NYSIIQ-----APSLVALNQN-------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNA +A+ D NY I P ++A + + AV A+ V +Y+D ++R+S D++G ++SVV H D+ GISEQSNGKYALADYTRGQGIETYDVNYRDINFEEKYYPGILATSTSTTFNDPRAVSAHFLATKVYDFYKDKYKRNSFDNKGKKVVSVVHAWHSGETDDP FWDGKAMRYGETSTPT---GKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQSVDRKTGIRNLQTPSK G A + G + D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG Y+ +G N IG + SV +RN++ PS KNWGNAFSANINNVSMLIYGDPMVRAFDIAGHEFTHAVTSSESNLEFFGESGAINEALSDIMGTAIEKYVNNGEFNWTIGEQSGSV-----LRNMKNPSS HGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV + DD +++ D GVH+NS IIN++ Y I Q +G +K IFY + + L + FS+ R A L A +YG + V VKFFNGVPYPDDYSKFSDLNGEDNEGVHFNSSIINKVAYLIAQGGTHNGVTVNGIGEDKMFDIFYYANTDELNMTSNFSELRLACLKVATNRYGVNSIEV --VSAAFNSAGI V AF++A I EAVQKAFDAAKI
Show aligned area	148273069	Clavibacter michiganensis subsp. michiganensis NCPPB 382	zinc metalloprotease family M4	348	1e-26	0.33	0.48
ALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVD--------AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGE AL G D +G++ + D N + P + A D AY + + + + R S+DDRG+P+L+ V + + YDNAFWDG M +G+ ALAGRDPSGIHRTISDAGNREEL---PGRTVRVEGAPDTGDAQVDEAYAGLGATYSLFSEVYGRESLDDRGLPLLATV--HYGEEYDNAFWDGTRMVFGD TSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPE--------IGADTQSVDRKTG--IRNLQTP---------SK + SL V+GHE+THGVTE T GL Y GQSGALNES SD+ G ++ S + +GA+ ++R TG +R++ P K GDGEVFAPFTRSLTVIGHELTHGVTELTLGLVYQGQSGALNESISDVFGVLVEQHSLGQKADEATWLVGAEL-FLERSTGQALRSMSAPGTAYDDDVLGK HGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINR---IGYTIIQNLGIEKAQTIFYSSLVN-YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAA QP M Y + D GG+H NSGI NR + T I E A ++Y + + + A F A + AA +YG+ A+ V V AA DPQPGHMDDYVETQE-------DNGGIHINSGIPNRAFFLAATAIGGAAWEGAGRVWYDVIESGAVRADADFPAFSRATIDAAAARYGEGASEVAAVQAA FNSAGI + GI WEGVGI
Show aligned area	49480192	Bacillus thuringiensis serovar konkukian str. 97-27	bacillolysin (thermolysin-like metalloprotease, peptidase M4)	566	1e-26	0.36	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSRYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSDLIYQNESGALNEAISDVFGTLVEFYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY GT D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSK-----RYTGTS--DNGGVHTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y T FS AR + AA YG +A V V +F++ GI YFTQSTTFSQARAGAVQAAADLYGANSAEVNAVKQSFSAVGI
Show aligned area	52144711	Bacillus cereus E33L	bacillolysin (thermolysin-like metalloprotease, peptidase M4)	566	1e-26	0.36	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSRYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSDLIYQNESGALNEAISDVFGTLVEFYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY GT D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSK-----RYTGTS--DNGGVHTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y T FS AR + AA YG +A V V +F++ GI YFTQSTTFSQARAGAVQAAADLYGANSAEVNAVKQSFSAVGI
Show aligned area	170781738	Clavibacter michiganensis subsp. sepedonicus	putative metalloprotease	348	1e-26	0.34	0.49
ALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFV---KTY--YEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETST AL D +G++ V D N + V + + DA + TY + + + R S+DDRG+P+L+ V + + YDNAFWDG M +G+ ALADRDPSGIHRTVSDAGNREELPGRTVRVEGDADTGDAEVDEAYAGLGATYALFSEVYGRESLDDRGLPLLATV--HYGEEYDNAFWDGTRMVFGDGDG PTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS----GASNPE----IGADTQSVDRKTG--IRNLQTP---------SKHGQ + SL V+GHE+THGVTE T GL Y GQSGALNES SD+ G ++ G + E +GA+ ++R TG +R+++ P K Q EVFAPFTRSLTVIGHELTHGVTELTLGLVYQGQSGALNESVSDVFGVLVEQHALGQTADEATWLVGAEL-FLERSTGLALRSMRAPGTAYDDDVLGKDPQ PETMAQYDDRARYKGTPYYDQGGVHYNSGIINR---IGYTIIQNLGIEKAQTIFYSSLVN-YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNS P M Y + D GGVH NSGI NR + T I E A ++Y + + + F+ A + AA +YG++A+ V V AA+ PGHMDDYVETQE-------DNGGVHINSGIPNRAFFLAATAIGGAAWEGAGRVWYDVIESGAVRADPDFAAFAGATVEAASARYGEDASEVAAVQAAWEG AGI GI VGI
Show aligned area	218903697	Bacillus cereus AH820	neutral protease	884	1e-26	0.28	0.45
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVKKIIAS---------DNP L + +S Y V+ ++ G ++L++ EG V + H+D+ G + SV+G + K +++ + +E K+ I P LSPKQVSGDKGVDYKVLQKRGSYDGTTLVRLQQIYEGKEVYGHQLTAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYKKYGNDIKFISEP ETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGT--DNTGVY--- E K+++F+ N GQ +VT ++ T + VS Y ++A +G +M K L E LK S + ++ K + I+L GT D+ G+ EVKEVIFVD-----ENNGQASNAYQVTFAAATPNYVSGTYLMDAHNG-VMLKNTLQES-----DLKVSEEQVESLKENKKSNSISLTGTGKDDLGITRIF ---------HAVVDGKN---------NYSIIQ-----APSLVALNQN-------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNA +A+ D NY I P ++A + + AV A+ V +Y+D ++R+S D++G I+SVV H D+ GISEQSNGKYALADYTRGQGIETYDVNYRDINFEERYYPGILATSTSTTFDDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKKIVSVVHAWHSGETDDP FWDGKAMRYGETSTPT---GKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQSVDRKTGIRNLQTPSK G A + G + D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG YI +G N IG + SV +R+++ PS KNWGNAFSANINNVSMLIYGDPMVRAFDIAGHEFTHAVTSSESNLEFFGESGAINEALSDIMGTAIEKYINNGKFNWTIGEQSGSV-----LRDMKNPSS HGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV + + DD ++Y D GVH+NS IIN++ Y I Q +G +K IFY + + L + FS+ R A L A +YG + V VKFFDGVPYPDDYSKYSDLNGEDNEGVHFNSSIINKVAYLIAQGGTHNGVTVNGIGEDKMFDIFYYANTDELNMTSNFSELRLACLKVATNKYGANSIEV --VSAAFNSAGIGA--KED--IQVNQPSE V AF++A I KED +VNQ E ETVQKAFDAAKIKGPVKEDEKTEVNQVPE
Show aligned area	153940979	Clostridium botulinum F str. Langeland	thermolysin metallopeptidase	594	1e-26	0.36	0.53
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA-YDNAFWDGK--AMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA N+VDAY + YY++ R+S+D++GM I V H D NAFW G+ +M +G+ A +LD+VGHE++HGVT + L+Y +SGA NSVDAYANMAKSYDYYKNKLSRNSLDNKGMNIKGFV---HFDKNLGNAFWVGEYDSMFFGDGDGVRLSPLAKALDIVGHELSHGVTNKASNLKYEKESGA LNESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI LNES+SD+MG I G N EIG D G +R+++ PS+ QP M + + D GGVH NSGIIN Y I + +G + ++ I LNESFSDIMGTAIEG-KNFEIGEDCWIPTWFYGEVMRDMKDPSRGRQPAHMKNFRKLPVDRDN---DWGGVHINSGIINHAAYLIADGFEKMGAKDSKDI ----FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA FY + Y F+ R+ ++ AK YGD + A +V AF+ GI A MGKLFYIANCYYWDETTDFAKCRNDVVKVAKDLYGDNSKEAEIVKNAFDQVGITA
Show aligned area	30018788	Bacillus cereus ATCC 14579	bacillolysin	566	2e-26	0.36	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSKYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTENSSDLIYQNESGALNEAISDIFGTLVEFYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY GT D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPAKYGDPDHYSK-----RYTGTS--DNGGVHTNSGIINKQAYLLANGGTHSGVTVTGIGKDKLGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y T FS AR + AA YG +A V V +F++ GI YFTQSTTFSQARAGAVQAAADLYGATSAEVAAVKQSFSAVGI
Show aligned area	153934792	Clostridium botulinum A str. Hall	thermolysin metallopeptidase	580	2e-26	0.32	0.50
VEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFW ++ SN I L+ +N+ + K+ I++ +LV N N AVD Y + YY++ F R+SID++GM + + ++NAFW LKDSNKNIYLYNLNNSWAPTIGIFSKD--YILRRSTLVENNSNKFTEDKHVTAVDGYVNLSKTYDYYKNKFNRNSIDNKGMNVEGFI--HTGKNFNNAFW --DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETM D +M +G+ ++AS+LDVVGHE++HG+T + L+Y +SGALNES+SD+MG I G N +IG D + + +R+++ PSK QP M RDDLGSMFFGDGDGVKFSSFASALDVVGHEVSHGITSKESKLKYEKESGALNESFSDIMGVAIEG-KNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHM AQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKA---------QTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFN + K +D GGVH NSGIIN Y I G+EK+ +FY + F+ R+ ++ K YG+ + +V AF+ KDFQYLPNDKD---HDWGGVHTNSGIINHAAYLIAD--GMEKSGEKNSKDIMAKLFYRANCYKWDETTNFAKCRNDVVQVTKDLYGENSKYVKIVENAFD SAGIGA GI A QVGITA
Show aligned area	153931929	Clostridium botulinum A str. ATCC 19397	thermolysin metallopeptidase	580	2e-26	0.32	0.50
VEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFW ++ SN I L+ +N+ + K+ I++ +LV N N AVD Y + YY++ F R+SID++GM + + ++NAFW LKDSNKNIYLYNLNNSWAPTIGIFSKD--YILRRSTLVENNSNKFTEDKHVTAVDGYVNLSKTYDYYKNKFNRNSIDNKGMNVEGFI--HTGKNFNNAFW --DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETM D +M +G+ ++AS+LDVVGHE++HG+T + L+Y +SGALNES+SD+MG I G N +IG D + + +R+++ PSK QP M RDDLGSMFFGDGDGVKFSSFASALDVVGHEVSHGITSKESKLKYEKESGALNESFSDIMGVAIEG-KNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHM AQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKA---------QTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFN + K +D GGVH NSGIIN Y I G+EK+ +FY + F+ R+ ++ K YG+ + +V AF+ KDFQYLPNDKD---HDWGGVHTNSGIINHAAYLIAD--GMEKSGEKNSKDIMAKLFYRANCYKWDETTNFAKCRNDVVQVTKDLYGENSKYVKIVENAFD SAGIGA GI A QVGITA
Show aligned area	148379418	Clostridium botulinum A str. ATCC 3502	secreted protease	580	2e-26	0.32	0.50
VEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQN---------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFW ++ SN I L+ +N+ + K+ I++ +LV N N AVD Y + YY++ F R+SID++GM + + ++NAFW LKDSNKNIYLYNLNNSWAPTIGIFSKD--YILRRSTLVENNSNKFTEDKHVTAVDGYVNLSKTYDYYKNKFNRNSIDNKGMNVEGFI--HTGKNFNNAFW --DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVD-RKTGIRNLQTPSKHGQPETM D +M +G+ ++AS+LDVVGHE++HG+T + L+Y +SGALNES+SD+MG I G N +IG D + + +R+++ PSK QP M RDDLGSMFFGDGDGVKFSSFASALDVVGHEVSHGITSKESKLKYEKESGALNESFSDIMGVAIEG-KNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHM AQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKA---------QTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFN + K +D GGVH NSGIIN Y I G+EK+ +FY + F+ R+ ++ K YG+ + +V AF+ KDFQYLPNDKD---HDWGGVHTNSGIINHAAYLIAD--GMEKSGEKNSKDIMAKLFYRANCYKWDETTNFAKCRNDVVQVTKDLYGENSKYVKIVENAFD SAGIGA GI A QVGITA
Show aligned area	49185551	Bacillus anthracis str. Sterne	neutral protease	567	2e-26	0.25	0.44
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQ---SVDAIGEEGV A E V ++ L + ++ Y V+ ++ G +++++ EG V + H+D +G + SV+G+ + + + ++ +E APENVVKDALKEKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQTYEGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKPINLSKDEAT KKIIAS--------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTL------------------ + I PE K+++F+ N GQ +VT + T + +S Y +NA +G +++ ++ + L QYIYTKYGNDINFISEPEVKEVIFVD-----ENNGQASNAYQVTFEAATPNYISGTYLINAQNGDMLKNMVQESNLKASEKLVGALKKSKKSSLTSLTGT -KNSFQVAFNVPVEK-SNTGIAL------HGTDNTGVYHAVVDGKNNY---SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV K+ ++ + + K SN AL G + V + + + +Y ++ + S + AV A+ V +Y+D + R+S D++G ++SVV GKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKVVSVV ------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQ D P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G+ N +G T HAWDSGDTNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTG SVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDA SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F + R A SV-----FRDMENPTSVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSA MLAAAKVQYGDEAASV--VSAAFNSAGI + A +YG +A V V AF++A I CIRVATNKYGANSAEVQAVQKAFDAAKI
Show aligned area	47528021	Bacillus anthracis str. 'Ames Ancestor'	neutral protease	567	2e-26	0.25	0.44
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQ---SVDAIGEEGV A E V ++ L + ++ Y V+ ++ G +++++ EG V + H+D +G + SV+G+ + + + ++ +E APENVVKDALKEKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQTYEGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKPINLSKDEAT KKIIAS--------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTL------------------ + I PE K+++F+ N GQ +VT + T + +S Y +NA +G +++ ++ + L QYIYTKYGNDINFISEPEVKEVIFVD-----ENNGQASNAYQVTFEAATPNYISGTYLINAQNGDMLKNMVQESNLKASEKLVGALKKSKKSSLTSLTGT -KNSFQVAFNVPVEK-SNTGIAL------HGTDNTGVYHAVVDGKNNY---SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV K+ ++ + + K SN AL G + V + + + +Y ++ + S + AV A+ V +Y+D + R+S D++G ++SVV GKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKVVSVV ------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQ D P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G+ N +G T HAWDSGDTNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTG SVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDA SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F + R A SV-----FRDMENPTSVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSA MLAAAKVQYGDEAASV--VSAAFNSAGI + A +YG +A V V AF++A I CIRVATNKYGANSAEVQAVQKAFDAAKI
Show aligned area	30262703	Bacillus anthracis str. Ames	neutral protease	567	2e-26	0.25	0.44
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQ---SVDAIGEEGV A E V ++ L + ++ Y V+ ++ G +++++ EG V + H+D +G + SV+G+ + + + ++ +E APENVVKDALKEKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQTYEGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKPINLSKDEAT KKIIAS--------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTL------------------ + I PE K+++F+ N GQ +VT + T + +S Y +NA +G +++ ++ + L QYIYTKYGNDINFISEPEVKEVIFVD-----ENNGQASNAYQVTFEAATPNYISGTYLINAQNGDMLKNMVQESNLKASEKLVGALKKSKKSSLTSLTGT -KNSFQVAFNVPVEK-SNTGIAL------HGTDNTGVYHAVVDGKNNY---SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV K+ ++ + + K SN AL G + V + + + +Y ++ + S + AV A+ V +Y+D + R+S D++G ++SVV GKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKVVSVV ------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQ D P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G+ N +G T HAWDSGDTNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTG SVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDA SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F + R A SV-----FRDMENPTSVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSA MLAAAKVQYGDEAASV--VSAAFNSAGI + A +YG +A V V AF++A I CIRVATNKYGANSAEVQAVQKAFDAAKI
Show aligned area	42779745	Bacillus cereus ATCC 10987	neutral protease	566	3e-26	0.36	0.55
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY++ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKNTFNRNSINDAGAPLKSTV--HYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTENSSNLIYQNESGALNEAISDIFGTLVEFYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY G+ D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSK-----RYTGSS--DNGGVHTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y T FS AR + AA YG +A V V +F++ GI YYTQSTTFSQARAGAVQAAADLYGANSAEVAAVKQSFSAVGI
Show aligned area	118478097	Bacillus thuringiensis str. Al Hakam	extracellular neutral metalloprotease, bacillolysin	581	3e-26	0.25	0.44
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQ---SVDAIGEEGV A E V ++ L + ++ Y V+ ++ G +++++ +G V + H+D +G + SV+G+ + + + ++ +E APENVVKDALKEKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQTYKGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKPINLSKDEAT KKIIAS--------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTL------------------ + I PE K+++F+ N GQ +VT + T + VS Y +NA +G +++ ++ + L QYIYTKYGNDINFISEPEVKEVIFVD-----ENNGQASNAYQVTFEAATPNYVSGTYLINAQNGDMLKNMVQQSNLKASEKLVGALKKSKKSSLTSLTGT -KNSFQVAFNVPVEK-SNTGIAL------HGTDNTGVYHAVVDGKNNY---SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV K+ ++ + + K SN AL G + V + + + +Y ++ + S + AV A+ V +Y+D + R+S D++G ++SVV GKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKVVSVV ------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQ D P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G+ N +G T HAWDSGDTNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTG SVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDA SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F + R A SV-----FRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSA MLAAAKVQYGDEAASV--VSAAFNSAGI + A +YG +A V V AF++A I CIRVATNKYGANSAEVQAVQKAFDAAKI
Show aligned area	222094351	Bacillus cereus Q1	bacillolysin (thermolysin-like metalloprotease, peptidase M4)	566	3e-26	0.36	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTENSSNLIYQNESGALNEAISDIFGTLVEFYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY G+ D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPAKYGDPDHYSK-----RYTGSS--DNGGVHTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y T FS AR + AA YG +A V V +F++ GI YFTQSTTFSQARAGAVQAAADLYGANSAEVAAVKQSFSAVGI
Show aligned area	217958186	Bacillus cereus AH187	neutral protease Npr599	566	3e-26	0.36	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTENSSNLIYQNESGALNEAISDIFGTLVEFYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY G+ D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPAKYGDPDHYSK-----RYTGSS--DNGGVHTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y T FS AR + AA YG +A V V +F++ GI YFTQSTTFSQARAGAVQAAADLYGANSAEVAAVKQSFSAVGI
Show aligned area	52142930	Bacillus cereus E33L	bacillolysin	886	3e-26	0.27	0.45
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVKKIIAS---------DNP L + +S Y V+ ++ G +++++ EG V + H+D+ G + SV+G + K +++ + +E K+ I + P LSPKQVSGDKGVDYKVLQKRGSYDGTTLVRMQQIYEGKEVYGHQLTAHVDKRGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYTKYGNDIKFISEP ETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGT--DNTGVY--- E K+++F+ N GQ +VT ++ T + VS Y V+A +G D+ +++ E LK + ++ K + I+L GT D+ G+ EVKEVIFVD-----ENNGQASNAYQVTFAAATPNYVSGTYLVDAHNG------DMLKNMLQESDLKVREEQVESLRENKKSNSISLTGTGKDDLGITRSF ---------HAVVDGKN---------NYSIIQ-----APSLVALNQN-------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNA +A+ D NY I P ++A + + AV A+ V +Y+D ++R+S D++G ++SVV H D+ GISEQSNGKYALADYTRGQGIETYDVNYRDINFEEQYYPGILATSTSTTFDDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKKVVSVVHAWHSGETDDP FWDGKAMRYGETSTPT---GKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQSVDRKTGIRNLQTPSK G A + G + D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG YI +G N IG + SV +RN++ PS KNWGNAFSANINNVSMLIYGDPMVRAFDIAGHEFTHAVTSSESNLEFFGESGAINEALSDIMGTAIEKYINNGEFNWTIGEQSGSV-----LRNMKNPSS HGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV + + DD +++ D GVH+NS IIN++ Y I Q +G +K IFY + + L + FS+ R A L A +YG + V VKFFDGVPYPDDYSKFSDLNGEDNEGVHFNSSIINKVAYLIAQGGTQNDVTVNGIGEDKMFDIFYYANTDELNMTSNFSELRLACLKVATNKYGANSIEV --VSAAFNSAGIGA--KED--IQVNQPSE V AF++A I KED +VNQ E ETVQKAFDAAKIKGTVKEDEKTEVNQVPE
Show aligned area	86740328	Frankia sp. CcI3	peptidase M4, thermolysin	375	3e-26	0.35	0.49
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS +Y D R SIDD GM +L+ V + D Y+NAFW+G+ M +G+ K + +SLD++GHE+THGVTE A L Y+ QSGALNES SD+ G ++ FYSDVLGRSSIDDEGMALLATV--HYGDHYENAFWNGRQMVFGDGDGELFKRFTASLDIIGHELTHGVTEDEAALMYVNQSGALNESISDVFGSLVKQYV NPEIG-------ADTQSVDRKTGI--RNLQTPSKHGQPETMA---QYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIFYSSL-V + D D G+ R+++ P + Q D RY D GGVH NSGI N+ Y LG EKA I+Y +L RGQTAEQADWLIGDELLTDAVQGVALRSMKAPGTAYDDPVLGDDIQPDHMDRYVRMT-ADNGGVHINSGIPNKAFYLAATALGGYAWEKAGRIWYETLRA NYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKEDIQVN + P F + A + +G +A VS A+ + GI + QV+ PQIRPNTTFRAFASVTVHQAGLLFGADARKAVSEAWQAVGIVVRAAGQVS
Show aligned area	153932555	Clostridium botulinum A str. ATCC 19397	thermolysin metallopeptidase	594	4e-26	0.36	0.52
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA-YDNAFWDGK--AMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA N+VDAY + YY++ R+S+D++GM I V H D NAFW G+ +M +G+ A +LD+VGHE++HGVT + L+Y +SGA NSVDAYANMAKSYDYYKNKLSRNSLDNKGMNIKGFV---HFDKNLGNAFWVGEYDSMFFGDGDGVRLSPLAKALDIVGHELSHGVTNKASNLKYEKESGA LNESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI LNES+SD+MG I G N EIG D G +R+++ PS+ QP M + + D GGVH NSGIIN Y I + +G + ++ I LNESFSDIMGTAIEG-KNFEIGEDCWIPTWFYGEVMRDMKDPSRGRQPAHMKNFRKLPVDRDN---DWGGVHINSGIINHAAYLIANGFEKMGAKDSKDI ----FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGA FY + Y F+ R+ ++ AK YGD + V V AF+ GI A MGKLFYIANCYYWDETTDFAKCRNDVVKVAKDLYGDNSKEVEIVKNAFDQVGITA
Show aligned area	163938524	Bacillus weihenstephanensis KBAB4	thermolysin	566	4e-26	0.36	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSKYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTENSSDLIYQNESGALNEAISDIFGTLVEFYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY G+ D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPSKAGDALRSMSDPAKYGDPDHYSK-----RYTGSS--DNGGVHTNSGIINKQAYLLANGGTHSGVTVTGIGKDKLGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y T FS AR + AA YG +A V V +F++ G+ YFTQSTTFSQARAGAVQAAADLYGASSAEVAAVKQSFSAVGV
Show aligned area	66046272	Pseudomonas syringae pv. syringae B728a	bacillolysin	356	4e-26	0.32	0.49
SIIQAPSLVALNQNAVD-AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPD------AYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTH ++++ A A D AY V +Y F+R+S+DD GM ++S V D NA+W+G M YG+ K + SL+V+GHE+TH AVVRKEGQAATGDKATDEAYDGSGDVYDFYAQLFERNSLDDSGMSLVSTVHVAEVDFNGDHVPLSNAYWNGSQMAYGDGDDLVFKRFTGSLEVIGHELTH GVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSV---------DRKTGIRNLQTPSK----------HGQPETMAQYDDRARYKGTPYY GV T+ L+Y GQSGALNE ++D+ G ++ A++ V + GIR+++ P QP TMA Y G GVQSFTSNLDYRGQSGALNEHFADVFGMLVRQWKQGTSAAESDWVVGKELLVPAPTRRGIRDMEKPGTAYSNDPDLGDDPQPATMADL-----YTGAK-- DQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIFYSSLVNYLTPKAQFSD-ARDAMLAAAKVQYGDEAASVVSAAFNSAGI D+GGVH NSGI NR + + LG E A I+Y +++ L +QF D A+ ++ A+ ++G +A V AA+ G+ DRGGVHINSGIPNRAFVLVAKALGGNAWEVAGRIWYETMLE-LASDSQFIDCAKASIKVASDPRFGPKAKKAVQAAWKEVGL
Show aligned area	75909157	Anabaena variabilis ATCC 29413	peptidase M4, thermolysin	360	4e-26	0.33	0.50
SLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLG S VA+N+ AY + + F+R+SIDD+G+ + S + Y+NAFW+G M YG+ + S+DV+ HE+THG+T+H AGL Y G SDVAVNE----AYDGAGATYDLFYEIFERNSIDDKGLRLDSTI--HFGVKYENAFWNGDQMVYGDGDGELFDRFTKSIDVIAHELTHGITQHEAGLIYYG QSGALNESYSDLMGYIISGASNPEIGADTQSV---------DRKTGIRNLQTPSKHGQPETMAQYDDRARYKG--TPYYDQGGVHYNSGIINRIGYTIIQ + GALNES+SD+ G ++ + + + + G+R+++ P + + K T + D GGVH NSGI NR Y EPGALNESFSDVFGALVKQRVKNQKAEEADWLIGDALLMPNVKGVGVRSMKEPGTAYDDPVLGKDPQPGHVKDQYTGWADNGGVHINSGIPNRAFYLAAV NLG---IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD +G EKA I+Y +L + L KA F+ A D + A YGD EIGGYAWEKAGKIWYIALRDRLRAKADFTKAADVTIQVASELYGD
Show aligned area	218235151	Bacillus cereus B4264	neutral protease Npr599	566	5e-26	0.36	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTENSSNLIYQNESGALNEAISDIFGTLVEFYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY G+ D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSK-----RYTGSS--DNGGVHTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y T FS AR + AA YG +A V V +F++ G+ YFTQSTTFSQARAGAVQAAADLYGANSAEVAAVKQSFSAVGV
Show aligned area	218895656	Bacillus cereus G9842	neutral protease Npr599	566	5e-26	0.36	0.54
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS YY+ F R+SI+D G P+ S V + Y+NAFW+G M YG+ T + + +DV+GHE+TH VTE+++ L Y +SGALNE+ SD+ G ++ YYKATFNRNSINDAGAPLKSTV--HYGSKYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTENSSDLIYQNESGALNEAISDIFGTLVEFYD NP----EIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVN N EIG D + + +R++ P+K+G P+ ++ RY G+ D GGVH NSGIIN+ Y + + +G +K I+Y + NRNPDWEIGEDIYTPGKAGDALRSMSDPAKYGDPDHYSK-----RYTGSS--DNGGVHTNSGIINKQAYLLANGGTHSGVTVTGIGKDKLGAIYYRANTQ YLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI Y T FS AR + AA YG +A V V +F++ G+ YFTQSTTFSQARAGAVQAAADLYGASSAEVNAVKQSFSAVGV
Show aligned area	218903854	Bacillus cereus AH820	metalloendopeptidase	567	5e-26	0.25	0.44
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQ---SVDAIGEEGV A E V ++ L + ++ Y V+ ++ G +++++ EG V + H+D +G + SV+G+ + + + ++ +E APENVVKDALKEKTEQALSPKQVNGETGVDYKVLQKRGSYDGTTLVRIQQTYEGKEVYGHQLTAHVDNSGVIKSVSGDSAQNLKQEELKKPINLSKDEAT KKIIAS--------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTL------------------ + I PE K+++F+ N GQ +VT + T + +S Y +NA +G +++ ++ + L QYIYTKYGNDINFISEPEVKEVIFVD-----ENNGQASNAYQVTFEAATPNYISGTYLINAQNGDMLKNMVQESNLKASEKLVGALKKSKKSSLTSLTGT -KNSFQVAFNVPVEK-SNTGIAL------HGTDNTGVYHAVVDGKNNY---SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV K+ ++ + + K SN AL G + V + + + +Y ++ + S + AV A+ V +Y+D + R+S D++G ++SVV GKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNQGQKVVSVV ------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQ D P + NA +G + YG+ P K Y DV GHE TH VT + LEY G+SGA+NE+ SD+MG Y+ +G+ N +G T HAWDSGDTNDPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTG SVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDA SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ++ +G +K IFY + + L + F + + A SV-----FRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELKSA MLAAAKVQYGDEAASV--VSAAFNSAGI + A +YG +A V V AF++A I CIRVATNKYGANSAEVQAVQKAFDAAKI
Show aligned area	167625393	Shewanella halifaxensis HAW-EB4	peptidase M4 thermolysin	654	6e-26	0.32	0.49
NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL +Q DA+ + YY ++ R SID+ GM + S V + Y+NAFWDG M YG+ T + DVV HE+THGVTE ++GL Y +SGAL DQAIDDAHNYAIATYDYYLNNHGRDSIDNAGMTLKSRV--HYSRNYNNAFWDGSQMTYGDGDGVTFAPLSQDADVVAHELTHGVTERSSGLIYQNESGAL NESYSDLMGYII---SGASNPE---IGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGII---------------NRI NE++SD+ G ++ GA+ + IG D + +RN+ P+ G + Y D RY G+ D GGVH+NSGI N+ NEAWSDIFGAMVDRQEGAAGSDIWLIGEDIYTPGAPGDALRNMADPASMGDYD---YYPD--RYTGSS--DNGGVHWNSGIANLAFQLLVDGGQHPRNKT GYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKV-----QYGDEAASVVSAAFNSAGIGAKEDIQVNQPSE + +G + A IFY++ +N LTP + F+ AR AK Q + + + A+++ G+ + + + P E PEVTVTGIGFDDAAAIFYAANINCLTPSSNFASARYCTALQAKALFDGGQLSSDHQTSIHLAWDAVGVPSNTPPESSTPIE
Show aligned area	218232059	Bacillus cereus B4264	neutral protease	887	7e-26	0.26	0.44
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVK A E V ++ L + +S Y V+ ++ G L++++ EG V + H+D+ G + S++G + + ++ + +E K APENVVKDALKENTEHALSPKQVSAETGVDYKVLQKRGSYDGTTLLRMQQIYEGKEVYGHQLTAHVDKKGIIKSISGASAQNLTQEDLKKPINLSKEEAK KIIAS---------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTG + I PE K ++F+ N GQ +VT ++ T + VS Y VNA +G ++ +D+ + E +LK S + +V K++ QYIYKKYGNDTKFISEPEVKAVIFVD-----ENHGQASNAYQVTFAATTPNYVSGTYLVNAHNGEML--KDMVQ----ESSLKISEEYVESVKENKTSNF IALHGT--DNTGV-------------------------------YHAVVDGKNNYSIIQAPSLVAL--NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGM +L GT D+ GV Y + + ++ Y I A S + AV A+ V +Y++ ++R+S D++G TSLTGTGKDDLGVTRTFGISKQTSGNYALADYTRGQGIETYDVNYRDITNEESYYPGILATSASTTFNDPKAVSAHFLATKVYDFYKEKYKRNSFDNKGK PILSVVDE------QHPDAYDNAFWDG----KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASN ++SVV P+ ++NAF + YG+ P K + D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG YI +G N KVVSVVHAWDSGGTNDPENWENAFSTNINNISMLLYGD---PMVKAF----DIAGHEFTHAVTSSESNLEFSGESGAINEALSDIMGTAIEKYINNGEFN PEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKA IG T S RN++ P+ E + DD ++Y D GGVH+NS IIN++ Y + Q +G ++ IFY + + L + WTIGEQTGST-----FRNMKNPTAINFSEGLPYPDDYSKYNDLNGEDYGGVHFNSSIINKVAYLMAQGGTHNGVNVNGIGEDRMFDIFYYANTDELNMTS QFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI FS+ + A L A +YG + V V AF++A I NFSELKLACLKVATNKYGANSIEVQAVQNAFDAAKI
Show aligned area	30020634	Bacillus cereus ATCC 14579	bacillolysin	893	8e-26	0.26	0.44
AEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVK A E V ++ L + +S Y V+ ++ G +++++ EG V + H+D+ G + S++G + + ++ + +E K APENVVKDALKENTEHALSPKQVSAETGVDYKVLQKRGSYDGTTLVRMQQIYEGKEVYGHQLTAHVDKKGIIKSISGASAQNLTQEDLKKPINLSKEEAK KIIAS---------DNPETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTG + I PE K ++F+ N GQ +VT ++ T + VS Y VNA +G ++ +D+ + E +LK S + +V K++ QYIYKKYGNDTKFISEPEVKAVIFVD-----ENHGQASNAYQVTFAATTPNYVSGTYLVNAHNGEML--KDMVQ----ESSLKISEEYVESVKENKTSNF IALHGT--DNTGV-------------------------------YHAVVDGKNNYSIIQAPSLVAL--NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGM +L GT D+ GV Y + + ++ Y I A S+ + AV A+ V +Y++ ++R+S D++G TSLTGTGKDDLGVTRTFGISKQTSGNYALADYTRGQGIETYDVNYRDITNEESYYPGILATSVSTTFNDPKAVSAHFLATKVYDFYKEKYKRNSFDNKGK PILSVVDE------QHPDAYDNAFWDG----KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASN ++SVV P+ ++NAF + YG+ P K + D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG YI +G N KVVSVVHAWDSGGTNDPENWENAFSTNINNISMLLYGD---PMVKAF----DIAGHEFTHAVTSSESNLEFSGESGAINEALSDIMGTAIEKYINNGEFN PEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKA IG T S RN++ P+ E + DD ++Y D GGVH+NS IIN++ Y + Q +G ++ IFY + + L + WTIGEQTGST-----FRNMKNPTAINFSEGLPYPDDYSKYNDLNGEDYGGVHFNSSIINKVAYLMAQGGTHNGVNVNGIGEDRMFDIFYYANTDELNMTS QFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI FS+ + A L A +YG + V V AF++A I NFSELKLACLKVATNKYGANSIEVQAVQNAFDAAKI
Show aligned area	170761784	Clostridium botulinum A3 str. Loch Maree	thermolysin metallopeptidase	592	1e-25	0.35	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA-YDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA N+VDAY + YY++ R+SID++GM + V H D NAFW G +M +G+ A SLDVVGHE++HGVT + L Y +SGA NSVDAYVNTAKTYDYYKNKLSRNSIDNKGMNVNGFV---HVDKNLGNAFWYGPYDSMFFGDGDGVRFSALAKSLDVVGHELSHGVTNKQSNLNYANESGA LNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI-- LNES+SD+MG + G N +G D +R+++ P++ QP M Y + D GGVH NSGIIN Y I + +G + ++ I LNESFSDIMGTAVEG-KNFVLGEDCWIAGGV--MRDMENPARGNQPAHMKDYAYMSE-------DNGGVHKNSGIINHAAYLIADGFEKMGAKDSKDIMG --FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGAKEDIQV FY + Y F+ R+ ++ AK YGD + V V AF+ G+ A + + KLFYIANCYYWDQTTDFAKCRNDVVRVAKDLYGDNSKEVEIVKNAFDKVGVSATPQLSL
Show aligned area	17228478	Nostoc sp. PCC 7120	hypothetical protein all0983	360	1e-25	0.33	0.50
SLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLG S VA+N+ AY + + F+R+SIDD+G+ + S + Y+NAFW+G M YG+ + S+DV+ HE+THG+T++ AGL Y G SDVAVNE----AYDGAGATYDLFYEIFERNSIDDKGLRLDSTI--HFGIKYENAFWNGDQMVYGDGDGELFDRFTKSIDVIAHELTHGITQYEAGLIYYG QSGALNESYSDLMGYIISGASNPEIGADTQSVD---------RKTGIRNLQTPSKHGQPETMAQYDDRARYKG--TPYYDQGGVHYNSGIINRIGYTIIQ + GALNES+SD+ G ++ N + + + + G+R+++ P + + K T + D GGVH NSGI NR Y EPGALNESFSDVFGALVKQRVNNQKAEEADWLIGDALLMPKVKGVGVRSMKEPGTAYDDPILGKDPQPGHVKDQYTGWADNGGVHINSGIPNRAFYLAAV NLG---IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD +G EKA I+Y +L + L KA F A D + A YGD EIGGYAWEKAGKIWYIALRDRLRAKADFIKAADVTIQVASELYGD
Show aligned area	153938859	Clostridium botulinum F str. Langeland	thermolysin metallopeptidase	592	1e-25	0.35	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA-YDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA N+VDAY + YY++ R+SID++GM + V H D NAFW G +M +G+ A SLDVVGHE++HGVT + L Y +SGA NSVDAYVNTAKTYDYYKNKLSRNSIDNKGMNVNGFV---HVDKNLGNAFWYGPYDSMFFGDGDGVRFSALAKSLDVVGHELSHGVTNKQSDLNYENESGA LNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI-- LNES+SD+MG + G N +G D +R+++ PS+ QP M Y + D GGVH NSGIIN Y I + +G + ++ I LNESFSDIMGTAVEG-KNFVLGEDCWIAGGV--MRDMENPSRGNQPAHMKDYAYMSE-------DNGGVHKNSGIINHAAYLIADGFEKMGTKDSKDIMG --FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGAKEDIQV FY + Y F+ R+ ++ AK YGD + V V AF+ G+ A + + KLFYIANCYYWDQTTDFAKCRNDVVRVAKDLYGDNSKEVEIVKTAFDKVGVYATPQLSL
Show aligned area	158313880	Frankia sp. EAN1pec	peptidase M4 thermolysin	353	2e-25	0.34	0.49
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS ++ D + R S+DD GM +L+ V + D Y+NAFW+G+ M +G+ + SLD++GHE+ HGVTE A L YL QSGALNES SD+ G ++ FFLDAYGRDSVDDDGMGLLATV--HYGDHYENAFWNGRQMVFGDGDGELFNRFTVSLDIIGHELAHGVTEDEAQLMYLNQSGALNESLSDVFGSLVKQHL NPEIGAD----------TQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKG--TPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIFYSSL-V + D T +V + +R+++ P + A G D GGVH NSGI N+ YT+ LG E+A I+Y +L RGQTAEDADWLIGEGLLTDAV-QGVALRSMKEPGTAYDDPVLGDDIQPAHMDGYVRTTTDNGGVHINSGIPNKAFYTLAVALGGHAWERAGRIWYEALRA NYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI L P A F A A+V +G E V A+ S G+ PQLRPNATFRSFAAATSRQAQVLFGPEETQAVRDAWASVGV
Show aligned area	170756874	Clostridium botulinum B1 str. Okra	thermolysin metallopeptidase	592	2e-25	0.35	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA-YDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA N+VDAY + YY++ R+SID++GM + V H D NAFW G +M +G+ A SLDVVGHE++HGVT + L Y +SGA NSVDAYVNTAKTYDYYKNKLSRNSIDNKGMNVNGFV---HVDKNLGNAFWYGPYDSMFFGDGDGVRFSALAKSLDVVGHELSHGVTNKQSDLNYENESGA LNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI-- LNES+SD+MG + G N +G D +R+++ PS+ QP M Y + D GGVH NSGIIN Y I + +G + ++ I LNESFSDIMGTAVEG-KNFVLGEDCWIAGGV--MRDMENPSRGNQPAHMKDYAYMSE-------DNGGVHKNSGIINHAAYLIADGFEKMGTKDSKDIMG --FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGAKEDIQV FY + Y F+ R+ ++ AK YGD + V V AF+ G+ A + + KLFYIANCYYWDQTTDFAKCRNDVVRVAKDLYGDNSKEVEIVKNAFDKVGVYATPQLSL
Show aligned area	29832143	Streptomyces avermitilis MA-4680	metalloprotease	356	2e-25	0.37	0.51
YEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS---- Y + R+SI+ G+P+ + V + Y+NAFW+G+ M +G+ + +DV+GHE+THGVT++TA L Y GQ GALNES SD+ G +I YLSAYTRNSINGEGLPLTATV--HFDENYNNAFWNGEQMVFGDGDGEIFLDFTIPVDVIGHELTHGVTQYTANLTYFGQPGALNESMSDVFGSLIKQYTL GASNPE----IGADTQSVDRKTG--IRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIF G + E IGA + R TG +R+++ P K QP TM Y R D GGVH NSGI N Y + LG E+A I+ GQTATEADWLIGAGLLA-PRVTGTALRSMKEPGSAYDDDLLGKDPQPGTMDGYVRTGR-------DNGGVHINSGIPNHAFYLVANTLGGHAWERAGQIW YSSLV-NYLTPKAQFSDARDAMLAAAKVQYGD-EAASVVSAAFNSAGI Y L L +A F+D +AAAK +YGD E V A+ G+ YDVLTGGELQSQASFADFAKLTVAAAKARYGDGEEQQGVLKAWEQVGV
Show aligned area	153935843	Clostridium botulinum A str. Hall	thermolysin metallopeptidase	592	2e-25	0.35	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA-YDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA N+VDAY + YY++ R+SID++GM + V H D NAFW G +M +G+ A SLDVVGHE++HGVT + L Y +SGA NSVDAYVNTAKTYDYYKNKLSRNSIDNKGMNVNGFV---HVDKNLGNAFWYGPYDSMFFGDGDGVRFSALAKSLDVVGHELSHGVTNKQSNLNYANESGA LNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI-- LNES+SD+MG + G N +G D +R+++ PS+ QP M Y + D GGVH NSGIIN Y I + +G + ++ I LNESFSDIMGTAVEG-KNFVLGEDCWIAGGV--MRDMENPSRGNQPAHMKDYVYMSE-------DNGGVHKNSGIINHAAYLIADGFEKMGAKDSKDIMG --FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGAKEDIQV FY + Y F+ R+ ++ AK YG+ + V V AF+ G+ A + + KLFYIANCYYWDQTTDFAKCRNDVVRVAKDLYGENSKEVQIVKNAFDKVGVSATPQLSL
Show aligned area	153931486	Clostridium botulinum A str. ATCC 19397	thermolysin metallopeptidase	592	2e-25	0.35	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA-YDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA N+VDAY + YY++ R+SID++GM + V H D NAFW G +M +G+ A SLDVVGHE++HGVT + L Y +SGA NSVDAYVNTAKTYDYYKNKLSRNSIDNKGMNVNGFV---HVDKNLGNAFWYGPYDSMFFGDGDGVRFSALAKSLDVVGHELSHGVTNKQSNLNYANESGA LNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI-- LNES+SD+MG + G N +G D +R+++ PS+ QP M Y + D GGVH NSGIIN Y I + +G + ++ I LNESFSDIMGTAVEG-KNFVLGEDCWIAGGV--MRDMENPSRGNQPAHMKDYVYMSE-------DNGGVHKNSGIINHAAYLIADGFEKMGAKDSKDIMG --FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGAKEDIQV FY + Y F+ R+ ++ AK YG+ + V V AF+ G+ A + + KLFYIANCYYWDQTTDFAKCRNDVVRVAKDLYGENSKEVQIVKNAFDKVGVSATPQLSL
Show aligned area	148379415	Clostridium botulinum A str. ATCC 3502	secreted protease	592	2e-25	0.35	0.51
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA-YDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA N+VDAY + YY++ R+SID++GM + V H D NAFW G +M +G+ A SLDVVGHE++HGVT + L Y +SGA NSVDAYVNTAKTYDYYKNKLSRNSIDNKGMNVNGFV---HVDKNLGNAFWYGPYDSMFFGDGDGVRFSALAKSLDVVGHELSHGVTNKQSNLNYANESGA LNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI---IQNLGIEKAQTI-- LNES+SD+MG + G N +G D +R+++ PS+ QP M Y + D GGVH NSGIIN Y I + +G + ++ I LNESFSDIMGTAVEG-KNFVLGEDCWIAGGV--MRDMENPSRGNQPAHMKDYVYMSE-------DNGGVHKNSGIINHAAYLIADGFEKMGAKDSKDIMG --FYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGAKEDIQV FY + Y F+ R+ ++ AK YG+ + V V AF+ G+ A + + KLFYIANCYYWDQTTDFAKCRNDVVRVAKDLYGENSKEVQIVKNAFDKVGVSATPQLSL
Show aligned area	21220989	Streptomyces coelicolor A3(2)	metalloprotease	356	2e-25	0.34	0.50
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS +Y + ++R SID G+P+ + V + Y+NAFW+G+ M +G+ + +LDV+GHE+THGVT+HTA L Y GQ GALNES SD+ G +I + HYLEVYRRDSIDGAGLPLDATV--HYDREYNNAFWNGEQMVFGDGDGEIFLDFTVALDVIGHELTHGVTQHTANLTYYGQPGALNESVSDVFGSLIKQYA NPEIGADTQSV-------DRKTG--IRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIF + A+ + R TG +R+++ P K QP TM + R D GGVH NSGI N Y + LG E+A ++ QGQTAAEADWLIGAGLLAPRVTGEALRSMKAPGTAYDDDVLGKDPQPATMDDFVRTGR-------DNGGVHINSGIPNHAFYLLATALGGHAWERAGQLW YSSLV-NYLTPKAQFSDARDAMLAAAKVQYGD-EAASVVSAAFNSAGI Y L L A F+D + AA+ +YGD + V A+ G+ YDVLTGGELAEDALFADFATLTVKAARERYGDGDELEAVGKAWEQVGV
Show aligned area	78045631	Xanthomonas campestris pv. vesicatoria str. 85-10	Zinc metalloprotease	354	4e-25	0.36	0.49
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYS +AY + +++ + R+SID GMP++ V + YDNAFW+G+ M +G+ T A LDVVGHE+THGVTE TA L Y GQSGALNES S EAYDYLGATHDFFQTVYGRNSIDAAGMPLIGSV--HYERGYDNAFWNGEQMVFGDGEVFNRFTIA--LDVVGHELTHGVTERTANLIYQGQSGALNESIS DLMGYII--------SGASNPEIGADTQSVDRK-TGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG D+ G +I + ++ IGA K G+R++Q P K QP TMA Y D D GGVHYNSGI N Y +G DVFGVLIKQYTLRQSADQADWIIGAGLLMPGIKGVGLRSMQAPGSAYDDPALGKDPQPATMAGYVDTQE-------DDGGVHYNSGIPNHAFYRAAVAIG ---IEKAQTIFYSSLV-NYLTPKAQFSDARDAMLAAAKVQYGDEAA--SVVSAAFNSAGIGA EK I+Y +L L A F+ + A +YG ++ + V A+ G+ A GAAWEKTGRIWYRALTGGELAAGADFATFAALTVEVASAEYGANSSETAAVQQAWRDVGVLA
Show aligned area	111224002	Frankia alni ACN14a	metalloprotease	368	5e-25	0.35	0.49
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGAS +Y + F R SIDD G+ +L+ V + D YDNAFW+G+ M +G+ + + SLD++GHE+THGVTE A L Y+ QSGALNES SD+ G ++ + FYSEVFGRDSIDDEGVGLLASV--HYGDHYDNAFWNGRQMVFGDGDGELFQRFTVSLDIIGHELTHGVTEDEAALMYVNQSGALNESVSDVFGSLVKQYA NPEIGADTQSVDRKTG------------IRNLQTPSKHGQPETMAQYDDRARYKGTPYY----DQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIFYS +G + D G +R+L+ P + DD T Y D GGVH NSGI N+ Y LG E+A I+Y ---LGQTAEQADWLIGDELLTDAVQGVALRSLKDPGTAYDDPVLG--DDIQPAHMTGYVQMTGDNGGVHINSGIPNKAFYLAAIALGGYAWERAGRIWYE SL-VNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIG SL + P A F A A V +G + V+ A+ GI SLRAPQVRPNATFRSFAAATRRQAGVLFGADERKAVTEAWREVGIA
Show aligned area	159896969	Herpetosiphon aurantiacus ATCC 23779	peptidase M4 thermolysin	1017	6e-25	0.33	0.49
ALNQNAVDA-YTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA---YDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYL A N +DA Y + ++ F R+SID+ GM ++S+V P A Y NAFW+G+ M YG+ +A++ DVV HE++HGVTE+T+ L Y ASNDADIDAAYDYSGDTYDFFNLFFGRNSIDNNGMNLISLVKHCPPGAGCPYGNAFWNGRQMTYGQG-------FAAADDVVAHELSHGVTEYTSNLFYY GQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKT------GIRNLQTPSKHGQPETMAQYDDRARYKGTP-YYDQGGVHYNSGIINRIGYTI----- QSGA+NE+ SD+ G + + AD R GIRN+Q P++ QP+ M Y P D GGVH NSG+ N+ Y + FQSGAINEAMSDIFGEFMDQTNG---SADDDETTRWIMGEDLGGIRNMQDPTQGDQPDRMLS----ELYVLDPNLLDSGGVHSNSGVANKAAYLLSDGDT -----IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKEDIQVNQ I ++GI K +FY + ++ LT + ++D A+ A G S GI A + ++VN+ FNGQTIASIGITKTAHLFYETQISSLTSGSDYADLASALRQACTSLTG------------SHGITAADCVEVNK
Show aligned area	21229554	Xanthomonas campestris pv. campestris str. ATCC 33913	metalloprotease	358	7e-25	0.34	0.46
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYS +AY + +++ + R+SIDD GMP+L V + YDNAFW G+ M +G+ + ++DVV HE+THGV E TA L Y GQSGALNES S EAYDYLGATHAFFQQVYARNSIDDAGMPLLGTV--HYERNYDNAFWTGEQMVFGDGDGEIFTRFTIAIDVVAHELTHGVIERTANLIYQGQSGALNESVS DLMGYIISGASNPEIGADTQSVDRKTG------------IRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRI---GYT D+ G ++ + + D D G +R++Q P K QP M Y D D GGVHYNSGI NR DVFGVLVKQYA---LRQDAAQADWLVGAGMFLPGVQGVALRSMQAPGTAYDDPALGKDPQPAHMDAYVDTQE-------DDGGVHYNSGIPNRAFQRAAV IIQNLGIEKAQTIFYSSLV-NYLTPKAQFSDARDAMLAAAKVQY--GDEAASVVSAAFNSAGIGA I EKA I+Y +L L+ A F+ + A Y G AS V A+ G+ A AIGGYAWEKAGRIWYRALTGGALSASADFATFAALTVRVASTDYGAGSAEASAVEQAWRDVGVLA
Show aligned area	66766427	Xanthomonas campestris pv. campestris str. 8004	metalloprotease	358	7e-25	0.34	0.46
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYS +AY + +++ + R+SIDD GMP+L V + YDNAFW G+ M +G+ + ++DVV HE+THGV E TA L Y GQSGALNES S EAYDYLGATHAFFQQVYARNSIDDAGMPLLGTV--HYERNYDNAFWTGEQMVFGDGDGEIFTRFTIAIDVVAHELTHGVIERTANLIYQGQSGALNESVS DLMGYIISGASNPEIGADTQSVDRKTG------------IRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRI---GYT D+ G ++ + + D D G +R++Q P K QP M Y D D GGVHYNSGI NR DVFGVLVKQYA---LRQDAAQADWLVGAGMFLPGVQGVALRSMQAPGTAYDDPALGKDPQPAHMDAYVDTQE-------DDGGVHYNSGIPNRAFQRAAV IIQNLGIEKAQTIFYSSLV-NYLTPKAQFSDARDAMLAAAKVQY--GDEAASVVSAAFNSAGIGA I EKA I+Y +L L+ A F+ + A Y G AS V A+ G+ A AIGGYAWEKAGRIWYRALTGGALSASADFATFAALTVRVASTDYGAGSAEASAVEQAWRDVGVLA
Show aligned area	188989480	Xanthomonas campestris pv. campestris str. B100	Zinc metalloprotease	354	8e-25	0.34	0.46
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYS +AY + +++ + R+SIDD GMP+L V + YDNAFW G+ M +G+ + ++DVV HE+THGV E TA L Y GQSGALNES S EAYDYLGATHAFFQQVYARNSIDDAGMPLLGTV--HYERNYDNAFWTGEQMVFGDGDGEIFTRFTIAIDVVAHELTHGVIERTANLIYQGQSGALNESVS DLMGYIISGASNPEIGADTQSVDRKTG------------IRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRI---GYT D+ G ++ + + D D G +R++Q P K QP M Y D D GGVHYNSGI NR DVFGVLVKQYA---LRQDAAQADWLVGAGMFLPGVQGVALRSMQAPGTAYDDPALGKDPQPAHMDAYVDTQE-------DDGGVHYNSGIPNRAFQRAAV IIQNLGIEKAQTIFYSSLV-NYLTPKAQFSDARDAMLAAAKVQY--GDEAASVVSAAFNSAGIGA I EKA I+Y +L L+ A F+ + A Y G AS V A+ G+ A AIGGYAWEKAGRIWYRALTGGALSASADFATFAALTVRVASTDYGAGSAEASAVEQAWRDVGVLA
Show aligned area	220913107	Arthrobacter chlorophenolicus A6	peptidase M4 thermolysin	350	1e-24	0.36	0.50
AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNES A +AY Y D F R SID RG+P+ + V YDNAFWDGK M +G+ + + +SL V+GHE+ HGVT+ +AGL Y Q+GALNES ADEAYDGLGHTHRLYADVFGRDSIDGRGLPMDATV--HFGRLYDNAFWDGKQMVFGDGDGAVFQRFTASLSVIGHELAHGVTQFSAGLAYRNQAGALNES YSDLMGYIIS----GASNPEI------GADTQSVDRKTGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ SD+ G ++ G S E G T V + +R+++ P K QP++M Y + D GGVH NSGI NR Y + Q MSDVFGALVEQYVKGQSAAEASWLIGEGLFTPEV-QGQALRSMKAPGTAYDDDVLGKDPQPDSMDGYVRTSA-------DNGGVHINSGIPNRAFYLVAQ NLG---IEKAQTIFYSSLVNYLTP-KAQFSDARDAMLAAAKVQYGDEA LG + I+Y +L P A F+ A LAAA+ +G ++ ALGGNAWDAPGRIWYETLTGGSLPTTATFAVFARATLAAAEELFGSDS
Show aligned area	217960020	Bacillus cereus AH187	bacillolysin	891	1e-24	0.26	0.44
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVKKIIAS---------DNP L + +S Y V+ ++ G +++++ EG V + H+D+ G + SV+G + K +++ + +E K+ I + LSPKQVSGDKGVDYKVLQKRGSYDGTTLVRMQQIYEGKEVYGHQLTAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYTKYGNDIQFISEA ETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIM----EKQDLTEHVGSEVTLKNSFQVAFNVPV----------------EKS E K+++F+ N GQ +VT ++ T + VS Y V+A G ++ ++ DL + ++ S + F E+S EVKEVIFVD-----ENRGQATNAYQVTFAAATPNYVSGTYLVDAHSGDMLKNMVQESDLKVNEERVEAIQESKKSNFKSLTGTGKDDLGITRTFGISEQS NTGIAL------HGTDNTGVYHAVVDGKNNY--SIIQAPSLVALNQ-NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV------DEQHPDAYDNA N AL G + V + + + Y I+ + N AV A+ V +Y+D ++R+S D++G ++SVV + P + NA NGKYALADYTRGQGIETYDVNYRDITFEEKYYPGILTTSTSTTFNDPKAVSAHFLATNVYDFYKDKYKRNSFDNKGKKVVSVVHAWDSGETSDPKNWGNA FWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQ F A + G S D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG YI +G N IG + SV +RN++ PS F---SANINNVSMLIYGDPMVRSFDIAGHEFTHAVTSSESNLEFFGESGAINEALSDIMGTAIEKYINNGEFNWTIGEQSGSV-----LRNMKNPSSVKF PETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--V + DD ++Y D GVH+NS IIN++ Y I Q +G +K IFY + + L + FS+ R A L A +YG + V V FNGVPYPDDYSKYSDLNGEDNEGVHFNSSIINKVAYLIAQGGTHNGVTVNGIGEDKMFDIFYYANTDELNMTSNFSELRLACLKVATNKYGANSIEVETV SAAFNSAGIGAKEDIQVNQPSESVLVNE AF++A I K ++ N+ +E+ V E QKAFDAAKI--KGTVKENEKTEANQVPE
Show aligned area	153936914	Clostridium botulinum A str. Hall	thermolysin metallopeptidase	594	2e-24	0.35	0.50
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA-YDNAFWDGK--AMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGA N+VDAY + YY++ R+S+D++GM I V H D NAFW G+ +M +G+ A +LD+VGHE++HGVT + L+Y +SGA NSVDAYANMAKSYDYYKNKLSRNSLDNKGMNIKGFV---HFDKNLGNAFWVGEYDSMFFGDGDGVRLSPLAKALDIVGHELSHGVTNKASNLKYEKESGA LNESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQT---- LNES+SD+MG I G N EIG D G +R+++ PS+ QP M + + D GGVH NSGIIN Y I G EK LNESFSDIMGTAIEG-KNFEIGEDCWIPTWFYGEVMRDMKDPSRGRQPAHMKNFRKLPVDRDN---DWGGVHINSGIINHAAYLIAN--GFEKTGAKNSK -----IFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA--ASVVSAAFNSAGIGA IFY++ F+ R+ ++ K YG+ + +V AF+ GI A DIMGKIFYTANCYKWDETTNFAKCRNDVVQVTKELYGENSNYVKIVEKAFDQVGITA
Show aligned area	222096105	Bacillus cereus Q1	bacillolysin (neutral protease)	891	2e-24	0.26	0.44
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK--IQSVDAIGEEGVKKIIAS---------DNP L + +S Y V+ ++ G +++++ EG V + H+D+ G + SV+G + K +++ + +E K+ I + LSPKQVSGDKGVDYKVLQKRGSYDGTTLVRMQQIYEGKEVYGHQLTAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYTKYGNDIQFISEA ETKDLVFLAIDKRVNNEGQLFYKVRVT-SSPTGDPVSLVYKVNATDGTIM----EKQDLTEHVGSEVTLKNSFQVAFNVPV----------------EKS E K+++F+ N GQ +VT ++ T + VS Y V+A G ++ ++ DL + ++ S + F E+S EVKEVIFVD-----ENRGQATNAYQVTFAAATPNYVSGTYLVDAHSGDMLKNMVQESDLKVNEERVEAIQESKKSNFKSLTGTGKDDLGITRTFGISEQS NTGIAL------HGTDNTGVYHAVVDGKNNY--SIIQAPSLVALNQ-NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV------DEQHPDAYDNA N AL G + V + + + Y I+ + N AV A+ V +Y+D ++R+S D++G ++SVV + P + NA NGKYALADYTRGQGIETYDVNYRDITFEEKYYPGILTTSTSTTFNDPKAVSAHFLATNVYDFYKDKYKRNSFDNKGKKVVSVVHAWDSGETSDPKNWGNA FWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQ F A + G S D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG YI +G N IG + SV +RN++ PS F---SANINNVSMLIYGDPMVRSFDIAGHEFTHAVTSSESNLEFFGESGAINEALSDIMGTAIEKYINNGEFNWTIGEQSGSV-----LRNMKNPSSVKF PETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--V + DD ++Y D GVH+NS IIN++ Y I Q +G +K IFY + + L + FS+ R A L A +YG + V V FNGVPYPDDYSKYSDLNGEDNEGVHFNSSIINKVAYLIAQGGTHNGVTVNGIGEDKMFDIFYYANTDELNMTSNFSELRLACLKVATNKYGANSIEVETV SAAFNSAGIGAKEDIQVNQPSESVLVNE AF++A I K ++ N+ +E+ V E QKAFDAAKI--KGTVKENEKTEANQVPE
Show aligned area	161502330	Salmonella enterica subsp. arizonae serovar 62:z4,z23:--	hypothetical protein SARI_00363	361	2e-24	0.33	0.50
AVD-AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE AVD AY + ++ + R S+D++G+ + V + Y NAFW+G+ M +G+ + SS+DVV HE+THGVTE AGL Y GQSGALNE AVDEAYNYLGITHDFFWKIYHRDSLDNKGLALTGTV--HYGRDYQNAFWNGQQMVFGDGDGEIFNRFTSSIDVVAHELTHGVTETEAGLIYFGQSGALNE SYSDLMGYII--------SGASNPEIGAD--TQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKG--TPYYDQGGVHYNSGIINRIGYTIIQNLG--- S SD++G ++ +G ++ IG + ++ K G+R++ P + Q A + D GGVH NSGI NR Y +G SLSDVLGSLVKQFHLQQTAGQADWIIGEGLLAKGINGK-GLRSMAAPGTAYDDPLLGQDPQPAHMQNFIKTREDNGGVHLNSGIPNRAFYLAACQIGGYA IEKAQTIFYSSLVNY-LTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI EKA +Y +L + L A F+D +A + + G AS + A+ + G+ WEKAGYAWYDTLCDRNLAQNASFADFAGLTIAHGEKRSGQTVASAIEQAWKTVGV
Show aligned area	37525338	Photorhabdus luminescens subsp. laumondii TTO1	hypothetical protein plu1382	365	3e-24	0.36	0.54
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYS +AY + + +Y++ F R+S+DD+GM +++ V + + Y NAFW M +G+ T + +S+DV+GHE++HGV E TA L Y QSGALNES + NAYRYLEATYNFYKEVFNRNSLDDKGMKLIATV--HYGEEYMNAFWGNGQMVFGDGDGKTFNDFTTSVDVIGHELSHGVIEKTADLVYFFQSGALNESIA DLMG------YIISGASNPE--IGADTQSVDRK-TGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG D+ G Y+ A + IG++ D K GIR+++ P K QP M Y D Y+ D GGVH NSGI N+ Y + LG DVFGTLVKQHYLKQKAEEADWIIGSELLGKDVKGVGIRSMKNPGSAYDDKELGKDPQPGHMDDYKDLPIYR-----DNGGVHINSGIPNKAFYNLAIKLG ---IEKAQTIFYSSLVN E+A I+Y++L++ GYAWERAGKIWYNTLLD
Show aligned area	163856791	Bordetella petrii DSM 12804	putative metalloprotease	352	3e-24	0.34	0.50
AVD-AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE AVD AY H + ++RHSID+ G+P++ V + + YDNAFW+G M +G+ + ++D+VGHE++HGV +H AGL Y GQSGALNE AVDEAYEHLGATYDMFWQVYRRHSIDNAGLPLVGTV--HYGEDYDNAFWNGAQMVFGDGDGEVFNRFTVAVDIVGHELSHGVIDHEAGLRYQGQSGALNE SYSDLMGYII----SGASNPE----IGAD--TQSVDRKTGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTII S SD+ G ++ +G + + IGA T +V+ + +R++ P K QP M Y D D GGVH NSGI NR Y SLSDVFGSLVKQHRAGQTADQADWLIGAGLFTSAVNAR-ALRSMAQPGSAYDDPALGKDPQPAHMQDYVDTTD-------DNGGVHINSGIPNRAFYLAA QNLG---IEKAQTIFYSSLVN-YLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI LG ++A ++Y +L + L +A F+ L AA A V A+ G+ TALGGPAWQRAGRVWYDALRDKRLGAQADFASFATLTLEAASADAATRQA--VREAWRQVGV
Show aligned area	28870347	Pseudomonas syringae pv. tomato str. DC3000	thermolysin metallopeptidase, putative	356	4e-24	0.33	0.50
QAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPD------AYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTE QAP+ ++ A +AY V +Y F+R+S+DD GM ++S V D NA+W+G M YG+ K + SL+V+GHE+THGV QAPTG---DKAADEAYDGSGDVYDFYAQLFERNSLDDNGMSLVSTVHVAEVDFNGDHVPLSNAYWNGSQMAYGDGDDLVFKRFTGSLEVIGHELTHGVQS HTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSV---------DRKTGIRNLQTPSK----------HGQPETMAQYDDRARYKGTPYYDQGG T+ L+Y GQSGALNE ++D+ G ++ A++ V + GIR+++ P QP TMA YKG D+GG FTSNLDYKGQSGALNEHFADVFGMLVRQWKQGTSAAESDWVVGKELLVPAPTRRGIRDMERPGTAYANDPDLGDDPQPATMADL-----YKGAK--DRGG VHYNSGIINRIGYTIIQNLG---IEKAQTIFYSSLVNYLTPKAQFSD-ARDAMLAAAKVQYG VH NSGI NR + + LG E A I+Y +++ L +QF D A+ ++ A ++G VHINSGIPNRAFVLVAKALGGNAWEVAGRIWYETMLA-LESDSQFVDCAKTSIKIAGDSRFG
Show aligned area	20090921	Methanosarcina acetivorans C2A	hypothetical protein MA2075	786	5e-24	0.26	0.47
DAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTS-----VTGNPVDQVVKIQSVDAIGEEGVKKIIASDN----PETKDLVFLAIDKRVNNEGQLFYK D G H+ + EG+ V +V +H++ G V + +T PV KI+ +AI E V++ I S+ P ++ ++F + R K DFSGFHHVIFLQHVEGIPVFEGSVQVHINPAGEVIAYKDFRLTEVPVVLEPKIKREEAI--EIVRRDIGSERAVTVPRSRLMLFRDGETRFPTNDFQLNK VRVTSSPTGDPVSLVYKVNA--TDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVD + + P + + LV++V + G + + H G ++ +F S AL T +++ G+ + + + +A ++ A LHL-KKPRLNKLHLVWQVESIFAKGFAGKFHFIDAHTGEQLY---TF----------SQIRSALFRKTYTAKNESILPGE-----LLSENRMATDEVARA AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESY A+ + V YY++ F R S D++G P++S V Y+N+FW K + +G+ + A +LD+V HE+TH V TA Y ++GAL+ES+ AHENMGIVYDYYKNTFGRESYDNKGSPLVSSV--HFLLNYNNSFWSDYHKQLVFGDGDGFRWRPMAFALDIVAHELTHAVAGQTARFVYSEEAGALDESF SDLMGYIISGA---SNPEIGADTQS-VDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTP--YYDQGG-VHYNSGIINRIGYTIIQ---NLGIE----- +D+ IS N EIG + +R+L P + GQP+ + Y R P + +Q G +H NSGI+N+ Y I+ + GI+ ADVFATFISNEGKIKNWEIGEGVYTPFHPGDALRDLSDPPRFGQPDHIDNY-VRLAPGEIPDLHKNQAGYIHLNSGILNKAAYLTIKGGTHYGIKVKGIS --KAQTIFYSSLVNYLT----PKAQFSDARDAMLAAAKVQYGDEAA--SVVSAAFNSAGIGAKEDI +A+ I+Y +L YL + +F +AR A+L A + YG++ + + A+ + G+G ED+ RARAEKIYYLALTAYLCSATLSRWRFREARYALLNACRQLYGEKGPEYAAIKNAWAAVGLGKPEDL
Show aligned area	108762324	Myxococcus xanthus DK 1622	M4 family peptidase	725	8e-24	0.32	0.49
NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL N+ AVDA+ G+ + Y +D R SID G ++S V + Y NA+WDG+ M YG+ ++LD+ GHE+ HG+TE TAGL Y G+SG L NKAAVDAHYGGQMMYDYMKDILGRDSIDGAGEKLVSYV--HVSNNYVNAYWDGEKMSYGDGDGRNSGPL-TALDIAGHEIAHGLTERTAGLIYRGESGGL NESYSDLMGYII---SGASNPEIGAD---------TQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQN--- NE+ SD+MG + + NP++ + ++ D G+R + P+K D+ + Y Q VH +SGI N Y + NEAMSDIMGAGLEWYASQKNPDVKFNWTVGETAWTPKNGDPTDGLRYMDDPTK----------DNYSVDNYKNYPKQTEVHGSSGIANNAFYLLTNGGTN ----------LGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIG +G+EK I+Y +L +Y+TP F+ AR A + AA YG ++A V + +G RTSGIEVKDAIGMEKGLKIYYRALAHYMTPSTTFAQARTATINAATDLYGADSAEVAKVKESWTAVG
Show aligned area	42781819	Bacillus cereus ATCC 10987	neutral protease	388	1e-23	0.33	0.51
AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV------DEQHPDAYDNAFW--DGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLG AV A+ V +Y+D + R+S D++G ++SVV + +P + NA +G + YG+ P K Y DV GHE TH VT + LEY G AVSAHYLATKVFDFYKDKYNRNSFDNKGQKVVSVVHAWDSEETNNPKNWQNALSANNGSMLVYGD---PIVKAY----DVAGHEFTHAVTSSESNLEYYG QSGALNESYSDLMG-----YIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI-------- +SGA+NE+ SD+MG Y+ +G+ N +G T SV R+++ P+ + DD + + +DQGGVH+NS IIN++ Y I ESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTGSV-----FRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGGVHFNSSIINKVAYLIAKGGTHNG --IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI ++ +G +K IFY + + L + F + R A + A +YG A V V AF++A I VTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSACIRVATNKYGANTAEVQAVQKAFDAAKI
Show aligned area	162452774	Sorangium cellulosum 'So ce 56'	metalloprotease	580	1e-23	0.32	0.47
AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVD-----EQHPDAYDNAFWDGKAMRYGETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQS A+ A+ + V + +R ID +GM + SVV+ ++ PD + NA W M YG ++YA LDVV HE+THG+TEHT+ L Y QS AISAHVNAGRVYDFCRVVLKRDGIDGKGMTVESVVNCTSLADRSPDEWHNAVWFQNRMWYGRAKDGDRYRSYARYLDVVAHELTHGITEHTSNLVYRDQS GALNESYSDLMGYIISG--ASNPEIGADTQSVDRKTG-------IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTII----- GALNES+SD+ G +I + T S D G +R++ P++ G P M +Y R D+GGVHY S I N+ Y ++ GALNESFSDIFGVLICNYWLAPARDDVSTWSWDIGPGLGKNGKPLRDMSDPARLGYPVHMREYVRMVR-------DEGGVHYYSSIHNKAAYNVLTATDD ---QNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA-----ASVVSAAFNSAGI + E+ ++Y +L L A F A +L K YG+ A + ++ A+ GI TSKRVFSPEEVAVLYYLTL-GRLDRMATFEKALAVLLNVTKTYYGNAAKRERNTTAIARAYADVGI
Show aligned area	108761953	Myxococcus xanthus DK 1622	M4 family peptidase	567	1e-23	0.24	0.40
DAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTG D G+ H++ ++ EG+ V +I+H+D +G + +V G+ S+ + + + P+ K + + ++ +G LF + DEVGLTHVRYDQVREGLRVVGGELIVHVDTSGQIFAVNGSARGAQAP-SSLSRVSPDAAMAAAVNGLPDMKSMGTTQLVYFLDAQGSLFLAYELVREGER D--PVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVK D P V+A G++++ + + A N + + G L GT Q + + D Y H DDAPARDTVYVDAATGSVLD-------------VHPQYHAAQNRRIHSAGNGSNLPGTLRR----------------QEGGAATGDGHIDDNYDHVGTTY TYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGA Y F R S DD G I S V + Y NAFWDG+ + +G+ LDVV HE TH VT++ +GL Y +SGALNES SD+ I RCYSTIFGRDSFDDAGATITSTV--HYGSRYVNAFWDGRQIVFGDGDNFNSGELGRDLDVVSHEFTHAVTQYDSGLVYRNESGALNESLSDIAAAICESW SNPEIGADTQSVDRKT--------GIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIIN-------------RIGYTI-IQNLGIEKAQT + + AD + +R + P++ G RY GT D GGVH+NSGI N R +I + +G+ +A ARGTVDADVWKIGEDIWTPGTSGDALRYMDNPTRDGSSRDFYP----ERYVGTA--DNGGVHWNSGIPNLAFKLLVTGGTHPRSKTSINVSGVGMNRAAQ IFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI FY + Y T + AR + AA +Y + + V A+++ G+ TFYYANQFYFTANTTMAQARALTIQAAADRYPTDTVNAVRDAWSAVGV
Show aligned area	157371836	Serratia proteamaculans 568	peptidase M4 thermolysin	341	1e-23	0.32	0.48
AVD-AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE AVD AY + ++ F+R+S+D++G+P+ V + Y NAFW+G+ M +G+ + ++DVVGHE+ HGVTE AGL Y Q+GALNE AVDEAYDYLGVTYDFFWQAFKRNSLDNQGLPLTGSV--HYGKEYQNAFWNGQQMVFGDGDGEIFNRFTIAIDVVGHELAHGVTESEAGLIYFQQAGALNE SYSDLMGYIISGASNPEI----------GADTQSVDRKTGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTII S SD+ G ++ + G + ++ K G+R++ P K QP M Y D GGVH NSGI NR Y SLSDVFGSLVKQFHLKQTADKADWLIGEGLLAKGINGK-GLRSMSAPGTAYNDPLLGKDPQPADMKDYIQTKE-------DNGGVHLNSGIPNRAFYLAA QNLG---IEKAQTIFYSSLVNYLTPK-AQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIG LG EKA I+Y +L + P+ A F+ + AK ++ + A V A++ G+ TALGGFAWEKAGYIWYDTLCDKTLPQDADFATFARTTVKHAKQRFDSKVADKVQQAWHQVGVA
Show aligned area	186685654	Nostoc punctiforme PCC 73102	peptidase M4, thermolysin	359	2e-23	0.33	0.51
SLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLG S +A+N+ A DA G +YE F R+S+DD+G+ + S V + YDNAFW+G M YG+ + + +S+DV+GHE+THG+T++ AGL+Y G SDIAVNE-AYDA--AGATYDLFYEI-FDRNSVDDKGLRLDSTV--HYGVKYDNAFWNGDQMVYGDGDGEMFQRFTTSIDVIGHELTHGITQYEAGLQYYG QSGALNESYSDLMGYIISGASNPEIGADTQ---------SVDRKTGIRNLQTPSKHGQPETMAQYDDRA----RYKGTPYYDQGGVHYNSGIINRIGYTI + GALNES+SD+ G ++ S + + + +R+++ P M + A +Y GT D GGVH NSGI N Y EPGALNESFSDVFGSLVKQKSKNQTAQEADWLIGEGLLVPTVKGVALRSMKAPGTAYDDPVMGKDPQPAHVKDKYTGTD--DNGGVHINSGIPNHAFYLA IQNLG---IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD--EAASVVSAAFNSAGI ++G EKA I+Y +L + L KA F A + A YG+ + V A+ G+ AVSIGGYAWEKAGKIWYIALRDRLKAKADFKKAASVTIQIAGELYGNGSDDQKAVQDAWQKVGV
Show aligned area	108761920	Myxococcus xanthus DK 1622	matrix-associated zinc metalloprotease FibA	744	5e-23	0.29	0.41
DAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGN-----------PVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLF D G H + + + V +I+H RNG V + N + + +VD+ E +K + NPE LV+ RV++E +L DKQGDSHYRYSVKHNDIPVLGGELILHA-RNGKVFAANTNVRSDLRAELKATIAGEIATSAVDS-DRETLKGWVTDKNPE---LVYW----RVDDELRLM YKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVD YKV V N DGT + L + ++V L+ +P K + LH +NT V + + P +N N YKV-------------VQHGNKADGTPVRDWVLVDARNADVMLR--------IPQIKESLDRRLHNGNNTSTLPGAVVRIEGAAPVADP---VVNTN--- AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSD Y H V Y F R SID+ G ++S V H Y NAFWDG M YG+ T A+SLDV HE+TH VT++ + L Y G+SG LNES SD -YDHLGTVYDCYNTLFGRDSIDNAGGTLISTV--HHRVNYVNAFWDGTQMVYGDGDGVTATNLANSLDVTAHELTHAVTDNESDLIYSGESGGLNESMSD LMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTP------YYDQGGVHYNSGIINRIGY--------------TIIQNL + G + + GAD S ++ TPS P +Y + G Y GVHY+SGI N Y ++ + VFGAVCEWYGD---GADEVSPRHWLIGDDVWTPSI---PNDALRYMNDPALDGDSLDHYHNYVPGTGVHYSSGISNLAFYLLSQGGTHPRGKSTIVVAGI GIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAA GIEKA IFY + + P + F A+ AA Q G +AA++ S + GIEKAAQIFYKA-NTLMVPTSNFEAAKTISEQAA-AQLGYDAATIESVS
Show aligned area	222148137	Agrobacterium vitis S4	extracellular metalloprotease precursor protein	351	7e-23	0.34	0.51
VKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS V+ +Y F+R+SID GM ILS V + Y+NAFW+G M YG+ + S DVVGHE+THG+T++T GL+Y Q G LNES SD+ G + VEQFYSSVFKRNSIDGNGMTILSSV--HYGRDYNNAFWNGSQMAYGDGDGEIFTPFCESADVVGHELTHGITQYTLGLDYENQPGGLNESLSDVFGSMFK GASNPE--------IGADT---QSVDRKTGIRNLQTP-SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIFYSS + + IG D + + T +R++ P + H E ++ + D Y D H +SGI NR Y +G +KA I+Y + QWTKDQNADEADWLIGNDILGPTARQKYTCLRDMANPEASHCMAEQISHFSD--------YRDGMDPHESSGIANRAFYLAATRIGGKSWDKAGQIWYDA LV-NYLTPK---AQFSDARDAMLAAAKVQYGDEA-ASVVSAAFNSAGI L N P A+F+DA A AA++ GD + A V+ A++ G+ LTKNGSNPDMTMAEFADATRA--GAARLYPGDGSLAEVLDTAWSEVGL
Show aligned area	92114655	Chromohalobacter salexigens DSM 3043	peptidase M4, thermolysin	348	7e-23	0.33	0.51
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYII---- +Y + F R SIDDRGMP++ V + YDNAFW+G M +G+ + + ++ +VV HE+THGV E GL Y GQSGALNES +D+ G ++ FYWEVFGRDSIDDRGMPLIGTV--HYGRDYDNAFWNGAQMVFGDGDGDLFRRFTAAPEVVAHELTHGVIERDVGLVYAGQSGALNESLADVFGVVVKQYH SGASNPE----IGADTQSVDRKTG--IRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGY---TIIQNLGIEKAQTI +G + E IGA + DR G +R+++ P + QP M + D D GGVH NSGI NR Y ++ E + AGQTAQEADWLIGAALLT-DRVQGRALRSMEAPGTAYDDPVLGRDPQPGHMRDFVDTQA-------DNGGVHINSGIPNRAFYLAAVALEAPAWESVAPV FYSSLV-NYLTPKAQFSDARDAMLAAAKVQYGD--EAASVVSAAFNSAGI +Y+++ + L+ ++ F+ +A A+ Q+G+ A V A+ G+ WYAAMRDDALSRESDFAAFAALTVAHARRQHGEGSREARAVDDAWREVGV
Show aligned area	67078241	Bacillus cereus E33L	neutral protease	568	9e-23	0.25	0.44
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVD---AIGEEGVKK---IIASDN------ L + ++ + Y V ++ G ++L++ EG V + H++ +G +TSV+G+ + + + + + EE KK I DN LSSKQVNTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSVSGDSAQDLQQQEDLKQPITLSEEDAKKQLFKIYGDNLTFVEE PETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEV---TLKNSFQVAFNVPVEKSNTGIALHGTDNT----- PE K +V+ +D+ N + S+P + VS ++A G ++ ++L + +G +V ++++ P + + TG G + T PEIKQVVY--VDENTNKATSAYQITFSASTP--EYVSGTVLIDAFVGDLL--KELVQKLGIQVDSSIVQSATSNKSQDPSKLTGTGKDDLGMNRTFGISQ -----------------GVYHAVVDGKNNY---------SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV--------DEQH Y A NNY ++ + S + AV A+ V +Y++ + R+S D+ G ++SVV ++ + RSDGTYTLADYSRGKGIETYTANYKDYNNYRRNIWGYLDDLVTSNSTNFTDPKAVSAHYLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGTNKGN PDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPS P + NAF +G + YG+ + DV GHE TH VT + +GLEY G++GA+NE+ SD++G + +N G ++ ++G R+++ PS PKQWFNAFSNGAMLVYGDP-------IVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEAISDILGVAVEKYANN--GKFNWTMGEQSGRIFRDMKNPS KHGQPETMAQY-DDRARYKGTPY---YDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD ++Y +D Y P +D GGVH NS IIN++ Y I +Q +G +K IFY + + L + F + ++A + A YG -----SISSRYPEDYRHYNNLPIDAAHDHGGVHTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIRVATNLYGK EAASV--VSAAFNSAGI +++ V V AF +A I DSSEVQAVQQAFKAAYI
Show aligned area	83643711	Hahella chejuensis KCTC 2396	Zinc metalloprotease (elastase)	764	1e-22	0.32	0.49
NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPD-----AYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLG +++A AY + + +Y++ F R S D RG ++S V + DNA+++G+ M YGE + + A +LD+V HE+THGVT + L Y DEHAKAAYDNSGYTYWFYDNMFNRDSYDGRGKKMVSTVHAMFTTPNGGCSGDNAYFNGEQMIYGEGGSML-QNPAGALDIVAHELTHGVTFSESNLTYRN QSGALNESYSDLMG-----YIISGA---SNPEIGADTQSVDRKTG---------IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRI +SGA+NE+ SD+ G Y++SG S P G Q + G +R++ P GQ + YD +RY GT D GGVH NSGI+N ESGAINEALSDIFGAGAETYVMSGGSANSKPSGGLKPQRSNWTLGEKASPNGSMMRDMSDPVADGQ--SRDSYD--SRYTGTQ--DNGGVHLNSGIMNLA GYTI--------------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD Y + + +G+EKA I+Y + N T F+ AR + +A+ YG+ FYLLSEGGVHPRGKTTNRVTGIGMEKALEIYYHANTNLFTASTNFASARTRLAQSAETLYGE
Show aligned area	182438804	Streptomyces griseus subsp. griseus NBRC 13350	putative metalloprotease	358	1e-22	0.33	0.50
FQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIG + R SID +G+P++ V + + Y+NAF+DG+ M +G+ + ++DV+ HE+ HG+T+HTA L Y GQSGALNES SD+ G ++ S +G YGRSSIDGKGLPLIGSV--HYGEEYNNAFFDGEQMVFGDGDGEIFLDFTVAVDVIAHELAHGLTQHTANLRYEGQSGALNESVSDVFGALVKQFS---LG ADTQSVDRKTG------------IRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIFYS + D G +R+++ P K QP +M Y + D GGVH NSGI NR Y + LG E+A I++ QSAEQADWLIGAGLLAPRVSGDALRSMKAPGTAYDDDVLGKDPQPASMDDYIETEE-------DNGGVHLNSGIPNRAFYLLATALGGNSWERAGQIWFD SLV-NYLTPKAQFSDARDAMLAAAKVQYG--DEAASVVSA L LT A F+ +AAA ++G DE +V+ A VLTGGELTANADFAQFARLTVAAAGDRFGAADEREAVLKA
Show aligned area	30021487	Bacillus cereus ATCC 14579	bacillolysin	565	2e-22	0.24	0.44
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVD---AIGEEGVKKIIAS---------DN L + ++ + Y V ++ G ++L++ EG V + H++ +G +TSV+G+ + + + + + EE KK + + + LSSKQVNTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSVSGDSAQDLQQQEDLKQPITLSEEDAKKQLFNIYGNDLTFIEE PETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGT--DNTGV---- PE K +V+ +D+ N + S+P + VS ++A G ++ ++L + +G +V + + V KS L GT D+ G+ PEIKQVVY--VDENTNKATNAYQITFSASTP--EYVSGTVLIDAFGGNLL--KELVQKLGIQV----DSSIVQSATVNKSQDPSKLTGTGKDDLGINRTF -----------------------YHAVVDGKNNY---------SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV-------- Y A NNY ++ + S + AV A+ V +Y++ + R+S D+ G ++SVV GITQRSDGTYMLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAHYLATKVYDFYQEKYGRNSFDNNGQKVISVVHGWNTNGT DEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNL ++ +P + NAF +G + YG+ + DV GHE TH VT + +GLEY G++GA+NE+ SD++G + +N G ++ ++G R++ NKGNPKQWFNAFSNGAMLVYGDP-------IVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDILGVAVEKYANN--GKFNWTMGEQSGRIFRDM QTPSKHGQPETMAQY-DDRARYKGTPY---YDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKV + PS ++Y +D Y P +D GGVH NS IIN++ Y I + +G +K IFY + + L + F + ++A + A KNPS-----SISSRYPEDYRHYNNLPIDADHDHGGVHTNSSIINKVAYLIASGGNHNGVNVHGIGEDKMFDIFYYANTDELNMTSDFKELKEACIHVATN QYGDEAASV--VSAAFNSAGI YG ++ V V AF +A I LYGKDSLEVQAVQQAFKAAYI
Show aligned area	37676197	Vibrio vulnificus YJ016	Zinc metalloprotease	608	3e-22	0.35	0.51
VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESY VDA+ +Y+ Q + ++ ++S + Y+NA+W+G M YG+ + + LDVVGHE++HG+T+ T+ L Y +SGALNE++ VDAHFFANVTDSYFLSVLQFNWLNHYSQGMVSTAHVKR--NYNNAYWNGYQMAYGDGDGISFINLSGDLDVVGHELSHGLTDATSDLIYQNESGALNEAF SDLMGYIIS---GASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTII---QN------------- SD+MG I G+ N IG D GIRN+ P + G P + Y++ RY GT D GGVH NSGIIN Y ++ QN SDIMGTNIEFYYGSGNWTIGEDITP--NSNGIRNMADPGEDGDP---SHYNE--RYTGTG--DNGGVHINSGIINHWYYLLVNGGQNSDGQFASGTDVAG LGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSA +G++ A I Y+ + L P A F AR A A A G +A+V+ A IGLDAATQIVYNGFTS-LPPNADFCLARAATDAVA----GTHSANVLDA
Show aligned area	108763220	Myxococcus xanthus DK 1622	M4 family peptidase	384	3e-22	0.32	0.50
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYII---- ++ + F R SID GMP+ + V + + YDNAFWDG+ M +G+ + LD++ HE+ HGVTE L Y Q+GALNES SD+ G ++ FFWEIFGRSSIDGDGMPLQAFV--HYGNTYDNAFWDGRRMVFGDGDGDLFNRFTICLDIIAHELAHGVTEDEGPLWYFRQAGALNESMSDVFGSLVRQMK ----SGASNPEIGAD--TQSVDRKTGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTI + A++ IG + T +V+ +R+++ P K QP M Y + D GG H NSGI NR Y + +LG E+A I LKQKADAADWLIGKELLTGNVE-GVALRSMKNPGTAFDDDVLGKDPQPGHMKDYVH-------TWEDNGGGHINSGIPNRAFYLVASHLGGYAWERAGRI FYSSLVN-YLTPKAQFSD-ARDAMLAAAKVQYGDEAASVVSAAFNSAGI +Y ++ + ++ P F D AR +++A ++ E V A+ GI WYDAIRDSHIKPDMGFLDFARITVMSATRLFGAGEEEDAVREAWEQVGI
Show aligned area	146298648	Flavobacterium johnsoniae UW101	peptidase M4, thermolysin	924	3e-22	0.27	0.44
DNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAV D K L + A K +N+ + +V+SS + D + +++ TI+ T + G++ ++ + +GI + + T Y DAQTGKALFYNAAIKHLNDN---VHARKVSSSKSADKET----ASSSKKTIVAANAETRYSGTQTIQTTLSGSSYILLDGTRGSGIQTYNSARTATYPTT --VDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDA----YDNAFWDGKAMRYGETSTPTGKTYASSLDVV D NN++ + + + A+DA+ + Y+ R+S DD G I S V A +NAFW+G M YG+ S G +SLDV NFTDADNNWTAAEYNN-TNKDNGALDAHWGAEMTYDYWSAVHGRNSYDDAGAKIKSYVHYNLIAAGYSSNNNAFWNGSVMTYGDGSGTGGFDILTSLDVA GHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPE-----IGADTQSVDRKTGIRNLQTPSKHGQPETMAQYD-DRARYKGTPYYDQGGVHY GHE+ H V +TA L Y +SGA+NE++SD+ I + P +G D + +R++ P GQP+T + T D GVH GHEIGHAVCTYTANLAYQKESGAMNEAFSDIWAACIEYRAAPTKSTWLVGEDIERRSGHVALRSMSNPKSEGQPDTYGGTNWISVSCTPTSSNDYCGVHT NSGIINRIGYTI---------------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSA--AFNSAGIGA NSG+ N Y + + +GI+KA I + YLT + F++AR + + +A YG +A V++ AF + G+GA NSGVFNHWFYILSVGKTGTNDIGSSYNVTGIGIDKAAKIAFRLEDVYLTSNSTFANARTSGIQSAIDLYGAGSAEVIATTNAFYAIGVGA
Show aligned area	218231055	Bacillus cereus B4264	bacillolysin	565	4e-22	0.24	0.44
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVD---AIGEEGVKKIIAS---------DN L + ++ + Y V ++ G ++L++ EG V + H++ +G +TSV+G+ + + + + + EE KK + + + LSSKQVNTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSVSGDSAQNLQQQEDLKQPITLSEEDAKKQLFNIYGNDLTFIEE PETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEK--QDLTEHVGSEV-----------------TLKNSFQVAFNVPVEKSN PE K +V+ +D+ N + S+P + VS ++A G ++++ Q L V S + T K+ + + + + PEIKQVVY--VDENTNKATNAYQITFSASTP--EYVSGTVLIDAFGGNLLKELVQKLGIQVESSIVQSATSNKSTDPSKLTGTGKDDLGINRTFGITQRS TGIALHGTDNTG----VYHAVVDGKNNY---------SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV--------DEQHPD G + + G Y A NNY ++ + S + AV A+ V +Y++ + R+S D+ G ++SVV ++ +P DGTYMLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAHYLATKVYDFYQEKYGRNSFDNNGQKVISVVHGWNTNGTNKGNPK AYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNLQTPSKH + NAF +G + YG+ + DV GHE TH VT + +GLEY G++GA+NE+ SD++G + +N G ++ ++G R+++ PS QWFNAFSNGAMLVYGDP-------IVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDILGVAVEKYANN--GKFNWTMGEQSGRIFRDMKNPS-- GQPETMAQY-DDRARYKGTPY---YDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA ++Y +D Y P +D GGVH NS IIN++ Y I + +G +K IFY + + L + F + ++A + A YG ++ ---SISSRYPEDYRHYNNLPIDADHDHGGVHTNSSIINKVAYLIASGGSHNGVNVHGIGEDKMFDIFYYANTDELNMTSDFKELKEACIRVATNLYGKDS ASV--VSAAFNSAGI V V AF +A I LEVQAVQQAFKAAYI
Show aligned area	52142150	Bacillus cereus E33L	neutral protease (bacillolysin)	565	4e-22	0.25	0.44
LEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVD---AIGEEGVKK---IIASDN------ L + I+ + Y V ++ G ++L++ EG V + H++ +G +TSV+G+ + + + + + EE KK I DN LSSKQINTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSVSGDSAQDLQQQEDLKQPITLSEEDAKKQLFKIYGDNLTFVEE PETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGT--DNTGV---- PE K +V+ +D+ N + S+P + VS ++A G ++ ++L + +G +V + + KS L GT D+ G+ PEIKQVVY--VDENTNKATNAYQITFSASTP--EYVSGTVLIDAFVGDLL--KELVQKLGIQV----DSSIVQSATANKSQDPSKLTGTGKDDLGINRTF -----------------------YHAVVDGKNNY---------SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV-------- Y A NNY ++ + S + AV A+ V +Y++ + R+S D+ G ++SVV GITQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAHYLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGK DEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTG--IRNL + +P + NAF +G + YG+ + DV GHE TH VT + +GLEY G++GA+NE+ SD++G + +N G ++ ++G R++ NIGNPKQWFNAFSNGAMLVYGDP-------IVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDILGVAVEKYANN--GKFNWTMGEQSGRIFRDM QTPSKHGQPETMAQY-DDRARYKGTPY---YDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKV + PS ++Y +D Y P +D GGVH NS IIN++ Y I +Q +G +K IFY + + L + F + ++A + A KNPS-----SISSRYPEDYRHYNNLPIDADHDYGGVHTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIRVATN QYGDEAASV--VSAAFNSAGI YG ++ V V AF +A I LYGKDSLEVQAVQQAFKAAYI
Show aligned area	49478205	Bacillus thuringiensis serovar konkukian str. 97-27	neutral protease (bacillolysin)	565	6e-22	0.25	0.44
FSSLFVAAEEQVYSESEVSTVLSKLEKEAISEAAAE-----QYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQS F + + A Q +E+ V L ++A+S Y V ++ G ++L++ EG V + H++ +G +TS++G+ + + + FRTGNLTAPSQKSAENVVKDALKGKTEQALSSKQVNTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSISGDSAQDLQQQED VD---AIGEEGVKK---IIASDN------PETKDLVFLAIDKRVNNEGQLFYKVRVTSSP------------TGDPV-SLVYKVN-ATDGTIMEK----- + + EE KK I DN PE K +V+ +D+ N + S+P GD + LV K+ D +I++ LKQPITLSEEDAKKQLFKIYGDNLTFVEEPEIKQVVY--VDENTNKATNAYQITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGIQVDSSIVQSATANK -QDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTG----VYHAVVDGKNNY---------SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHF QD ++ +G T K+ + + + + G + G Y A NNY ++ + S + AV A+ V +Y++ + SQDPSKLIG---TGKDDLGMNRTFGISQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAHYLATKVYDFYQEKY QRHSIDDRGMPILSVV--------DEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISG R+S D+ G ++SVV + +P + NAF +G + YG+ + DV GHE TH VT + +GLEY G++GA+NE+ SD++G + SRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDP-------IVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDILGVAVEK ASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQY-DDRARYKGTPY---YDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSS +N G ++ ++G R+++ PS ++Y +D Y P +D GGVH NS IIN++ Y I +Q +G +K IFY + YANN--GKFNWTMGEQSGRIFRDMKNPS-----SISSRYPEDYRHYNNLPIDADHDYGGVHTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYA LVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI + L + F + ++A + A YG +++ V V AF +A I NTDELNMTSDFKELKEACIRVATNLYGKDSSEVQAVQQAFKAAYI
Show aligned area	218904524	Bacillus cereus AH820	bacillolysin	565	6e-22	0.25	0.44
FSSLFVAAEEQVYSESEVSTVLSKLEKEAISEAAAE-----QYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQS F + + A Q +E+ V L ++A+S Y V ++ G ++L++ EG V + H++ +G +TS++G+ + + + FRTGNLTAPSQKSAENVVKDALKGKTEQALSSKQVNTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSISGDSAQDLQQQED VDA---IGEEGVKK---IIASDN------PETKDLVFLAIDKRVNNEGQLFYKVRVTSSP------------TGDPV-SLVYKVNA-TDGTIMEK----- + + EE KK I DN PE K +V+ +D+ N + S+P GD + LV K+ D +I++ LKQPIILSEEDAKKQLFKIYGDNLTFVEEPEIKQVVY--VDENTNKATNAYEITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGVQVDSSIVQSATANK -QDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTG----VYHAVVDGKNNY---------SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHF QD ++ +G T K+ + + + + G + G Y A NNY ++ + S + AV A+ V +Y++ + SQDPSKLIG---TGKDDLGMNRTFGISQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAHYLATKVYDFYQEKY QRHSIDDRGMPILSVV--------DEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISG R+S D+ G ++SVV + +P + NAF +G + YG+ + DV GHE TH VT + +GLEY G++GA+NE+ SD++G + SRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDP-------IVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDILGVAVEK ASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQY-DDRARYKGTPY---YDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSS +N G ++ ++G R+++ PS ++Y +D Y P +D GGVH NS IIN++ Y I +Q +G +K IFY + YANN--GKFNWTMGEQSGRIFRDMKNPS-----SISSRYPEDYRHYNNLPIDADHDYGGVHTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYA LVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI + L + F + ++A + A YG +++ V V AF +A I NTDELNMTSDFKELKEACIRVATNLYGKDSSEVQAVQQAFKAAYI
Show aligned area	50122133	Pectobacterium atrosepticum SCRI1043	extracellular metalloprotease	347	6e-22	0.30	0.45
AVD-AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE AVD AY + ++ FQR+S+D G+ + V + Y NAFW G+ M +G+ + +LDV+ HE+ HG+TEH AGL Y QSGALNE AVDEAYDYLGVTYDFFWKVFQRNSLDAEGLTLAGTV--HYGQDYQNAFWTGQQMVFGDGDGKIFNRFTIALDVIAHELAHGITEHEAGLIYFRQSGALNE SYSDLMGYIISGASNPEIGADTQSVD------------RKTGIRNLQTPSK---------HGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYT S SD+ G ++ +G + D G+R++ P QP M +Y + D GGVH NSGI NR Y SLSDVFGSMV---KQYHLGQTAEQADWFIGAELLADGIHGMGLRSMSHPGTAYDDELLGIDPQPSHMNEYVNTRE-------DNGGVHLNSGIPNRAFYL IIQNLG---IEKAQTIFYSSLVNYLTPK-AQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKED LG EKA I+Y +L + P+ A F + A ++ A +V ++ + G+ +++ TAIALGGHSWEKAGRIWYDTLCDKTLPQNADFEIFARHTIQHAAQRFNQTVADIVQQSWETVGVEVRKE
Show aligned area	27366494	Vibrio vulnificus CMCP6	Zinc metalloprotease	595	8e-22	0.34	0.50
VDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESY VDA+ +Y+ Q + ++ ++S + Y+NA+W+G M YG+ + + LDVVGHE++HG+T+ T+ L Y +SGALNE++ VDAHFFANVTDSYFLSVLQFNWLNHYSQGMVSTAHVKR--NYNNAYWNGYQMAYGDGDGISFINLSGDLDVVGHELSHGLTDATSDLIYQNESGALNEAF SDLMGYIIS---GASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTII---QN------------- SD+MG I G+ N IG D GIRN+ P + G P + Y++ RY GT D GGVH NSGIIN Y ++ QN SDIMGTNIEFYYGSGNWTIGEDITP--NSNGIRNMADPGEDGDP---SHYNE--RYTGTG--DNGGVHINSGIINHWYYLLVNGGQNSDGQFASGTDVAG LGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQ +G++ A I Y+ + L P A F AR A A A IGLDAATQIVYNGFTS-LPPNADFCLARAATDAVASTH
Show aligned area	49186194	Bacillus anthracis str. Sterne	neutral protease	565	1e-21	0.25	0.43
FSSLFVAAEEQVYSESEVSTVLSKLEKEAISEAAAE-----QYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQS F + + A Q +E+ V L ++A+S Y V ++ G ++L++ EG V + H++ +G +TS++G+ + + + FRTGNLTAPSQKSAENVVKDALKGKTEQALSSKQVNTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSISGDSAQDLQQQED VDA---IGEEGVKK---IIASDN------PETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEK--QDLTEHVGSEVTLKNSF + + EE KK I DN PE K +V+ +D+ N + S+P + VS ++A G ++++ Q L V S + + LKQPIILSEEDAKKQLFKIYGDNLTFVEEPEIKQVVY--VDENTNKATNAYQITFSASTP--EYVSGTVLIDAFVGDLLKELVQKLGIQVDSSIVQSATA QVAFNVPVEKSNTGIALHGTDNT----------------------GVYHAVVDGKNNY---------SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHF + + P + + TG G + T Y A NNY ++ + S + AV A+ V +Y++ + NKSQD-PSKLTGTGKDDLGMNRTFGITQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAHYLATKVYDFYKEKY QRHSIDDRGMPILSVV--------DEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISG R+S D+ G ++SVV + +P + NAF +G + YG+ + DV GHE TH VT + +GLEY G++GA+NE+ SD++G + SRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDP-------IVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDILGVAVEK ASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQY-DDRARYKGTPY---YDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSS +N G ++ ++G R+++ PS ++Y +D Y P +D GGVH NS IIN++ Y I +Q +G +K IFY + YANN--GKFNWTMGEQSGRIFRDMKNPS-----SISSRYPEDYRHYNNLPIDADHDYGGVHTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYA LVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI + L + F + ++A + A YG ++ V V AF +A I NTDELNMTSDFKELKEACIRVAMNLYGKDSLEVQAVQQAFKAAYI
Show aligned area	47528726	Bacillus anthracis str. 'Ames Ancestor'	neutral protease	565	1e-21	0.25	0.43
FSSLFVAAEEQVYSESEVSTVLSKLEKEAISEAAAE-----QYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQS F + + A Q +E+ V L ++A+S Y V ++ G ++L++ EG V + H++ +G +TS++G+ + + + FRTGNLTAPSQKSAENVVKDALKGKTEQALSSKQVNTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSISGDSAQDLQQQED VDA---IGEEGVKK---IIASDN------PETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEK--QDLTEHVGSEVTLKNSF + + EE KK I DN PE K +V+ +D+ N + S+P + VS ++A G ++++ Q L V S + + LKQPIILSEEDAKKQLFKIYGDNLTFVEEPEIKQVVY--VDENTNKATNAYQITFSASTP--EYVSGTVLIDAFVGDLLKELVQKLGIQVDSSIVQSATA QVAFNVPVEKSNTGIALHGTDNT----------------------GVYHAVVDGKNNY---------SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHF + + P + + TG G + T Y A NNY ++ + S + AV A+ V +Y++ + NKSQD-PSKLTGTGKDDLGMNRTFGITQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAHYLATKVYDFYKEKY QRHSIDDRGMPILSVV--------DEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISG R+S D+ G ++SVV + +P + NAF +G + YG+ + DV GHE TH VT + +GLEY G++GA+NE+ SD++G + SRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDP-------IVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDILGVAVEK ASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQY-DDRARYKGTPY---YDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSS +N G ++ ++G R+++ PS ++Y +D Y P +D GGVH NS IIN++ Y I +Q +G +K IFY + YANN--GKFNWTMGEQSGRIFRDMKNPS-----SISSRYPEDYRHYNNLPIDADHDYGGVHTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYA LVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI + L + F + ++A + A YG ++ V V AF +A I NTDELNMTSDFKELKEACIRVAMNLYGKDSLEVQAVQQAFKAAYI
Show aligned area	30263348	Bacillus anthracis str. Ames	neutral protease	565	1e-21	0.25	0.43
FSSLFVAAEEQVYSESEVSTVLSKLEKEAISEAAAE-----QYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQS F + + A Q +E+ V L ++A+S Y V ++ G ++L++ EG V + H++ +G +TS++G+ + + + FRTGNLTAPSQKSAENVVKDALKGKTEQALSSKQVNTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSISGDSAQDLQQQED VDA---IGEEGVKK---IIASDN------PETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEK--QDLTEHVGSEVTLKNSF + + EE KK I DN PE K +V+ +D+ N + S+P + VS ++A G ++++ Q L V S + + LKQPIILSEEDAKKQLFKIYGDNLTFVEEPEIKQVVY--VDENTNKATNAYQITFSASTP--EYVSGTVLIDAFVGDLLKELVQKLGIQVDSSIVQSATA QVAFNVPVEKSNTGIALHGTDNT----------------------GVYHAVVDGKNNY---------SIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHF + + P + + TG G + T Y A NNY ++ + S + AV A+ V +Y++ + NKSQD-PSKLTGTGKDDLGMNRTFGITQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAHYLATKVYDFYKEKY QRHSIDDRGMPILSVV--------DEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISG R+S D+ G ++SVV + +P + NAF +G + YG+ + DV GHE TH VT + +GLEY G++GA+NE+ SD++G + SRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDP-------IVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDILGVAVEK ASNPEIGADTQSVDRKTG--IRNLQTPSKHGQPETMAQY-DDRARYKGTPY---YDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSS +N G ++ ++G R+++ PS ++Y +D Y P +D GGVH NS IIN++ Y I +Q +G +K IFY + YANN--GKFNWTMGEQSGRIFRDMKNPS-----SISSRYPEDYRHYNNLPIDADHDYGGVHTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYA LVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGI + L + F + ++A + A YG ++ V V AF +A I NTDELNMTSDFKELKEACIRVAMNLYGKDSLEVQAVQQAFKAAYI
Show aligned area	188574314	Xanthomonas oryzae pv. oryzae PXO99A	neutral protease A	207	1e-21	0.38	0.51
FQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPE-- + R+SID +GMP++ V + D DNAFW+G+ M +G+ + ++DVVGHE+THGVTE T L Y QSGA NE+ SD+ G +I + + YGRNSIDAKGMPLIGSVHYERGD--DNAFWNGEQMVFGDGDGEVFNRFTIAIDVVGHELTHGVTERTTNLIYQRQSGASNEAVSDVFGLLIKQYTLRQSA ------IGADTQSVDRK-TGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIFYSSL IGA K G+R++Q P K QP TM Y D + D GGVHYNSGI N Y +G EKA I+Y +L EQADWIIGAGLLMPGIKGVGLRSMQAPGSASDDPARGKDPQPATMTGYVDTHK-------DDGGVHYNSGIPNHAFYRAAVAIGGAAWEKAGRIWYRAL
Show aligned area	119962526	Arthrobacter aurescens TC1	putative thermolysin metallopeptidase	368	1e-21	0.33	0.48
YEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASN Y + F R SIDD G+ + + V + YDNAFWDG M +G+ + + S+ V+GHE+ HGVT++TA L Y Q+GALNES SD+ G ++ YGEIFGRDSIDDAGLSLDATV--HYGKLYDNAFWDGSQMVFGDGDGQIFQRFTKSVSVIGHELAHGVTQYTANLAYRNQAGALNESMSDVFGVLVEQYLK PEIGAD----------TQSVDRKTGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIF E D T+ V + +R+++ P K QP++M Y + D GGVH NSGI N+ Y + LG E I+ QESAGDASWLIGEGLFTEQV-QGAALRSMKAPGTAYDDDVLGKDPQPDSMDTYVRTSA-------DNGGVHINSGIPNKAFYVVASELGGKAWEAPGQIW YSSLVNYLTPKA-QFSDARDAMLAAAKVQYGDEAA Y +L + P F LA A+ +G +A YGTLTSGSLPATCTFGKFAKTTLATAEELFGSGSA
Show aligned area	116671175	Arthrobacter sp. FB24	peptidase M4, thermolysin	347	2e-21	0.33	0.49
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE +A +AY Y + F R+SID +G+ + + V YDNAFWDG M +G+ + + SL V+GHE+ HGVT+H+AGL Y Q+GA+NE SADEAYDGLGHTHRLYAEAFGRNSIDGQGLALDASV--HFGKLYDNAFWDGHQMVFGDGDGEIFQRFTRSLSVIGHELAHGVTQHSAGLVYRNQAGAINE SYSDLMGYII-------SGASNPEIGADTQSVDRKTG--IRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ S SD+ G ++ S + + + D+ G +R+L+ P K QP++M Y + D GGVH NSGI NR Y + SLSDVFGALVEQYLAQQSASEASWLIGENLFTDKVQGSALRSLKAPGTAYDDDVLGKDPQPDSMDSYVRTSA-------DNGGVHINSGIPNRAFYLVAS NLGIEKAQT---IFYSSLVNYLTP LG +T I+Y +L P ALGGNAWETPGRIWYDALTGGSLP
Show aligned area	20091357	Methanosarcina acetivorans C2A	extracellular protease	380	2e-21	0.33	0.49
EDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNP E R+S+D+ GM ++ V Y+NAFWDG+ + G+ ++ SLDV+ HE+ HGV + TA EY GQSGALNE ++D+ G +I+ EKVINRNSLDNNGMDLICNV--HFGVKYNNAFWDGEQITLGDGDGIIFTNFSKSLDVIAHELGHGVVQFTADFEYHGQSGALNEHFADVFGTVITQWVEN EIG--ADTQSVDRKTG-------IRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLV + AD D G +R++ P K QP M Y GT D GGVH NSGI+N+ Y +G ++A I+Y++L QTSDKADWLIGDEIMGPELYGEALRSMSEPGTAYDNSILGKDPQPAHMKDI-----YTGTG--DNGGVHINSGIMNKAFYLTAIEIGTDQAALIWYNALQ NYLTPKAQFSDARDAMLAAAKV-----QYGDEAASVVSAAFNSAGI N L P A F +A ++ AA++ + +A V AF G+ N-LWPTAIFKEAVGEIVKAARILAKNNKVDKDATQRVRTAFREVGL
Show aligned area	146282169	Pseudomonas stutzeri A1501	thermolysin metallopeptidase, putative	347	4e-21	0.32	0.46
AVD-AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE AVD AY T++ FQR SIDD GMP++ V + Y+NAFW+G+ M +G+ + + SLDVV HE+ HG+ E A L Y Q GALNE AVDEAYDALGATYTFFWQVFQRDSIDDLGMPLIGTV--HYGQGYENAFWNGEQMVFGDGDGELFQRFTRSLDVVAHELAHGLIESEAALVYYNQPGALNE SYSDLMGYIIS----GASNPE----IGADTQSVDRKTGI--RNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTII S SD+ G + G + E +GA+ + D+ G+ R++ P + QP M + + D GGVH NSGI NR + SVSDVFGVLTKQHALGQTAAEADWLVGAELLT-DKVQGVALRSMANPGTAYDDPLLGRDPQPAHMRDFIETRE-------DNGGVHLNSGIPNRAFHLAA QNLG---IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQY-------GDEAASVVSAAFNSAGIGAK LG E+ I+Y+++ + P +DA A A +Q G A V A+ G+ + MALGGYAWEQVGRIWYATICDPQLP----NDADFATFAGVTLQQATRLFGRGSSEAEAVQQAWLQVGVSPR
Show aligned area	156932949	Enterobacter sakazakii ATCC BAA-894	hypothetical protein ESA_00752	341	1e-20	0.30	0.47
AVD-AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE AVD AY + ++ ++R S+D++G+ + V + Y NAFW+G+ M +G+ + ++DVVGHE++HGVTE AGL Y Q+GALNE AVDEAYDYLGVTHDFFWKAYKRDSLDNKGLVLNGTV--HYGQEYQNAFWNGQQMVFGDGDGEIFNRFTIAIDVVGHELSHGVTETEAGLIYFEQAGALNE SYSDLMGYIISGASNPEI----------GADTQSVDRKTGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGY--- S SD+ G ++ + G + ++ K G+R++ P K QP M Y D GGVH NSGI NR Y SLSDVFGSLVKQYQRQQTADQADWIIGEGLLAEGINGK-GLRSMSEPGTAYDDPLLGKDPQPGHMKDYVKTRE-------DNGGVHINSGIPNRAFYLAA TIIQNLGIEKAQTIFYSSLVN-YLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI T I EKA +Y ++ + L+ A F+ + + + GD A + A+ + G+ TAIDGYAWEKAGYAWYDTVCDRSLSQNADFASFAKLTIEHGRKRSGDSVAQAIEQAWKTTGV
Show aligned area	84621784	Xanthomonas oryzae pv. oryzae MAFF 311018	putative metalloprotease	207	1e-20	0.38	0.51
FQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYII--------S + R+SID + MP++ V + D DNAFW+G+ M +G+ + ++DVVGHE+THGVTE T L Y QSGA NE+ SD+ G +I + YGRNSIDAKRMPLIGSVHYERGD--DNAFWNGEQMVFGDGDGEVFNRFTIAIDVVGHELTHGVTERTTNLIYQRQSGASNEAVSDVFGLLIKQYTLRHSA GASNPEIGADTQSVDRK-TGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTIFYSSL ++ IGA K G+R++Q P K QP TM Y D + D GGVHYNSGI N Y +G EKA I+Y +L EQADWIIGAGLLMPGIKGVGLRSMQAPGSASDDPARGKDPQPATMTGYVDTHK-------DDGGVHYNSGIPNHAFYRAAVAIGGAAWEKAGRIWYRAL
Show aligned area	222526756	Chloroflexus sp. Y-400-fl	Bacillolysin	1774	1e-20	0.34	0.49
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE + V A+T+ Y+ F R S + G +++VV NAFW+G YG ++ DVV HE TH VT++TAGL Y GQSGALNE DCVAAFTNTGLTYNYFWSTFARDSYNGSGATMIAVV---RYGTAANAFWNGSLTAYGPG--------FATRDVVAHEWTHAVTQYTAGLIYNGQSGALNE SYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQ S+SD+ G ++ + + +G DT IR+L P + QP+ ++ Y D GGVH NSGI N+ Y + I +G SFSDVFGAMVD-SDDWLMGEDTPI----GVIRSLANPPAYNQPDRVSNY-------VCTTSDNGGVHINSGIPNKAAYLMAEGGTFNGRTITAIGRLATA TIFYSSLVNYLTPKAQFSDARDAML IFY +L YLT + F+D +A+L RIFYRALTGYLTSASTFTDLYNALL
Show aligned area	163848803	Chloroflexus aurantiacus J-10-fl	bacillolysin	1774	1e-20	0.34	0.49
NAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE + V A+T+ Y+ F R S + G +++VV NAFW+G YG ++ DVV HE TH VT++TAGL Y GQSGALNE DCVAAFTNTGLTYNYFWSTFARDSYNGSGATMIAVV---RYGTAANAFWNGSLTAYGPG--------FATRDVVAHEWTHAVTQYTAGLIYNGQSGALNE SYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI----------IQNLGIEKAQ S+SD+ G ++ + + +G DT IR+L P + QP+ ++ Y D GGVH NSGI N+ Y + I +G SFSDVFGAMVD-SDDWLMGEDTPI----GVIRSLANPPAYNQPDRVSNY-------VCTTSDNGGVHINSGIPNKAAYLMAEGGTFNGRTITAIGRLATA TIFYSSLVNYLTPKAQFSDARDAML IFY +L YLT + F+D +A+L RIFYRALTGYLTSASTFTDLYNALL
Show aligned area	33597460	Bordetella parapertussis 12822	putative metalloprotease	345	4e-20	0.32	0.47
VALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQS VA+N+ AY H + + RHS+D G +++ V + + YDNAFW+G M +G+ + ++D+V HE+THGV +H GL Y GQS VAVNE----AYDHLGATYALFWQAYGRHSLDGAGRALVASV--HYGEEYDNAFWNGAQMVFGDGDGDVFNRFTIAVDIVAHELTHGVIDHEGGLRYEGQS GALNESYSDLMGYI----ISGASNPE----IGADTQSVD-RKTGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIG GALNES D+ G + ++G + IGA + R +R++ P + QP M + D GGVH NSGI NR GALNESLCDVFGSLAKQHVAGQRADQADWLIGAGLFTAKVRARALRSMAQPGSAYDDPLLGRDPQPGHMRDFVQTGE-------DNGGVHINSGIPNRAF YTIIQNLG---IEKAQTIFYSSL-VNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI + LG E A I+Y +L + LTP+A F A A L+ + A + V A+ G+ HLAATALGGHAWEVAGRIWYDTLRLPALTPQADF--ALFARLSVEQAGRHGAAQAAVRQAWTDVGV
Show aligned area	33601854	Bordetella bronchiseptica RB50	putative metalloprotease	345	4e-20	0.32	0.47
VALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQS VA+N+ AY H + + RHS+D G +++ V + + YDNAFW+G M +G+ + ++D+V HE+THGV +H GL Y GQS VAVNE----AYDHLGATYALFWQAYGRHSLDGAGRALVASV--HYGEEYDNAFWNGAQMVFGDGDGDVFNRFTIAVDIVAHELTHGVIDHEGGLRYEGQS GALNESYSDLMGYI----ISGASNPE----IGADTQSVD-RKTGIRNLQTP---------SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIG GALNES D+ G + ++G + IGA + R +R++ P + QP M + D GGVH NSGI NR GALNESLCDVFGSLAKQHVAGQRADQADWLIGAGLFTAKVRARALRSMAQPGSAYDDPLLGRDPQPGHMRDFVQTGE-------DNGGVHINSGIPNRAF YTIIQNLG---IEKAQTIFYSSL-VNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI + LG E A I+Y +L + LTP+A F A A L+ + A + V A+ G+ HLAATALGGHAWEVAGRIWYDTLRLPALTPQADF--ALFARLSVEQAGRHGAAQAAVRQAWTDVGV
Show aligned area	52840712	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	zinc metalloprotease	543	4e-20	0.33	0.50
DAYTHGKFVKTYYEDHFQRHSIDDR-GMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESY DA G +K Y D + ++ G P+ V+ + Y+NA+WDGK M +G+ T SL V GHE++HG TE +GLEY GQSG +NES+ DALYAGYVIKHMYHDWYGVEALTKSDGSPMQLVMRVHYGQGYENAYWDGKQMTFGDGDTMMYPLV--SLGVGGHEISHGFTEQHSGLEYFGQSGGMNESF SDLMG----YIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ--NLGIEKAQTIFYS SD+ Y G ++ +IG + D +R + PS+ G +A DD YY VHY+SG+ N + Y + N + A + SDMAAQAAEYYSVGKNSWQIGPEIMKEDSGYDALRYMDKPSRDGMSIDVA--DD--------YYGGLDVHYSSGVYNHLFYILANQPNWNLRMAFDVMVK SLVNYLTPKAQFSDARDAMLAAAK + ++Y TP + F + ML+AAK ANMDYWTPYSTFDEGGCGMLSAAK
Show aligned area	54293459	Legionella pneumophila str. Lens	zinc metalloproteinase precursor	543	5e-20	0.33	0.50
DAYTHGKFVKTYYEDHFQRHSIDDR-GMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESY DA G +K Y D + ++ G P+ V+ + Y+NA+WDGK M +G+ T SL V GHE++HG TE +GLEY GQSG +NES+ DALYAGYVIKHMYHDWYGVEALTKSDGSPMQLVMRVHYGQGYENAYWDGKQMTFGDGDTMMYPLV--SLGVGGHEVSHGFTEQHSGLEYFGQSGGMNESF SDLMG----YIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ--NLGIEKAQTIFYS SD+ Y G ++ +IG + D +R + PS+ G +A DD YY VHY+SG+ N + Y + N + A + SDMAAQAAEYYSVGKNSWQIGPEIMKEDSGYDALRYMDKPSRDGMSIDVA--DD--------YYGGLDVHYSSGVYNHLFYILANQPNWNLRMAFDVMVK SLVNYLTPKAQFSDARDAMLAAAK + ++Y TP + F + ML+AAK ANMDYWTPYSTFDEGGCGMLSAAK
Show aligned area	54296501	Legionella pneumophila str. Paris	zinc metalloproteinase precursor	543	5e-20	0.33	0.50
DAYTHGKFVKTYYEDHFQRHSIDDR-GMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESY DA G +K Y D + ++ G P+ V+ + Y+NA+WDGK M +G+ T SL V GHE++HG TE +GLEY GQSG +NES+ DALYAGYVIKHMYHDWYGVEALTKSDGSPMQLVMRVHYGQGYENAYWDGKQMTFGDGDTMMYPLV--SLGVGGHEVSHGFTEQHSGLEYFGQSGGMNESF SDLMG----YIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ--NLGIEKAQTIFYS SD+ Y G ++ +IG + D +R + PS+ G +A DD YY VHY+SG+ N + Y + N + A + SDMAAQAAEYYSVGKNSWQIGPEIMKEDSGYDALRYMDKPSRDGMSIDVA--DD--------YYGGLDVHYSSGVYNHLFYILANQPNWNLRMAFDVMVK SLVNYLTPKAQFSDARDAMLAAAK + ++Y TP + F + ML+AAK ANMDYWTPYSTFDEGGCGMLSAAK
Show aligned area	148360917	Legionella pneumophila str. Corby	zinc metalloprotease	543	5e-20	0.33	0.50
DAYTHGKFVKTYYEDHFQRHSIDDR-GMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESY DA G +K Y D + ++ G P+ V+ + Y+NA+WDGK M +G+ T SL V GHE++HG TE +GLEY GQSG +NES+ DALYAGYVIKHMYHDWYGVEALTKSDGSPMQLVMRVHYGQGYENAYWDGKQMTFGDGDTMMYPLV--SLGVGGHEVSHGFTEQHSGLEYFGQSGGMNESF SDLMG----YIISGASNPEIGADTQSVDRK-TGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ--NLGIEKAQTIFYS SD+ Y G ++ +IG + D +R + PS+ G +A DD YY VHY+SG+ N + Y + N + A + SDMAAQAAEYYSVGKNSWQIGPEIMKEDSGYDALRYMDKPSRDGMSIDVA--DD--------YYGGLDVHYSSGVYNHLFYILANQPNWNLRMAFDVMVK SLVNYLTPKAQFSDARDAMLAAAK + ++Y TP + F + ML+AAK ANMDYWTPYSTFDEGGCGMLSAAK
Show aligned area	21223804	Streptomyces coelicolor A3(2)	hypothetical protein SCO5446	549	4e-19	0.27	0.40
AAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKI--------------QSVDAIGEEGVKKIIASDNPETKDL A E+ V D +D G H + E+ +G+ V ++++H +GA VT + VK+ Q++ A + G K A P + + GAKEKLVVKDVVKDRDGSVHTRYERTYDGLPVLGGDLVVHRSESGATRGVT-KATEAAVKVATVTPKVKAAKAEQQALSAAKDAGSSKTAADSAP--RKV VFLAIDKRVNNEGQLFYKVRVTS-SPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEV-TLKNSFQVAFNVPVEKS-------NTGIALHGTDN-----T ++ A K V L Y+ V G P L +A G L E+ G E + K+ + + +S +TG H T N + IWAAQGKPV-----LAYETVVGGLQDDGTPNELHVITDADTGA-----KLYEYQGIETGSGKSLYSGTVELGTTRSGSSYQLYDTGRGGHKTYNLARKTS GVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKA--MRYGETSTPTGKTYASSLD G D + + A S AVDA + +Y++ F R I + G S V + Y NAFW M YG+ + T +SLD GTGTLFTDADDTWGTGAASSDPQDQTAAVDAAYGAQVTWDFYKESFGRSGIKNDGKAAYSRV--HYGSNYVNAFWSDSCFCMTYGDGTGNTNPL--TSLD VVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASNPE-------IGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQG- V GHEM+HGVT +TAGL Y G+SG LNE+ SD+ G + +N IG T +R + PSK G + Y+D G VAGHEMSHGVTSNTAGLNYSGESGGLNEATSDIFGTGVEYFANSSADKGDYLIGERIDINGDGTPLRYMDEPSKDGASKD--------------YWDSGL ---GVHYNSGIINRIGY-----------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEA VHY+SG N + + + +G +KA I+Y +L Y+T ++DAR A L+AA YG ++ GGVDVHYSSGPANHFFFLLSEGSGARTVDGVDYDSPTSDGSTVTGIGRDKALQIWYKALTEYMTSTTDYADARTATLSAASDLYGADS
Show aligned area	114048075	Shewanella sp. MR-7	vibriolysin	500	1e-18	0.33	0.51
YDNAFWDGKAMRYGETSTPTGKTY---ASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTGIRNLQT Y+NAFWDG AM +G+ G +Y SLDV HE++HG TE +GL Y GQSG +NE++SD+ G + + G+++ ++G D V +R + YENAFWDGSAMSFGD-----GASYFYPLVSLDVSAHEVSHGFTEQNSGLNYSGQSGGINEAFSDIAGEAAEFYMRGSNDWKVGYDI--VKGSGALRYMDN PSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAF P K G+ D+ A Y + VHY+SG+ N+ YT+ G KA +F + Y TP + F+ A + AA + + V+AAF PPKDGR-----SIDNAANYTSSM-----DVHYSSGVFNKAFYTLATKSGWNTRKAFDVFVLANQMYWTPTSTFNQAACGVQQAASAKGSAYPVADVTAAF NSAGIGAK G+ + AVVGVSCQ
Show aligned area	117921122	Shewanella sp. ANA-3	vibriolysin	500	2e-18	0.34	0.52
YDNAFWDGKAMRYGETSTPTGKTY---ASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTGIRNLQT Y+NAFWDG AM +G+ G +Y SLDV HE++HG TE +GL Y GQSG +NE++SD+ G + + G+++ ++G D V +R + YENAFWDGSAMSFGD-----GASYFYPLVSLDVSAHEVSHGFTEQNSGLNYSGQSGGINEAFSDIAGEAAEFYMRGSNDWKVGYDI--VKGNGALRYMDN PSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAF P+K G+ D+ A Y + VHY+SG+ N+ YT+ G KA +F + Y TP + F+ A + AA + + V+AAF PTKDGR-----SIDNAANYTSSM-----DVHYSSGVFNKAFYTLATKNGWDTRKAFDVFVLANQLYWTPTSTFNKAACGVQQAASAKGSGYPVADVAAAF NSAGI + G+ LAVGV
Show aligned area	83718299	Burkholderia thailandensis E264	thermolysin metallopeptidase	565	2e-18	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKIIASDNPET------------ +A + A +Q+ V D DA G +H++ ++ G+ V +V++H ++ + + Q I IG+ G ++ + + P+ QAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQG----QLKQASLTQPAPINLAGKIGKVG-ERFVVRNAPDVGADAARRVAARR ----------KDLVFLAIDKRVNNEGQLFYKVRVTSSPT-GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNT DLV A D L Y VRV T +++Y V+A G +++ QDL + + T ++ + ++ +++ T A D T FGADLRRVDGADLVVFARDA----APTLAYAVRVYGKATDAHGEAVIYYVDARTGDVLDAQDLIKTASATGTGRSLYYGNLSLTTDQTGTN-AYRLLDPT GVYHAVVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGK +V DG+ N+ I + + V N D T + YY+ R+ I + G + S V D NA W + RGGGSVYDGRGLSSDEVEQSNDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKATHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSR AMRYGETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPE M YG+ T S+DV GHEM+HGVTE TA L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ VMVYGDGEPGTRLPKPVVSVDVAGHEMSHGVTEATANLNYSGDAGGLNESTSDIFGTLVKYYANNPNDPGNYVIGARITS----GGLRKMYKQDLDGR-- TMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGY-------------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAK + + Y P +D HY SG+ NR Y T LG +KA I+Y +L YLT + + AR A + AA SYSCYPSGGFSWANPRHDP---HYTSGVGNRFFYLLAEGPVAPSTDTGLSKSQLVCNGDTSFSGLGRDKAGKIWYRTLTVYLTTNSSYPSARRASIQAAN VQYGDEAA--SVVSAAFNSAGI YG ++A + V+ A+++ G+ DLYGAKSAESATVARAWSAVGV
Show aligned area	78060277	Burkholderia sp. 383	ZmpA peptidase	565	2e-18	0.26	0.42
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDR----NGAVTSVT--------GNPVDQVVKIQSVDAIGEEGVKKIIA----SD +A + A +Q+ V D D G +H++ ++ G+ V +V++H + +VT + G D+ V I++ +G VK+I A SD QASAPADGDQFQVRDVIVDPDGTEHVRFDRFYAGLPVIGGDVVVHSSKGQLKQASVTQLAPINLAGNIGKVGDRSV-IRNAPDVGAARVKRIAAARFNSD NPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPT---GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYH D + + V L Y VRV T GD V +Y V+A +GT+++ QDL + + T ++ + + +++ T A D + VRRVDDAELVVFARDVTP--TLAYAVRVYGKATDAHGDAV--LYYVDARNGTVLDAQDLIKTAAATGTGRSLYYGNLTLTTDQTGTN-AYRMLDPSRGSG AVVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAMRY +V DG+ + I + + V N D T + YY+ R+ I + G + S V + NA W + M Y SVYDGRGLTSDDVEQATDLPIFTSSTNVWGNNTTTDRQTVAADIDYGLALTWDYYKTMHNRNGIFNDGRGVKSYAHVVFNTGSGTTGANAAWLNSHVMVY GE----TSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPET G+ TS P S+DV GHEM+HGVTE TA L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + GDGQPGTSLPKP---VVSVDVAGHEMSHGVTEATANLNYSGDAGGLNESTSDIFGTLVKYYANNPNDPGNYVIGARVVS----GGLRKMYKQDLDGR--S MAQYDDRARYKGTPYYDQGGVHYNSGIINRIGY-------------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKV + Y P +D H+ SG+ NR+ Y T +G EKA I+Y +L YL + + +AR A + AA FSCYPSGGFSWSNPRHDP---HFTSGVGNRLFYLLAEGPTVPSTDTGLTKAQLVCNGDTTFSGVGREKAGKIWYRTLTVYLNANSSYPNARRASIQAAND QYGDEAA--SVVSAAFNSAGI YG +A + V+ A+++ G+ LYGANSAESTAVARAWSAVGV
Show aligned area	54292984	Legionella pneumophila str. Lens	hypothetical protein lpl0020	558	3e-18	0.31	0.45
DAYTHGKFVKTYYEDHFQRHSID-DRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYAS--SLDVVGHEMTHGVTEHTAGLEYLGQSGALNE DAY G + Y+D + +++ G P+ V+ YDNAFWDG+AM +G+ G + SLDV GHE+THG TE +GLEY QSGALNE DAYYFGHVIVGMYKDWYGLNALQHSNGAPMQLVMRVHFGQNYDNAFWDGQAMSFGD-----GLDFYPLVSLDVAGHEVTHGFTEQHSGLEYHDQSGALNE SYSDLMG-----YIISGASNPE---------------IGADTQSVDRKTGIRNLQTPSKHGQP-----ETMAQ---------YDDRARYKGT----PYYD S SD+ G Y++ NP+ IG +R + PS G + +AQ YD+ Y T P SLSDMAGQASRAYLLE--KNPQLYNKAYLQPNEVTWGIGETIVRDSYGKALRFMDYPSSDGSSADCLDKGIAQNNGSYCAISYDEVVAYANTHIALPQER QGG-VHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI Q VH SG+ N+ Y + +++GI+ A I + Y TP F + ++ AA+ D + V +AF GI QSFIVHTASGVFNKAFYLMSKDMGIKNAYHIMVVANTKYWTPTTDFKNGACGVIYAARDLNTD--INKVKSAFGQVGI
Show aligned area	52840275	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	hemagglutinin/protease, zinc metalloprotease	560	3e-18	0.31	0.45
DAYTHGKFVKTYYEDHFQRHSID-DRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYAS--SLDVVGHEMTHGVTEHTAGLEYLGQSGALNE DAY G + Y+D + +++ G P+ V+ YDNAFWDG+AM +G+ G + SLDV GHE+THG TE +GLEY QSGALNE DAYYFGHVIVGMYKDWYGLNALQHSNGAPMQLVMRVHFGQNYDNAFWDGQAMSFGD-----GLDFYPLVSLDVAGHEVTHGFTEQHSGLEYHDQSGALNE SYSDLMG-----YIISGASNPE---------------IGADTQSVDRKTGIRNLQTPSKHGQP-----ETMAQ---------YDDRARYKGT----PYYD S SD+ G Y++ NP+ IG +R + PS G + +AQ YD+ Y T P SLSDMAGQASRAYLLE--KNPQLYNKAYLQPNEVTWGIGETIVRDSYGKALRFMDYPSSDGSSADCLDKGIAQNNGSYCAISYDEVVAYANTHIALPQER QGG-VHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI Q VH SG+ N+ Y + +++GI+ A I + Y TP F + ++ AA+ D + V +AF GI QSFIVHTASGVFNKAFYLMSKDMGIKNAYHIMVVANTKYWTPTTDFKNGACGVIYAARDLNTD--INKVKSAFGQVGI
Show aligned area	53722576	Burkholderia pseudomallei K96243	peptidase	565	4e-18	0.25	0.42
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRN--GAVTSVTGNPVDQVVKIQSVDA---------IGEEGVKKIIASD----- +A + A +Q+ V D DA G +H++ ++ G+ V +V++H ++ + P+D KI V +G + +++ + QAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGADV -NPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPT-GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHA + DLV A D L Y VRV T +++Y V+A G +++ QDL + T ++ + ++ +++ T A D T + RRVDGADLVVFARDA----APTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQTGTN-AYRMLDPTRGSGS VVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAMRYG V DG+ ++ I + + V N D T + YY+ R+ I + G + S V D NA W + M YG VYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYG ETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETMAQY + T S+DV GHEM+HGVTE T+ L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + + Y DGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNESTSDIFGTLVKYYANNPNDPGNYVIGARITS----GGLRKMYKQDLDGR--SYSCY DDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ-------------------------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD P +D HY SG+ NR Y + + LG +KA I+Y +L YLT + ++ AR A + AA YG PSGGFSWANPRHDP---HYTSGVGNRFFYLLAEGPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYTGARRASIQAANDLYGV EA--ASVVSAAFNSAGI + ++ V+ A+++AG+ NSLESATVARAWSAAGV
Show aligned area	148358159	Legionella pneumophila str. Corby	hemagglutinin/protease, zinc metalloprotease	558	5e-18	0.31	0.45
DAYTHGKFVKTYYEDHFQRHSID-DRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYAS--SLDVVGHEMTHGVTEHTAGLEYLGQSGALNE DAY G + Y+D + +++ G P+ V+ YDNAFWDG+AM +G+ G + SLDV GHE+THG TE +GLEY QSGALNE DAYYFGHVIVGMYKDWYGLNALQHSNGAPMQLVMRVHFGQNYDNAFWDGQAMSFGD-----GLDFYPLVSLDVAGHEVTHGFTEQHSGLEYHDQSGALNE SYSDLMG-----YIISGASNPE---------------IGADTQSVDRKTGIRNLQTPSKHGQP-----ETMAQ---------YDDRARYKGT----PYYD S SD+ G Y++ NP+ IG +R + PS G + +AQ YD+ Y T P SLSDMAGQASRAYLLE--KNPQLYNKAYLQPNEVTWGIGETIVRDSYGKALRFMDYPSSDGSSADCLDKGIAQNNGSYCAISYDEVVAYANTHIALPQER QGG-VHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI Q VH SG+ N+ Y + +++GI+ A I + Y TP F + ++ AA+ D + V +AF GI QSFIVHTASGVFNKAFYLMSKDMGIKNAYHIMVVANTKYWTPTTDFKNGACGVIYAARDLNTD--INKVKSAFGQVGI
Show aligned area	76819684	Burkholderia pseudomallei 1710b	thermolysin metallopeptidase	565	6e-18	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRN--GAVTSVTGNPVDQVVKIQSVDA---------IGEEGVKKIIASD----- +A + A +Q+ V D DA G +H++ ++ G+ V +V++H ++ + P+D KI V +G + +++ + QAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGADV -NPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPT-GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHA + DLV A D L Y VRV T +++Y V+A G +++ QDL + T ++ + ++ +++ T A D T + RRVDGADLVVFARDA----APTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQTGTN-AYRMLDPTRGSGS VVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAMRYG V DG+ ++ I + + V N D T + YY+ R+ I + G + S V D NA W + M YG VYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYG ETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETMAQY + T S+DV GHEM+HGVTE T+ L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + + Y DGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNESTSDIFGTLVKYYANNPNDPGNYVIGARITS----GGLRKMYKQDLDGR--SYSCY DDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ-------------------------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD P +D HY SG+ NR Y + + LG +KA I+Y +L YLT + + AR A + AA YG PSGGFSWANPRHDP---HYTSGVGNRFFYLLAEGPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQAANDLYGV EA--ASVVSAAFNSAGI + ++ V+ A+++AG+ NSLESATVARAWSAAGV
Show aligned area	126446284	Burkholderia mallei NCTC 10247	thermolysin metallopeptidase	565	6e-18	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRN--GAVTSVTGNPVDQVVKIQSVDA---------IGEEGVKKIIASD----- +A + A +Q+ V D DA G +H++ ++ G+ V +V++H ++ + P+D KI V +G + +++ + QAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGADV -NPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPT-GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHA + DLV A D L Y VRV T +++Y V+A G +++ QDL + T ++ + ++ +++ T A D T + RRVDGADLVVFARDA----APTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQTGTN-AYRMLDPTRGSGS VVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAMRYG V DG+ ++ I + + V N D T + YY+ R+ I + G + S V D NA W + M YG VYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYG ETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETMAQY + T S+DV GHEM+HGVTE T+ L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + + Y DGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNESTSDIFGTLVKYYANNPNDPGNYVIGARITS----GGLRKMYKQDLDGR--SYSCY DDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ-------------------------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD P +D HY SG+ NR Y + + LG +KA I+Y +L YLT + + AR A + AA YG PSGGFSWANPRHDP---HYTSGVGNRFFYLLAEGPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQAANDLYGV EA--ASVVSAAFNSAGI + ++ V+ A+++AG+ NSLESATVARAWSAAGV
Show aligned area	53716301	Burkholderia mallei ATCC 23344	thermolysin metallopeptidase	565	6e-18	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRN--GAVTSVTGNPVDQVVKIQSVDA---------IGEEGVKKIIASD----- +A + A +Q+ V D DA G +H++ ++ G+ V +V++H ++ + P+D KI V +G + +++ + QAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGADV -NPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPT-GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHA + DLV A D L Y VRV T +++Y V+A G +++ QDL + T ++ + ++ +++ T A D T + RRVDGADLVVFARDA----APTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQTGTN-AYRMLDPTRGSGS VVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAMRYG V DG+ ++ I + + V N D T + YY+ R+ I + G + S V D NA W + M YG VYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYG ETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETMAQY + T S+DV GHEM+HGVTE T+ L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + + Y DGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNESTSDIFGTLVKYYANNPNDPGNYVIGARITS----GGLRKMYKQDLDGR--SYSCY DDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ-------------------------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD P +D HY SG+ NR Y + + LG +KA I+Y +L YLT + + AR A + AA YG PSGGFSWANPRHDP---HYTSGVGNRFFYLLAEGPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQAANDLYGV EA--ASVVSAAFNSAGI + ++ V+ A+++AG+ NSLESATVARAWSAAGV
Show aligned area	126457464	Burkholderia pseudomallei 1106a	thermolysin metallopeptidase	585	6e-18	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRN--GAVTSVTGNPVDQVVKIQSVDA---------IGEEGVKKIIASD----- +A + A +Q+ V D DA G +H++ ++ G+ V +V++H ++ + P+D KI V +G + +++ + QAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGADV -NPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPT-GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHA + DLV A D L Y VRV T +++Y V+A G +++ QDL + T ++ + ++ +++ T A D T + RRVDGADLVVFARDA----APTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQTGTN-AYRMLDPTRGSGS VVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAMRYG V DG+ ++ I + + V N D T + YY+ R+ I + G + S V D NA W + M YG VYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYG ETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETMAQY + T S+DV GHEM+HGVTE T+ L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + + Y DGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNESTSDIFGTLVKYYANNPNDPGNYVIGARITS----GGLRKMYKQDLDGR--SYSCY DDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ-------------------------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD P +D HY SG+ NR Y + + LG +KA I+Y +L YLT + + AR A + AA YG PSGGFSWANPRHDP---HYTSGVGNRFFYLLAEGPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQAANDLYGV EA--ASVVSAAFNSAGI + ++ V+ A+++AG+ NSLESATVARAWSAAGV
Show aligned area	124381794	Burkholderia mallei NCTC 10229	thermolysin metallopeptidase	585	6e-18	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRN--GAVTSVTGNPVDQVVKIQSVDA---------IGEEGVKKIIASD----- +A + A +Q+ V D DA G +H++ ++ G+ V +V++H ++ + P+D KI V +G + +++ + QAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGADV -NPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPT-GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHA + DLV A D L Y VRV T +++Y V+A G +++ QDL + T ++ + ++ +++ T A D T + RRVDGADLVVFARDA----APTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQTGTN-AYRMLDPTRGSGS VVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAMRYG V DG+ ++ I + + V N D T + YY+ R+ I + G + S V D NA W + M YG VYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYG ETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETMAQY + T S+DV GHEM+HGVTE T+ L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + + Y DGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNESTSDIFGTLVKYYANNPNDPGNYVIGARITS----GGLRKMYKQDLDGR--SYSCY DDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ-------------------------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD P +D HY SG+ NR Y + + LG +KA I+Y +L YLT + + AR A + AA YG PSGGFSWANPRHDP---HYTSGVGNRFFYLLAEGPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQAANDLYGV EA--ASVVSAAFNSAGI + ++ V+ A+++AG+ NSLESATVARAWSAAGV
Show aligned area	119717390	Nocardioides sp. JS614	griselysin	527	7e-18	0.24	0.40
YTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLV-------FLAIDKRVNNE +TV DA G H+++++ G+ V ++++H G V+ ++ V + + A+G+ + T+ L +D FTVTHTVTDADGSTHVRMDRTYRGLPVLGGDLVVHRGTQGGWRGVS-QTLENEVHVSTTPAVGKAAAAVRALAPAKATRGTTGAKTQSTRLVVDATTGTA GQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEK-QDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKN-------------- + + + G P L V+A G ++ + Q + GS +L + VP++ + +G D T D N RLAWEVITGGTQQDGTPSRLATYVDARTGAVIRREQQIQTADGSGQSLYSG-----TVPLQLTLSGSTYQLKDPTRGNTYTTDMGNASDSLGCQYFGFNC -NYSIIQAPSLVALN-------QNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYAS--SLDVVG ++ +P + N AVDA +Y+ + R+ I G + V + Y NAFWDG M YG+ G Y SLDV G KTGTLFTSPDNLFGNGATSSRESAAVDAQYGTNMTWDFYKSTYGRNGIFGTGAGSYNRV--HYGKNYVNAFWDGTKMTYGDGD---GTNYGPLVSLDVAG HEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYII----SGASNPEIGADTQSVDRKT--GIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYN HEM+HGVTE+TAGL Y G+SG LNE+ SD+ G ++ + A++P + D K G R + P+ G + ++ + G+ VHY+ HEMSHGVTENTAGLAYSGESGGLNEATSDIFGTMVEFFAANANDPGDYLIGEEFDLKNHLGFRRMDNPASDG-----SSFNCWSSTVGS-----ADVHYS SGIINRIGY-----------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAA SG+ N Y + + +G + A I+Y +L Y+T ++ AR A L AA+ YG +A SGVGNHFFYLLAEGSGAKTIGGVAHNSPTCNGSTVTGIGRDAASAIWYRALTVYMTSSTSYAGARTATLNAARDLYGAGSA
Show aligned area	49185401	Bacillus anthracis str. Sterne	thermolysin metallopeptidase	530	8e-18	0.35	0.50
GKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG-----YIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGT G + D+ GHE TH VT + LE+ G+SGA+NE+ SD+MG YI +G N IG + SV +R+++ PS + + DD ++Y GDPMVRAFDIAGHEFTHAVTSSESNLEFFGESGAINEALSDIMGTAIEKYINNGKFNWTIGEQSGSV-----LRDMKNPSSVKFFDGVPYPDDYSKYSDL PYYDQGGVHYNSGIINRIGYTIIQ----------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFNSAGIGA--KED D GVH+NS IIN++ Y I Q +G +K IFY + + L + FS+ R A L A +YG + V V AF++A I KED NGEDNEGVHFNSSIINKVAYLIAQGGTHNGVTVNGIGEDKMFDIFYYANTDELNMTSNFSELRLACLKVATNKYGANSIEVETVQKAFDAAKIKGPVKED --IQVNQPSE +VNQ E EKTEVNQVPE
Show aligned area	126444165	Burkholderia pseudomallei 668	thermolysin metallopeptidase	585	8e-18	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRN--GAVTSVTGNPVDQVVKIQSVDA---------IGEEGVKKIIASD----- +A + A +Q+ V D DA G +H++ ++ G+ V +V++H ++ + P+D KI V +G + +++ + QAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGADV -NPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPT-GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHA + DLV A D L Y VRV T +++Y V+A G +++ QDL + T ++ + ++ +++ T A D T + RRVDGADLVVFARDA----APTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQTGTN-AYRMLDPTRGGGS VVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAMRYG V DG+ ++ I + + V N D T + YY+ R+ I + G + S V D NA W + M YG VYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYG ETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETMAQY + T S+DV GHEM+HGVTE T+ L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + + Y DGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNESTSDIFGTLVKYYANNPNDPGNYVIGARITS----GGLRKMYKQDLDGR--SYSCY DDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ-------------------------NLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGD P +D HY SG+ NR Y + + LG +KA I+Y +L YLT + + AR A + AA YG PSGGFSWANPRHDP---HYTSGVGNRFFYLLAEGPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQAANDLYGV EA--ASVVSAAFNSAGI + ++ V+ A+++AG+ NSLESATVARAWSAAGV
Show aligned area	156974791	Vibrio harveyi ATCC BAA-1116	protease	673	9e-18	0.26	0.42
AAEEQVYSESEVSTVLSKLEKEAISEAAAE-QYTVVDRKEDAWGMKHLKLEKQTE-GVTVDSDNVIIHLDRNGAVTSVTGNPV-------DQVVKIQSVD AA+ +S++++S L+ K + A+ E Y ++R E G + L ++Q GV V +V+ L G S+ GN V D + + S + AAQIVEHSQTDISEALNIAGKSSYMPASTELSYQNINRVE--IGQQTLVRKQQLHYGVPVYGHSVVADLSAKGFAQSIDGNVVVGIDNDLDSTLPMISAN AIGE--EGVKKIIAS-DNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNS-------------- E G ++ AS ++PE L + N L YKV P + V+A G IM++ + + +E N QAIEIATGTEQGFASNESPENDARAELMVWLDEQNTAHLIYKVDAVKIVNLRPSRPITLVDAKSGEIMDQWEGLAFLEAEGPGGNQKSGRYYFGPNTKFG -FQVAFNVPVEKSNT-GIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAF FQV + N I ++ G H NNY I + +N DA+ G+ V Y + I + + + Y NAF GFQVDQYCQMNSDNVETINMNNQQWGGQVHRFNCNVNNYREING-AYAPMN----DAHYFGQRVFDMYREWLGARPIQQK-----LTMRVHYGSNYGNAF WDGKAMRYGETSTPTGKTYASSL---DVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS----GASNPEIGADTQSVDRKTGIRNLQTPSKHG WDG+ M +G+ G +Y L DV+ HE++HG TE +GLEY G SG +NES+SD+ +S G+ N ++G + +R PS G WDGRQMTFGD-----GNSYMYPLATWDVIAHEVSHGFTEQNSGLEYRGMSGGMNESFSDVAAAALSQYVHGSFNWKMG--EHVMKYSPAMRYFINPSHDG QPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI ++ + YY VH++SGI N+ Y + + G I+KA + ++ Y TP + F + + AA+ + G E +S V++AF+ G+ A--SIGHVNQ--------YYRGIDVHHSSGIFNKAFYHLATSSGWSIKKAFMAYATANQLYWTPNSTFQQGAEGVCKAAQ-KLGYE-SSAVTSAFSQVGV
Show aligned area	34495512	Chromobacterium violaceum ATCC 12472	class 4 metalloprotease	489	9e-18	0.32	0.49
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGE---TSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE DA+ G V Y+D F I + + + + Y+NAFWDG AM +G+ T P SLDV HE++HG TE +GL Y GQSG +NE DAHYFGNVVFNLYKDWFNLKPITQKLL-----MKVHYSRNYENAFWDGTAMTFGDGYNTFYPL-----VSLDVSAHEVSHGFTEQNSGLVYSGQSGGINE SYSDLMG----YIISGASNPEIGADTQSVDRKTG-IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ--NLGIEKAQTIF ++SD+ G Y + G ++ +GA+ + +KTG +R P+K GQ A+ YY+ VHY+SG+ N+ Y I N KA +F AFSDMAGEAAEYYMKGKNDFLVGAE---IFKKTGALRYFADPTKDGQSIGNAK----------DYYNGLDVHYSSGVYNKAFYLIATSPNWNTRKAFEVF YSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI + Y A ++ A ++ AA + + A V+ AF + G+ VDANRLYWNANATYNSAACGVVKAADARGYNSAD--VTKAFAAVGV
Show aligned area	169628935	Mycobacterium abscessus	putative metalloprotease	344	1e-17	0.33	0.50
NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL + +A A+T V +Y++ F R+S+DD GM ++S V + Y NAFW+G M YG+ + +S DV+GHE+THGVT++TAGL Y ++G L DASAKRAFTETAAVAKFYKECFGRNSVDDEGMTLVSSV--HYSVNYSNAFWNGSQMTYGDGDGEIFVDFTASNDVIGHELTHGVTQYTAGLLYKNEAGGL NESYSDLMGYIISGASNPE--------IGADT---QSVDRK-TGIRNLQTP-SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG NES SD+ G + S + IG D ++V + T +R++ P ++H + Y D Y H +SGI N Y G NESMSDVFGSMFRQWSAGQTVDQADWLIGKDIMGPRAVAKGFTCLRDMADPGARHCLAPQPSHYRD--------YVPGSDPHESSGIPNYAFYLAATKHG IEKAQ---TIFYSSLVNYLTPKAQ Q T++Y +L +PKA+ SYSWQGVGTVWYEALT---SPKAR
Show aligned area	54296002	Legionella pneumophila str. Paris	hypothetical protein lpp0019	558	1e-17	0.31	0.44
DAYTHGKFVKTYYEDHFQRHSID-DRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYAS--SLDVVGHEMTHGVTEHTAGLEYLGQSGALNE DAY G + Y+D + +++ G P+ V+ YDNAFWDG+AM +G+ G + SLDV GHE+THG TE +GLEY QSGALNE DAYYFGHVIVDMYKDWYGLNALQHSNGAPMQLVMRVHFGQNYDNAFWDGQAMSFGD-----GLDFYPLVSLDVAGHEVTHGFTEQHSGLEYHDQSGALNE SYSDLMG-----YIISGASNPE---------------IGADTQSVDRKTGIRNLQTPSKHGQP-----ETMAQ---------YDDRARYKGT----PYYD S SD+ G Y++ NP+ IG +R + PS G + +AQ YD+ Y P SLSDMAGQASRAYLLE--KNPQLYNKAYLQPNEVTWGIGETIVRDSYGKALRFMDYPSSDGSSADCLDKGIAQNNGSYCAINYDEVVAYANAHIALPQER QGG-VHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI Q VH SG+ N+ Y + +++GI+ A I + Y TP F + ++ AA+ D + V +AF GI QSFIVHTASGVFNKAFYLMSKDMGIKNAYHIMVVANTKYWTPTTDFKNGACGVIYAARDLNTD--INKVKSAFGQVGI
Show aligned area	170727469	Shewanella woodyi ATCC 51908	peptidase M4 thermolysin	499	1e-17	0.32	0.49
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQ--HPDAYDNAFWDGKAMRYGETSTPTGKTY---ASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL DA+ G + Y+D +Q P+ ++ + + Y+NAFWDG+AM +G+ G +Y SLDV HE++HG TE +GLEY GQSG + DAHYFGNVIFNMYQDWYQT-------APLTFQLEMRVHYGRRYENAFWDGRAMSFGD-----GDSYFYPLVSLDVSAHEVSHGFTEQNSGLEYSGQSGGI NESYSDLMG----YIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFY NES+SD+ G + + G+++ ++G D V +R + P++ G A Y Y D VHY+SG+ NR Y + G + ++ NESFSDMAGEAAEFYMRGSNDWKVGYDI--VKGSGALRYMDDPTQDGNSIGDASY----------YTDGMDVHYSSGVFNRAFYLLSNKTGWDTHKSFDV SSLVNYLTPKAQFSDARDAMLAA L N L A SD +DA A FVLANQLYWSAT-SDFKDAACGA
Show aligned area	29829337	Streptomyces avermitilis MA-4680	neutral zinc metalloprotease	554	4e-17	0.25	0.40
LFVAAEEQVYSESEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKI---------- L AA + ++E +T + + I E+ V D +DA G H + E+ G+ V ++++H ++G VT +K+ LSAAARTSLIKKAEAATPETA---QQIGLGTKEKLVVRDVVKDADGTLHTRYERTYNGLPVLGGDLVVHQSKSGTTEGVT-KATKATIKVASLKPQITSA ----QSVDAIGEEGVKKIIASDNPET--------KDLVFLAIDKRVNNEGQLFYKVRVTSSPTGDPVSLVYKVNATDGTIMEKQDLTEHV---GSEVTLK Q++ G +K A P L F + + ++G +T + TG + + G + +T + GS L KAEKQALTVAKSAGSEKTSADRAPRKVIWAGNGKPTLAFETVVGGLQDDGTPNQLHVITDAATGKKLYEYQAIETGTGKTLYSGTVTLNTTLSGSTYQLT NSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAF + + + KS+T + GT T D + + A S A DA + +Y++ F R I + G+ S V + +AY NAF DGTRGSHKT-YNKSHTTTSSAGTLFT-------DADDTWGTGAASSSTTDQTAAADAAYGAQVTWDFYKNTFGRSGIKNNGVAAYSRV--HYGNAYVNAF WDGKA--MRYGETSTPTGKTYA-SSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYII-------SGASNPEIGADTQSVDRKTGIRNLQTPS WD M YG+ S G T+ +SLDV GHEM+HGVT +TAGL Y G+SG LNE+ SD+ G + S + IG T +R + PS WDDSCFCMTYGDGS---GNTHPLTSLDVAGHEMSHGVTANTAGLNYSGESGGLNEATSDIFGTGVEFYAANSSDVGDYLIGEKININGDGTPLRYMDKPS KHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGY-----------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAML K G D + G VHY+SG+ N Y + + +G KA I+Y +L Y T +++ AR L KDG-----GSADSWSSSVGNL-----DVHYSSGVANHFFYLLSEGSGSKTINGVTYNSPTSNGSTVTGIGRAKALQIWYKALTTYFTSTTKYAAARTGTL AAAKVQYGDEAAS--VVSAAFNSAGI +AA YG + V+AA+++ + SAASALYGSTSTEYKAVAAAWSAVNV
Show aligned area	116686975	Burkholderia cenocepacia HI2424	propeptide, peptidase M4 and M36	565	6e-17	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKII--ASDNPETKDLVFLAI-- +A + +Q+ V D D G +H++ ++ G+ V +V++H + + V Q+ I IG+ G + ++ A D T+ A QAAAPTDGDQFQVRDVIVDPDGTEHVRFDRFHAGLPVIGGDVVVHSSKG----QLKQASVTQLAPINLAGTIGKVGNRAVVRNAPDVGATRARHIAAARF --DKRVNNEGQLF-----------YKVRVTSSPT---GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNT-----------GI D R ++ +L Y VRV T GD V +Y V+A GT+++ QDL + + T ++ + + +++ T G NSDVRRVDDAELVVFARDVTPTLAYAVRVYGKATDTHGDAV--LYYVDARTGTVLDAQDLIKTAAATGTGRSLYYGNLTLTTDQTGTNAYRMLDPGRGGG ALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAM +++ D G+ V+ + I + + V N D T + YY+ R+ I + G + S V + NA W + M SVY--DGRGLSSDEVEQATDLPIFTSSTNVWGNNTTTDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVKSYAHVVFNTGSGTTGANAAWLSSRVM RYGETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETM YG+ T S+DV GHEM+HGVTE TA L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + AYGDGEPGTRLPKPVVSVDVAGHEMSHGVTEATANLNYSGDAGGLNESTSDIFGTLVKFYANNPNDPGNYVIGARVVS----GGLRKMYKQDLDGR--SF AQYDDRARYKGTPYYDQGGVHYNSGIINRIGY-------------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQ + Y P +D H++SG+ NR Y T LG +KA I+Y +L YL + + +AR A + AA SCYPSGGFSWSNPRHDP---HFSSGVGNRFFYLLSEGPSVPSTDTGLSRAQLVCNGDTTFSGLGRDKAGKIWYRTLTVYLNANSSYPNARRASIQAANDL YGDEAA--SVVSAAFNSAGI YG +A + V+ A+++ G+ YGANSAESATVARAWSAVGV
Show aligned area	107022786	Burkholderia cenocepacia AU 1054	propeptide, peptidase M4 and M36	565	6e-17	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKII--ASDNPETKDLVFLAI-- +A + +Q+ V D D G +H++ ++ G+ V +V++H + + V Q+ I IG+ G + ++ A D T+ A QAAAPTDGDQFQVRDVIVDPDGTEHVRFDRFHAGLPVIGGDVVVHSSKG----QLKQASVTQLAPINLAGTIGKVGNRAVVRNAPDVGATRARHIAAARF --DKRVNNEGQLF-----------YKVRVTSSPT---GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNT-----------GI D R ++ +L Y VRV T GD V +Y V+A GT+++ QDL + + T ++ + + +++ T G NSDVRRVDDAELVVFARDVTPTLAYAVRVYGKATDTHGDAV--LYYVDARTGTVLDAQDLIKTAAATGTGRSLYYGNLTLTTDQTGTNAYRMLDPGRGGG ALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAM +++ D G+ V+ + I + + V N D T + YY+ R+ I + G + S V + NA W + M SVY--DGRGLSSDEVEQATDLPIFTSSTNVWGNNTTTDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVKSYAHVVFNTGSGTTGANAAWLSSRVM RYGETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETM YG+ T S+DV GHEM+HGVTE TA L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + AYGDGEPGTRLPKPVVSVDVAGHEMSHGVTEATANLNYSGDAGGLNESTSDIFGTLVKFYANNPNDPGNYVIGARVVS----GGLRKMYKQDLDGR--SF AQYDDRARYKGTPYYDQGGVHYNSGIINRIGY-------------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQ + Y P +D H++SG+ NR Y T LG +KA I+Y +L YL + + +AR A + AA SCYPSGGFSWSNPRHDP---HFSSGVGNRFFYLLSEGPSVPSTDTGLSRAQLVCNGDTTFSGLGRDKAGKIWYRTLTVYLNANSSYPNARRASIQAANDL YGDEAA--SVVSAAFNSAGI YG +A + V+ A+++ G+ YGANSAESATVARAWSAVGV
Show aligned area	119774338	Shewanella amazonensis SB2B	peptidase M4, thermolysin	485	7e-17	0.32	0.51
YDNAFWDGKAMRYGETSTPTGKTY---ASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTGIRNLQT Y+NAFWDG+AM +G+ G +Y SLDV HE++HG TE +GLEY QSG +NE++SD+ G + + G+++ +G D +R + YENAFWDGRAMSFGD-----GASYFYPLVSLDVSAHEVSHGFTEQNSGLEYSAQSGGMNEAFSDMAGEAAEFFMRGSNDWMVGHDI--FKGNGALRYMDD PSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAF P+K D R+ + Y VHY+SG+ N+ Y + + G KA +F + +Y T + ++ + AAA + A S V+AAF PTK----------DGRSIGHASDYTSGMDVHYSSGVYNKAFYLLAKKNGWDTRKAFEVFVLANQHYWTATSNYNQGACGVEAAASDK--GYAVSDVTAAF NSAGIGAK S G+ + ASVGVSCQ
Show aligned area	29827578	Streptomyces avermitilis MA-4680	neutral zinc metalloprotease	791	8e-17	0.30	0.45
YYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKA--MRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISG YY+D F R+ I + G+ S + +AY NAFW M YG+ ++ T ++LDV HEM+HGVT TA L Y G+SG LNE+ SD+ + YYKDVFGRNGIRNDGVAAYS--RAHYGNAYVNAFWSDTCFCMTYGDGASNTHPL--TALDVAAHEMSHGVTSATANLTYSGESGGLNEATSDIFAAAVEF ASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTI-----------------------IQNLGIEKA ++ V K IR TP ++ + D +R VHY+SG N Y + + +GIE A HADLPADVPDYLVGEKIDIRGNGTPLRYMDKPSK---DGSSRDSWDSSLGSIDVHYSSGPANHFFYLLSEGSGAKTVNGVSYDSPTSDGKAVTGIGIENA QTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKEDI Q I+Y +L Y+T ++ AR A L AA +G + + ++ A AGI + I QRIWYRALTTYMTSTTNYAGARVATLQAAADLFGAYSDTYLAVAAAWAGINVGDRI
Show aligned area	197295256	Burkholderia cenocepacia J2315	zinc metalloprotease ZmpA	565	8e-17	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKII--ASDNPETKDLVFLAI-- +A + +Q+ V D D G +H++ ++ G+ V +V++H + + V Q+ I +IG+ G + +I A D T+ A QAGAPTDGDQFQVRDVIVDPDGTEHVRFDRFHAGLPVIGGDVVVHSSKG----QLKQASVTQLAPINLAGSIGKVGNRAVIRNAPDVGATRARHIAAARF --DKRVNNEGQLF-----------YKVRVTSSPT---GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVY D R ++ +L Y VRV T GD V +Y V+A GT+++ QDL + + T ++ + + +++ T A D + NSDVRRVDDAELVVFARDVTPTLAYAVRVYGKATETHGDAV--LYYVDARTGTLLDAQDLIKTAAATGTGRSLYYGNLTLTTDQTGTN-AYRMLDPSRGG HAVVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAMR +V DG+ + I + + V N D T + YY+ R+ I + G + S V + NA W + M GSVYDGRGLSSDEVEQATDLPIFTSSTNVWGNNATTDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVKSYAHVVFNTGSGTTGANAAWLSSRVMA YGETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETMA YG+ T S+DV GHEM+HGVTE TA L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + + YGDGEPGTRLPKPVVSVDVAGHEMSHGVTEATANLNYSGDAGGLNESTSDIFGTLVKFYANNPNDPGNYVIGARVVS----GGLRKMYKQDLDGR--SFS QYDDRARYKGTPYYDQGGVHYNSGIINRIGY-------------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQY Y P +D H+ SG+ NR Y T LG +KA I+Y +L YL + + +AR A + AA Y CYPSGGFSWSNPRHDP---HFTSGVGNRFFYLLSEGPSVPPTDTGLSRTQLVCNGDTTFSGLGRDKAGKIWYRTLTVYLNANSSYPNARRASIQAANDLY GDEAA--SVVSAAFNSAGI G +A + V+ A+++ G+ GANSAESATVARAWSAVGV
Show aligned area	170734704	Burkholderia cenocepacia MC0-3	peptidase M4 thermolysin	565	9e-17	0.25	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKII--ASDNPETKDLVFLAI-- +A + +Q+ V D D G +H++ ++ G+ V +V++H + + V Q+ I IG+ G + ++ A D T+ A QAAAPTDGDQFQVRDVIVDPDGAEHVRFDRFHAGLPVIGGDVVVHSSKG----QLKQASVTQLAPINLAGTIGKVGNRAVVRNAPDVGATRARHIAAARF --DKRVNNEGQLF-----------YKVRVTSSPT---GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNT-----------GI D R ++ +L Y VRV T GD V +Y V+A GT+++ QDL + + T ++ + + +++ T G NSDVRRVDDAELVVFARDVTPTLAYAVRVYGKATDTHGDAV--LYYVDARTGTLLDAQDLIKTAAATGTGRSLYYGNLTLTTDQTGTNAYRMLDPGRGGG ALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAM +++ D G+ V+ + I + + V N D T + YY+ R+ I + G + S V + NA W + M SVY--DGRGLSSDEVEQATDLPIFTSSTNVWGNNTTTDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVKSYAHVVFNTGSGTTGANAAWLSSRVM RYGETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETM YG+ T S+DV GHEM+HGVTE TA L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + AYGDGEPGTRLPKPVVSVDVAGHEMSHGVTEATANLNYSGDAGGLNESTSDIFGTLVKFYANNPNDPGNYVIGARVVS----GGLRKMYKQDLDGR--SF AQYDDRARYKGTPYYDQGGVHYNSGIINRIGY-------------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQ + Y P +D H++SG+ NR Y T LG +KA I+Y +L YL + + +AR A + AA SCYPSGGFSWSNPRHDP---HFSSGVGNRFFYLLSEGPSVPSTDTGLSRAQLVCNGDTTFSGLGRDKAGKIWYRTLTVYLNANSSYPNARRASIQAANDL YGDEAA--SVVSAAFNSAGI YG +A + V+ A+++ G+ YGANSAESATVARAWSAVGV
Show aligned area	156976740	Vibrio harveyi ATCC BAA-1116	zinc metalloprotease	780	9e-17	0.31	0.49
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTY---ASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE DA+ G V Y++ F D + ++ + Y+NAFWDG+AM +G+ G++Y SLDV HE++HG TE +GL Y QSG +NE DAHYFGNIVFDMYKNWF-----DTAPLTFKLMMRVHYGTGYENAFWDGQAMTFGD-----GESYFYPLVSLDVSAHEVSHGFTEQNSGLVYANQSGGMNE SYSDLMG----YIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFY ++SD+ G Y + G ++ +G D D +R + PS+ G AQ YYD VHY+SG+ N+ Y + G +KA +F AFSDIAGEAAEYYMKGENDWMVGKDIFKED--GALRYMDDPSRDGSSINHAQ----------DYYDGLNVHYSSGVFNKAFYHLATTDGWDTKKAFELFV SSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSA + Y + + F + + +AA G +A++VV+A LANQIYWSQDSNFWEGACGVKSAA-TDLGYDASAVVNA
Show aligned area	37677125	Vibrio vulnificus YJ016	Zinc metalloprotease, vibriolysin	636	1e-16	0.28	0.46
LTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV + + VG+ T++NS V V ++ +G + Y G +NY+ +A + N DA+ GK V Y+D ++ + + VIDKVGTTCTMENS--VVKTVDLQNRTSG--------STAYSYSCPGASNYNDHKAVNGAYSPLN--DAHYFGKVVYDMYKDW-----MNTAPLTFKLTM DEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLD--VVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTG + Y+NAFWDG AM +G+ ++ T+ +D V HE++HG TE +GL Y SG +NE++SD+ G + + G+ + +GAD G RVHYSSNYENAFWDGSAMTFGDGAS----TFYPLVDINVSAHEVSHGFTEQNSGLIYSNMSGGMNEAFSDIAGEAAEFYMKGSVDWIVGADI--FKSNGG IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAAS +R PSK D R+ + YYD VH++SG+ NR Y + G + K IF + Y T + F ++ AA Q ++ LRYFDQPSK----------DGRSIDHASQYYDGLNVHHSSGVYNRAFYLLANKTGWNVRKGFEIFTLANQLYWTANSTFDAGACGVVKAA--QDMGYNSN VVSAAFNSAGIGAKEDIQVNQPSESVLVN V+ AFN G+ A + V PS +VL N DVAEAFNQVGVNA--NCGVTPPSGNVLKN
Show aligned area	163841895	Renibacterium salmoninarum ATCC 33209	haemolysin	548	1e-16	0.31	0.48
RGMPILSVVDEQHPDA--YDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYII--SGASNPEIGADTQ R + + V D Q+ + + NAFW M YG+ T D+ GHE+THGVTE T GL Y +SGA+NES SD+ G I S S+ + A+ RAVVRICVTDSQNGEQCPFANAFWYNGQMTYGQGVTTD--------DITGHELTHGVTEKTNGLVYANESGAINESMSDVFGEFIDLSNGSSDDTAANRW SVDRKTG---IRNLQTPSKHGQPETMAQYDDRARYKGTPYY----------DQGGVHYNSGIINRIGYTI----------IQNLGIEKAQTIFYSSLVNY ++ + IR+++ P K+G+P A YKG+ + DQGGVH NSG+ N++ + I + +GI KA +++++ AIGEGSSLGVIRSMKDPGKYGEP---------AIYKGSNWKPTATNPNDNNDQGGVHSNSGVGNKLAFLITDGQTFNGQTVTGIGIAKAAQLYWAAQ-RQ LTPKAQFSDARDAMLAAAKVQYGDEAASVVSA LT A +S A+ +A + A +A LTANATYSSLGKALNSACSANVSNNVAGTTAA
Show aligned area	119773568	Shewanella amazonensis SB2B	peptidase M4, thermolysin	775	1e-16	0.35	0.54
QHPDAYDNAFWDGKAMRYGETSTPTGKTY---ASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTGI + + Y+NAFWDG AM +G+ G++Y SLDV HE++HG TE +GL Y QSG +NE++SD+ G + + G+++ +GAD D + HYSNNYENAFWDGSAMTFGD-----GQSYFYPLVSLDVSAHEVSHGFTEQNSGLVYANQSGGMNEAFSDMAGEAAEFFMKGSNDWLVGADIFKGD--GAL RNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKA R + P++ G+ ++ DD YYD VHY+SG+ N+ YT+ G KA +F + Y TP + RYMADPTQDGK--SIGHIDD--------YYDGLDVHYSSGVFNKAFYTLATTEGWDTRKAFEVFVIANQLYWTPNS
Show aligned area	113970850	Shewanella sp. MR-4	vibriolysin	500	1e-16	0.35	0.52
YDNAFWDGKAMRYGETSTPTGKTY---ASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTGIRNLQT Y+NAFWDG AM +G+ G +Y SLDV HE++HG TE +GL Y GQSG +NE++SD+ G + + G+++ ++G D V +R + YENAFWDGSAMSFGD-----GASYFYPLVSLDVSAHEVSHGFTEQNSGLNYSGQSGGINEAFSDIAGEAAEFYMRGSNDWKVGYDI--VKGSGALRYMDN PSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAA P K G+ D+ A Y + VHY+SG+ N+ YT+ G KA +F + Y TP + F+ A + AA PPKDGR-----SIDNAANYTSSM-----DVHYSSGVFNKAFYTLATKNGWNTRKAFDVFVLANQLYWTPTSTFNQAACGVQQAA
Show aligned area	27367369	Vibrio vulnificus CMCP6	Zinc metalloprotease	609	2e-16	0.28	0.45
LTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVV + + VG+ T++NS V V ++ +G + Y G +NY+ +A + N DA+ GK V Y+D ++ + + VIDKVGTTCTMENS--VVKTVDLQNRTSG--------STAYSYSCPGASNYNDHKAVNGAYSPLN--DAHYFGKVVYDMYKDW-----MNTAPLTFKLTM DEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLD--VVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTG + Y+NAFWDG AM +G+ ++ T+ +D V HE++HG TE +GL Y SG +NE++SD+ G + + G+ + +GAD G RVHYSSNYENAFWDGSAMTFGDGAS----TFYPLVDINVSAHEVSHGFTEQNSGLIYSNMSGGMNEAFSDIAGEAAEFYMKGSVDWIVGADI--FKSNGG IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAAS +R PSK D R+ + YYD VH++SG+ NR Y + G + K IF + Y T + F ++ AA Q ++ LRYFDQPSK----------DGRSIDHASQYYDGLNVHHSSGVYNRAFYLLANKTGWNVRKGFEIFTLANQLYWTANSTFDAGACGVVKAA--QDMGYNSN VVSAAFNSAGIGAKEDIQVNQPSESVLVN V+ AFN G+ A V PS +VL N DVAEAFNQVGVNAS--CGVTPPSGNVLKN
Show aligned area	169628937	Mycobacterium abscessus	putative metalloprotease	347	2e-16	0.32	0.48
NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGAL + A A+ V +Y + F R+S+D+ GM ++S + + Y NAFW+G M YG+ + S DV+GHE+THGVT+ TAGL+Y ++GAL DATAQRAFDETVAVAEFYRNCFGRNSVDNAGMTLVSSI--HYGVKYSNAFWNGSQMAYGDGDGQIFLDFTKSNDVIGHELTHGVTQFTAGLDYENEAGAL NESYSDLMGYII---SGASNPE-----IGADT---QSVDRK-TGIRNLQTP-SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG NES SD+ G + G + + IG D +++D+ T +R++ P + H + Y D Y H SGI N Y G NESVSDVFGSMFRQWQGQQSADKADWLIGKDILGPRALDKGYTCLRDMADPAAAHCLSPQPSHYRD--------YVPGSDPHEGSGIPNHAFYLAATKYG I---EKAQTIFYSSLVNYLTPKA E T++Y +L +PKA SHSWEAVGTVWYQALT---SPKA
Show aligned area	147671703	Vibrio cholerae O395	hemagglutinin/protease	609	3e-16	0.27	0.44
EHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDE + G+ T+ NS N+ S + + +N+ Y++V YS + DA+ GK V Y+ ++ + + DKTGTTCTMNNSAVKTVNLNGGTSGSTAFSYACNNSTNYNSVKTVNGAYSPLN------------DAHFFGKVVFDMYQ-----QWLNTSPLTFQLTMRV QHPDAYDNAFWDGKAMRYGETSTPTGKTYA-SSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTGIRN + + Y+NAFWDG+AM +G+ T + Y ++V HE++HG TE +GL Y SG +NE++SD+ G Y + G + +GAD G+R HYGNNYENAFWDGRAMTFGDGYT---RFYPLVDINVSAHEVSHGFTEQNSGLVYRDMSGGINEAFSDIAGEAAEYFMRGNVDWIVGADI--FKSSGGLRY LQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVS PS+ D R+ + YY VH++SG+ NR Y + G + K +F + Y TP + F ++ AA+ A VV FDQPSR----------DGRSIDHASQYYSGIDVHHSSGVFNRAFYLLANKSGWNVRKGFEVFAVANQLYWTPNSTFDQGGCGVVKAAQ-DLNYNTADVV- AAFNSAGIGA AAFN+ G+ A AAFNTVGVNA
Show aligned area	15601620	Vibrio cholerae O1 biovar eltor str. N16961	hemagglutinin/protease	609	3e-16	0.27	0.44
EHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDE + G+ T+ NS N+ S + + +N+ Y++V YS + DA+ GK V Y+ ++ + + DKTGTTCTMNNSAVKTVNLNGGTSGSTAFSYACNNSTNYNSVKTVNGAYSPLN------------DAHFFGKVVFDMYQ-----QWLNTSPLTFQLTMRV QHPDAYDNAFWDGKAMRYGETSTPTGKTYA-SSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTGIRN + + Y+NAFWDG+AM +G+ T + Y ++V HE++HG TE +GL Y SG +NE++SD+ G Y + G + +GAD G+R HYGNNYENAFWDGRAMTFGDGYT---RFYPLVDINVSAHEVSHGFTEQNSGLVYRDMSGGINEAFSDIAGEAAEYFMRGNVDWIVGADI--FKSSGGLRY LQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVS PS+ D R+ + YY VH++SG+ NR Y + G + K +F + Y TP + F ++ AA+ A VV FDQPSR----------DGRSIDHASQYYSGIDVHHSSGVFNRAFYLLANKSGWNVRKGFEVFAVANQLYWTPNSTFDQGGCGVVKAAQ-DLNYNTADVV- AAFNSAGIGA AAFN+ G+ A AAFNTVGVNA
Show aligned area	27376145	Bradyrhizobium japonicum USDA 110	extracellular metalloprotease precursor	343	5e-16	0.33	0.46
VKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS V +Y+ F R+SIDD GM ++S V + Y+NA W+G M YG+ + DV+GHE+THGVT+H+ L Y G +G LNES SD G + VARFYQQVFNRNSIDDHGMTMMSSV--HFGEKYNNAMWNGSQMVYGDGDGSIFVDFTRGNDVIGHELTHGVTQHSLQLAYSGDAGGLNESISDCFGSMFR GASNPE--------IGADTQS-VDRKTG---IRNLQTP-SKH---GQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG---IEKAQTI + IG D +K G +R++ P +KH QP +Q TP D HY SG N YT LG + + QWEAKQDVKKADWLIGRDIMGPAAKKKGFACLRDMADPAAKHCLAPQPTKYSQV--------TPGMDP---HYASGPPNLAFYTACTTLGGYSWARIGQV FYSSLVNY +Y SL + WYHSLTGF
Show aligned area	83645274	Hahella chejuensis KCTC 2396	Zinc metalloprotease (elastase)	738	6e-16	0.31	0.50
QHPDAYDNAFWDGKAMRYGETSTPTGKTYASSL---DVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTGI + + Y+NAFWDG M +G+ G +Y L +VV HE++HG TE +GL Y Q G +NE++SD+ G + + G ++ +GA + G+ HYSNGYENAFWDGSQMTFGD-----GASYFYPLVDINVVAHEVSHGFTEFNSGLVYERQPGGMNEAFSDMAGEAAEFFMHGENDFYVGAAI--MKNGDGL RNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV R + P + G A + YYD VHY+SG+ N+ Y + G +KA +F + Y TP + F+D + +AA+ + +A RYMDNPPRDGSSIGHA----------SDYYDGLDVHYSSGVYNKAFYLLATTSGWDTKKAFEVFVRANQTYWTPNSNFNDGACGVESAAEDKGYSKAD-- VSAAFNSAGI V+AAF+ G+ VTAAFDQVGV
Show aligned area	116051721	Pseudomonas aeruginosa UCBPP-PA14	elastase LasB	498	7e-16	0.29	0.50
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYS DA+ G V Y D F + + + + + +NA+WDG AM +G+ +T SLDV HE++HG TE +GL Y GQSG +NE++S DAHFFGGVVFNLYRDWFGTSPLTHK-----LYMKVHYGRSVENAYWDGTAMLFGDGATMFYPLV--SLDVAAHEVSHGFTEQNSGLIYRGQSGGMNEAFS DLMG----YIISGASNPEIGADTQSVDRKTG-IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSS D+ G + + G ++ IG D + + +G +R + PS+ D R+ + YY+ VH++SG+ NR Y + + G KA +F + DMAGEAAEFYMRGKNDFLIGYD---IKKGSGALRYMDQPSR----------DGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEVFVDA LVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI Y T + ++ ++++A Q + +A+ V+ AF++ G+ NRYYWTATSNYNSGACGVISSA--QNRNYSAADVTRAFSTVGV
Show aligned area	115358586	Burkholderia ambifaria AMMD	propeptide, peptidase M4 and M36	565	7e-16	0.24	0.41
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKIIAS----------------- +A + +Q+ V D D G +H++ ++ G+ V +V++H +R G + + Q+ I IG+ G + ++ + QASAPTDGDQFQVRDVIVDPDGTEHVRFDRFHAGLPVIGGDVVVHSNR-GQLKQASQT---QLAPINLAGTIGKVGNRSVVRNAPDIGAARAKHIAAARF -DNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPT---GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGV N D L + R + L Y VRV T GD +++Y ++A GT+++ QDL + + T ++ + ++ +++ T A D + DSNVRRVDDAELVVFAR-DVAPTLAYAVRVYGKATDAHGD--AMLYYIDARTGTVLDAQDLIKTAAATGTGRSLYYGNLSLTTDQTGTN-AYRMLDPSRG YHAVVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAM +V DG+ + I + + V N D T + YY R+ I + G + S V + NA W + M GGSVYDGRGLSSDDVEQATDLPIFTSSTNVWGNNTTTDRQTVAADIDYGLALTWDYYRTTHNRNGIFNDGRGVRSYAHVVFNTGSGTTGANAAWLSSRVM RYGETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETM YG+ T S+DV GHEM+HGVTE TA L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + VYGDGDPGTRLPKPVVSVDVAGHEMSHGVTEATANLNYSGDAGGLNESTSDIFGTLVKFYANNPNDPGNYVIGARVTS----GGLRKMYKQDLDGR--SF AQYDDRARYKGTPYYDQGGVHYNSGIINRIGY-------------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQ + Y P +D H+ SG+ NR Y T LG EKA I+Y +L YL + + +AR A + A SCYPTGGFSWSNPRHDP---HFTSGVGNRFFYLLSEGPVVPSTDTGLSRTQLVCNGDTTFSGLGREKAGKIWYRTLTVYLNANSSYPNARRASIQATNDL YGDEA--ASVVSAAFNSAGI YG + ++ V+ A+++ G+ YGANSVESATVARAWSAVGV
Show aligned area	134101542	Saccharopolyspora erythraea NRRL 2338	extracellular metalloprotease	355	9e-16	0.33	0.47
AVD-AYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNE AVD A+ H ++ + R+SID+ GM + VV DNAFWDG M +G+ S SL V HE+ HGV + L Y GQSGALNE AVDEAFDHFGMTWKFFFEVLARNSIDNAGMTLDGVV--HFGRKVDNAFWDGDQMLFGDGSERLFTRLTKSLSVAAHELGHGVIQFDGPLVYQGQSGALNE SYSDLMGYIISGASNPE--------IGADTQSVDRK-TGIRNLQTPS------KHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG +D G ++ + E +GA+ + K +R+++ P + G+ + A D G D GGVH NSGI N+ + I LG HIADAFGVMVHQWVHHETVEEADWLLGAEILAEGVKGKALRSMKEPGTAFDDPRFGKDKQPAHMKDFVVTAG----DNGGVHINSGIPNKAFFEIASALG ---IEKAQTIFYSSL E+A I Y++L GRSWERAGRILYATL
Show aligned area	119718275	Nocardioides sp. JS614	peptidase M4, thermolysin	430	1e-15	0.34	0.46
YEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIISGASN + + + R S D G P+ V + YDNAFWDG + +G+ + + +DV+GHE+TH VTEHTAGL Y Q GALNES SD+ + FAEVYGRSSYDGAGAPVSLTV--HYGRDYDNAFWDGTQLVFGDGDGRVFGRFTAPVDVLGHELTHAVTEHTAGLRYRDQPGALNESVSDVFAACL---KQ PEIGADTQSVDRKTGIRNLQTPSKHGQP-ETMA----QYDDRA----------RYKGTPYYDQGGVHYNSGIINR---IGYTIIQNLGIEKAQTIFYSSL +G D G + P H + MA YDD A R D GGVH NSGI NR + T I + A ++Y +L RLLGQTAAEADWLIGA-GIFLPGIHARALRDMAAPGTAYDDPALGRDPQVGHLRDYVDTADDNGGVHLNSGIPNRAFQLAATAIGGSTWDGAGRVWYDAL V V V
Show aligned area	218890000	Pseudomonas aeruginosa LESB58	elastase LasB	498	1e-15	0.31	0.53
DNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTG-IRNLQTPSK +NA+WDG AM +G+ +T SLDV HE++HG TE +GL Y GQSG +NE++SD+ G + + G ++ IG D + + +G +R + PS+ ENAYWDGTAMLFGDGATMFYPLV--SLDVAAHEVSHGFTEQNSGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYD---IKKGSGALRYMDQPSR HGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSA D R+ + YY+ VH++SG+ NR Y + + G KA +F + Y T + ++ ++ +A Q + +A+ V+ AF++ ----------DGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSA--QNRNYSAADVTRAFSTV GI G+ GV
Show aligned area	15598919	Pseudomonas aeruginosa PAO1	elastase LasB	498	1e-15	0.31	0.53
DNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTG-IRNLQTPSK +NA+WDG AM +G+ +T SLDV HE++HG TE +GL Y GQSG +NE++SD+ G + + G ++ IG D + + +G +R + PS+ ENAYWDGTAMLFGDGATMFYPLV--SLDVAAHEVSHGFTEQNSGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYD---IKKGSGALRYMDQPSR HGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSA D R+ + YY+ VH++SG+ NR Y + + G KA +F + Y T + ++ ++ +A Q + +A+ V+ AF++ ----------DGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSA--QNRNYSAADVTRAFSTV GI G+ GV
Show aligned area	152985549	Pseudomonas aeruginosa PA7	elastase LasB	498	1e-15	0.29	0.49
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYS DA+ G V Y+D F + + + + + +NA+WDG AM +G+ +T SLDV HE++HG TE +GL Y GQSG +NE++S DAHFFGGVVFKLYKDWFGASPLTHK-----LYMKVHYGRSVENAYWDGTAMLFGDGATMFYPLV--SLDVAAHEVSHGFTEQNSGLVYRGQSGGMNEAFS DLMG----YIISGASNPEIGADTQSVDRKTG-IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSS D+ G + + G ++ IG D + + +G +R + PS+ D R+ YY+ VH++SG+ NR Y + + G KA +F + DMAGEAAEFYMRGKNDFLIGYD---IKKGSGALRYMDQPSR----------DGRSIDNAGQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEVFVDA LVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGI Y T + F+ ++ +A Q + A+ V+ AF++ G+ NRYYWTATSTFNSGACGVIRSA--QNRNYPAADVTRAFSTVGV
Show aligned area	170724922	Shewanella woodyi ATCC 51908	peptidase M4 thermolysin	774	2e-15	0.30	0.47
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYS DA+ G + Y D + D + + + + Y+NAFWDG AM +G+ +T SLDV HE++HG TE + L Y +SG +NE++S DAHFFGNVIYNMYSDWY-----DTAPLTFKLTMRVHYGNNYENAFWDGSAMTFGDGATTFHPLV--SLDVSAHEVSHGFTEQNSNLVYANRSGGMNEAFS DLMG----YIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVN D+ G + + G ++ +GAD D +R ++ P+ D R+ YYD VH++SG+ N+ YT+ G +T F +V DMAGEAAEFFMHGTNDWLVGADIFKAD--GALRYMEDPT----------LDGRSIGDAADYYDGMDVHFSSGVFNKAFYTLANTDGW-NTRTAFQVMVVA ---YLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGA Y T + F D + +AA+ G A V AAF + G+ A NQVYWTANSHFWDGACGVKSAAE-DLGYSTAD-VEAAFMAVGVEA
Show aligned area	21220937	Streptomyces coelicolor A3(2)	metalloproteinase (secreted protein)	547	2e-15	0.30	0.43
AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKA--MRYGETSTPTGKTYAS--SLDVVGHEMTHGVTEHTAGLEYLGQSGA AVDA YYED R I G + V + Y+NAFWD M YG+ G + SLDV GHEM+HGVT TA L Y G+ G AVDAQYGTDATWDYYEDVHGRRGIAGDGKGSYNRV--HYGTRYNNAFWDDGCFCMTYGDGD---GTAFGPLVSLDVAGHEMSHGVTSKTAALTYSGEPGG LNESYSDLMGYIIS----GASNPEIGADTQSVDR----KTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGY----------- LNE+ SD+ G ++ +++P + V R + +R L PS+ G A T D VHY+SG+ N Y LNEATSDIFGALVEWHADNSADPGDYLIGEKVVRDGFGRNALRYLDRPSRDGS---------SADCWSTSLGDL-DVHYSSGVANHFAYLLAEGSGARTV ------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAA--SVVSAAFNSAGIG + + +G +K I+Y +L Y+T ++ AR A L+AA YG + + V AA+++ +G GGVAYDSPTCDGSTVSGIGRDKLGDIWYRALTVYMTSSTDYAGARAATLSAAGDLYGTRSTEYAAVGAAWSAVSVG
Show aligned area	78046051	Xanthomonas campestris pv. vesicatoria str. 85-10	Zinc metalloprotease precursor	532	2e-15	0.26	0.40
SEVSTVLSKLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKIIASDNPET S ++L + A A+ + D DA G +H++ ++ +G+ V +V++H R G + ++ +D V+ V I ++ S SRAQSLLGNNASALANRAPADAFIARDSIVDADGTEHVRFDRTYQGLPVIGGDVVVH-SRRGVMRELS-QTMDTTVRPSLVPGIDAATALRVAGSHFDVA KDLVFLAIDKRVNNEG--QLFYKVRVTS-SPTGDPVSLVYKVNATDGTIMEKQDLTEHV----GSEVTLKNSFQVAFNVPVEKSN-TGIALHGTDNTGVY +D A +G +L Y+V + P P + Y V+A + I+E D T H G+ A +V V + + + TD + QDAAPRASLALYARQGAPRLVYEVIYSGVKPDQTPTEMHYIVDAVNQRILESWD-TVHTACSGGTSAAGTGRSLYAGSVTVNTTRCSSTSYEMTDLSRGS HAVVDGKNNYSIIQAPSLVALNQN-------------AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGK--AMRYGETSTP A + +N+ S +LV N AVDA+ YY R I + G S V + Y+NAFW M +G+ GATYNMRNSTS--GNGTLVTDADNAWGSGTTGDTVTAAVDAHYGVALTWDYYRTTHSRTGIANDGAGARSRV--HYGSRYNNAFWQDSCFCMTFGDGDGS TGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYII--SGASNPEIG----ADTQSVDRKTG---IRNLQTPSKHGQPETMAQYDDRA T T S+DV GHEMTHGVT TA L Y G+SG LNE+ SD+MG ++ S A++ E G + + TG +R + PS G+ D + T-FTPLVSVDVAGHEMTHGVTSRTAALTYSGESGGLNEATSDIMGTMVEYSAANSAEPGNYLIGEKIIPNNSTGTLALRYMFKPSLDGKSP-----DCYS RYKGTPYYDQGGVHYNSGIINRI------------------------------GYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYG G+ VHY SG+ N G T + +G A I+Y +L Y+T ++ AR A L+AA YG SSLGSL-----NVHYRSGVANHFYYLLAEGAVVPSGFGSGTSYNLTPTSLVCSGSTALTAIGRAAASRIWYRALTVYMTSSTNYAAARRATLSAATDLYG
Show aligned area	29829336	Streptomyces avermitilis MA-4680	neutral zinc metalloprotease	681	2e-15	0.30	0.45
DAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKA--MRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNES DA+ +Y+ F R I + G+ S V + +AY NAFWD M YG+ S +SLDV GHEM+HGVT +TA L Y G+SG LNE+ DAHYGAATTWDFYKTTFGRSGIKNNGVGAYSRV--HYGNAYVNAFWDDSCFCMTYGDGSGNADPL--TSLDVAGHEMSHGVTSNTANLNYSGESGGLNEA YSDLMGYIIS--GASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSG----------------IINRIGYTI--- SD+ G + A++ ++G + K I TP ++ + + Y G D VHY+SG +IN + Y TSDIFGTGVEFFAANSSDVG--DYLIGEKIDINGDGTPLRYQDKPSKDGASKDSWYSGIGSID---VHYSSGPANHFFYLLSEGSGAKVINGVSYNSPTS ----IQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAAS--VVSAAFNSAGIGAK + +G +KA I+Y +L T ++ AR LAAA YG + V A+ + +GA+ DGLPVTGIGRDKALQIWYRALTTKFTSTTNYAAARTGTLAAAGELYGTTSTEYKAVQDAWAAVAVGAR
Show aligned area	172063329	Burkholderia ambifaria MC40-6	peptidase M4 thermolysin	565	2e-15	0.25	0.40
EAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKIIAS----------------- +A + +Q+ V D D G +H++ ++ G+ V +V++H R G + + Q+ I IG+ G + ++ + QASAPTDGDQFQVRDVIVDPDGTEHVRFDRFHAGLPVIGGDVVVHSHR-GQLKQASQT---QLAPINLAGTIGKVGNRSVVRNAPDVGAARAKLIAAARF -DNPETKDLVFLAIDKRVNNEGQLFYKVRVTSSPT---GDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVAFNVPVEKSNTGIALHGTDNTGV N D L + R + L Y VRV + T GD V +Y ++A GT+++ QDL + + T ++ + + +++ T A D + DSNVRRVDDAELVVFTR-DVAPTLAYAVRVYGNATDAHGDAV--LYYIDARTGTVLDAQDLIKTAAATGTGRSLYYGNLALTTDQTGTN-AYRMLDPSRG YHAVVDGK----------NNYSIIQAPSLVALNQNAVDAYTHGKFVK-------TYYEDHFQRHSIDDRGMPILS----VVDEQHPDAYDNAFW-DGKAM +V DG+ + I + + V N D T + YY R+ I + G + S V + NA W + M GGSVYDGRGLSSDDVEQATDLPIFTSSTNVWGNNTTTDRQTVAADIDYGLALTWDYYRTTHNRNGIFNDGRGVRSYAHVVFNTGSGTTGANAAWLSSRVM RYGETSTPTG-KTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPE------IGADTQSVDRKTGIRNLQTPSKHGQPETM YG+ T S+DV GHEM+HGVTE TA L Y G +G LNES SD+ G ++ A+NP IGA S G+R + G+ + VYGDGDPGTRLPKPVVSVDVAGHEMSHGVTEATANLNYSGDAGGLNESTSDIFGTLVKFYANNPNDPGNYVIGARVTS----GGLRKMYKQDLDGR--SF AQYDDRARYKGTPYYDQGGVHYNSGIINRIGY-------------------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQ + Y P +D H+ SG+ NR Y T LG EKA I+Y +L YL + + +AR A + A SCYPSGGFSWSNPRHDP---HFTSGVGNRFFYLLSEGPVVPSTDTGLSRTQLVCNGDTTFSGLGREKAGKIWYRTLTVYLNANSSYPNARRASIQATNDL YGDEA--ASVVSAAFNSAGI YG + ++ V+ A+++ G+ YGANSVESATVARAWSAVGV
Show aligned area	117618830	Aeromonas hydrophila subsp. hydrophila ATCC 7966	elastase	589	3e-15	0.33	0.47
YDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGY----IISGASNPEIGADTQSVDRKTGIRNLQTPSK Y+NAFWDG M +G+ +T SLDV HE++HG TE +GL Y GQSG +NE++SD+ G + G+++ +GA Q +R + P++ YENAFWDGSQMTFGDGATTFYPLV--SLDVAAHEVSHGFTEQNSGLVYSGQSGGINEAFSDMAGEAAENFMKGSNDWLVGA--QIFKGNGSLRYFEDPTR HGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASV--VSAAFN G A + YYD VH++SG+ NR Y + G KA +F + Y F + AA D SV V+AAF DGSSIGHA----------SDYYDGIDVHHSSGVYNRAFYLLANTSGWNTRKAFEVFVLANRLYWGANTTFDQGACGVTKAAT----DLGYSVTDVAAAFT SAGIGAKEDIQVNQPSESVLVN + G+ A QP SVL N TVGVNASCGGTTPQPG-SVLQN
Show aligned area	29832212	Streptomyces avermitilis MA-4680	neutral zinc metalloprotease	531	6e-15	0.26	0.39
AAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQL AA+ +V D DA G +H++ ++ + V + ++HL NG+ D+ + AI + +++ P+ DL A+ R N G+L AAQGTSVRDVVVDADGGQHVRYDRTYRHLPVLGGDFVVHLAPNGSYRGA-----DRSTR----RAISLADITPALSA--PKAADLATAAL--RAANTGEL FYKVR----------------------VTSSPTGDPVSLVYKVNATDGTIMEKQDLTEH------------VGSEVTLKNSFQVAFNVPVEKSNTGIALH KV V G+PV+ +A G ++ D E V E TL S + + TG A + LKKVTAKPQLVVDALHGAPKLAWRTNVVGQDSLGNPVARTVLTDARSGKQIDAWDSIETATGDGKSLYSGTVALESTLSGSTYQLKDATRGNTYTGDAAN GTD--------NTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKA--MRYGET TD + D N++ A + AVDA YY++ R+ I G + V + Y+NAFWD M YG+ KTDLCILGICFSRAPATLFTDADNHWGTGAASDR---SSAAVDAQYGTNETWDYYKNVHGRNGIAGDGKGSYNRV--HYGSNYNNAFWDDSCFCMTYGDG STPTGKTYAS--SLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYIIS-GASNPEIGAD-------TQSVDRKTGIRNLQTPSKHGQ------- G T+ +LDV GHEM+HGVT TA L Y G+SG LNE+ SD+ G ++ A+N D +S K +R + PSK G D---GTTFGPLVALDVAGHEMSHGVTSKTAALTYSGESGGLNEATSDVFGTLVEFHANNSSDAGDYLIGEKIVRSGFGKAALRFMDKPSKDGNSADCWSS ---------PETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYG +A + +G+ GV YNS N + + +G +K I+Y +L Y+T ++ AR A L+AAK YG SVGNLDVHYSSGVANHFAYLLAEGSGAKTVNGVSYNSPTCNG---STVTGIGRDKLGAIWYRALTVYMTSSTNYAGARTATLSAAKDLYG
Show aligned area	91794365	Shewanella denitrificans OS217	peptidase M4, thermolysin	777	6e-15	0.33	0.49
AYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTGIRNLQTPS Y+NAFWDG AM +G+ +T SLDV HE++HG TE +GL Y QSG +NE++SD+ G + + GA++ +GAD +R + P+ GYENAFWDGSAMTFGDGATRFHPLV--SLDVSAHEVSHGFTEQNSGLIYANQSGGMNEAFSDMAGEAAEFYMRGANDWLVGADI--FKASGALRYMADPT KHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVN--YLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNS G ++ DD YYD VH++SG+ N+ YT+ G + + N Y T + F + +AA G AA VV+ AF LDGN--SIGHIDD--------YYDGMNVHHSSGVFNKAFYTLANMPGWDTRSAFQTFVVANQLYWTANSLFWQGACGVKSAA-TDLGLSAADVVT-AFAV AGI GI VGI
Show aligned area	77748526	Xanthomonas axonopodis pv. citri str. 306	metalloproteinase	504	1e-14	0.25	0.39
AAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSVTGNPVDQVVK------IQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKR A A+ + D DA G +H++ ++ +G+ V +V++H R G + ++ +D V+ I + A+ G +A D L A APADAFIARDSIVDADGTEHVRFDRTYQGLPVIGGDVVVH-SRRGVMRELS-QTMDTTVRPSLLPGIDAATALRVAGSHFDVAQDAAPRASLALYA---- VNNEGQLFYKVRVTS-SPTGDPVSLVYKVNATDGTIMEKQDLTE----------------HVGS-EVTLKNSFQVAFNVPVEKSNTGIALHGTDNT-GVY +L Y+V + P P + Y V+A I+E D + GS V ++ + +G + ++T G RQGAPRLVYEVIYSGVKPDQTPTEMHYIVDAVTQRILESWDTVHTACSGGTSAAGTGRSLYAGSVTVNTTRCSSTSYELTDLSRGSGATYNMRNSTSGNG HAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKA--MRYGETSTPTGKTYASSLDVVG V D N + V AVDA+ YY R I + G S V + Y+NAFW M +G+ T T S+DV G TLVTDADNAWGSGTTGDTVTA---AVDAHYGVALTWDYYRTTHSRTGIANDGAGARSRV--HYGSRYNNAFWQDSCFCMTFGDGDGST-FTPLVSVDVAG HEMTHGVTEHTAGLEYLGQSGALNESYSDLMGYII--SGASNPEIG----ADTQSVDRKTG---IRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGV HEMTHGVT TA L Y G+SG LNE+ SD+MG ++ S A++ E G + + TG +R + PS G+ D + G+ V HEMTHGVTSRTAALTYSGESGGLNEATSDIMGTMVEYSAANSAEPGNYLIGEKIIPNNSTGTLALRYMFKPSLDGKSP-----DCYSSSLGSL-----NV HYNSGIINRI------------------------------GYTIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYG HY+SG+ N G T + +G A I+Y +L Y+T ++ AR A L+AA YG HYSSGVANHFYYLLAEGAVVPSGFGSGTSYNLTATSLVCSGSTALTAIGRVAASRIWYRALTVYMTSSTNYAAARRATLSAATDLYG
Show aligned area	145223335	Mycobacterium gilvum PYR-GCK	Zinc metalloprotease (elastase)-like protein	880	2e-14	0.30	0.46
NQNAVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVD---EQHPDAYDNAFWDG--KAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAG----L ++ AV A+ + Y+ D R S D+ G P++ + + +P Y NA WD + YG+ + ++LD+V HE H V G + DKAAVSAHANHAVAYDYFYDVLGRRSYDNAGAPVIVSIKYRPDSYPLGYANAMWDPTIRQFAYGDKGY-----FQAALDIVAHEYAHAVVTSMVGNGDPV EYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQ-----NL G+SGALNE+Y+D+ G +I G S + + D T IR+L P + + DR + T D GG H NS I + Y ++ ++ WESGESGALNEAYADVFGLLIEGKSGADRWLIAEDSDNGT-IRDLANP--RSITTSYGPHRDRYSTRYTGKGDDGGEHVNSTIFSHAAYLMMTDPATADV GIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQ + +FY SL L A FSD R A+L AA Q SDDTWAKVFYHSL-ERLGATAMFSDGRAALLDAALSQ
Show aligned area	182437841	Streptomyces griseus subsp. griseus NBRC 13350	putative neutral zinc metalloprotease	540	3e-14	0.28	0.42
AVDAYTHGKFVKTYYEDHFQRHSIDDRGMPILSVVDEQHPDAYDNAFWDGKA--MRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAGLEYLGQSGALN AVDA+ +Y+ R I G S V + + Y NAFWD M YG+ K +S+DV HEMTHG+T TA L+Y G+SG LN AVDAHYGAAKTWDFYKSALGRDGIAGDGKAAYSRV--HYGENYVNAFWDDSCFCMTYGDGEG--NKAALTSIDVAAHEMTHGLTSATANLDYAGESGGLN ESYSDLMGYII-------SGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMAQYDDRARYKGTPYYDQG----GVHYNSGIINRIGY---------- E+ SD++G + S A + IG T +R + PSK G ++D+ VHY+SG+ N Y EATSDILGASVEFFADNASDAGDYLIGEKIDINGDGTPLRYMDKPSKDGN--------------SADFWDENLGNLDVHYSSGVANHFFYLLAEGSGKKT -------------TIIQNLGIEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAK + + +G EKA I+Y +L Y+T ++ AR A AA +G ++ + + + G+ K VNGVEYDSATSDGSTLTGIGREKAYQIWYKALSVYMTSTTDYAGARVATEKAATDLFGADSEELKAVSATWTGVNVK
Show aligned area	218709260	Vibrio splendidus LGP32	Extracellular zinc metalloprotease	607	4e-14	0.33	0.48
YDNAFWDGKAMRYGETSTPTGKTYASSLD--VVGHEMTHGVTEHTAGLEYLGQSGALNESYSDLMG----YIISGASNPEIGADTQSVDRKTGIRNLQTP Y+NAFW+G +M +G+ T+ +D V HE++HG TE +GL Y SG +NE++SD+ G Y + G + +G+D + G+R P YENAFWNGTSMTFGDGKN----TFYPLVDINVSAHEVSHGFTEQNSGLVYQNMSGGINEAFSDIAGEAAEYYLRGNVDWVVGSDI--FKSEGGLRYFDQP SKHGQPETMAQYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLG--IEKAQTIFYSSLVNYLTPKAQFSDARDAMLAAAKVQYGDEAASVVSAAFN SK D R+ + YYD VH +SG+ NR Y + G + K IF + Y T + F DA +A A G A V AFN SK----------DGRSIDHASQYYDGLNVHLSSGVYNRAFYLLANKSGWNVRKGFEIFTVANQLYWTANSTF-DAGACGVAKAAADMGYVVAD-VEDAFN SAGIGA + G+ A TVGVNA