LAB-Secretome DB


LAB-Secretome DB A comparative analysis of the predicted secretomes of Lactic Acid Bacteria

Protein with distant homolog in non-LAB species

GI:116333913
NCBI info	116333913	Gene:	-	Synonym:	LVIS_1304
SCL:	@N-terminally anchored (No CS)	Length	321	COG	-
Species:	Lactobacillus_brevis_ATCC_367	Location	1275913..1276878	Strand:	-
Product:	VIP2; A family of actin-ADP-ribosylating toxin
Sequence:	MLRKLGLSLIVIGGVLTIGTKNVNAASFASGDSIVSMTTRNNYIHDSKYRYLVTKKNAIAYKAIGKAPDYTASVSISKNVPLTVRQTVEGGHIVTEPQST DKLFLSNDKQFVYSSDVKSLSKKQIKVLAKDSKKWSSKIGKKSVQAVGYYTGDGYEKINGYLRNGKGQKKVVKKAQLVQKGISKFKLRYNTTVYRGISNK GLKLSLNNRGLSVGSIYQDKAFSSTSLSKQVALGFSSQCLLRINIPAGSHGAYIDPISKNKGEKEYLLKEGQKLIVTKIQNVSYTEATKMYLIKNKGSKV VQHTTNNVKGNYKLITLNLLN

Protein Domain structure of 116333913 (Scale up the web page to see more details)

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Distant Homologs of 116333913 in the non-LAB species

Alignment	GI	Species	Product	Length	Eval	Identities	Positives
Show aligned area	15616093	Bacillus halodurans C-125	hypothetical protein BH3531	490	2e-15	0.32	0.50
LAKDSKKWSSKIGKKSVQAVGYYTGDGYEKINGYLRNGK-GQKKVVKKAQLVQKGISKFKLRYNTTVYRGISNKGLKLSLNNRGLSVGSIYQDKAFSSTS L KD W + +A+ YTG Y KINGYLR + G ++V ++ + + + I KF+L+ VYR + L S G+IY+D + STS LGKDDLNWIKGLSADENEAIREYTGTAYRKINGYLRGKRPGSERVKEQIKHIDEAIRKFELKDGIMVYRNVGRDALPSSSERLKDLEGTIYKDDGYMSTS LSKQVALGFSSQCLLRINIPAGS-HGAYIDPISKNKGEK-EYLLKEGQKLIVTKIQNVSYTEATKMYLIKN + ++ A S + I +P G GAYI+ IS K E+ E+L+K G +T++ +M +I + VLREGAFS-SYDVMFEITVPGGKGRGAYINEISLFKDEEYEFLIKRGASFRITEVVEEGRMTVIRMEMIDD
Show aligned area	29374974	Enterococcus faecalis V583	minor head protein	487	4e-12	0.35	0.51
LAKDSKKWSSKIGKKSVQAVGYYTGDGYEKINGYLRNGKGQKK----VVKKAQLVQKGISKFKLRYNTTVYRGISNKGLKLSLNNRGLSVGSIYQDKAFS L DS KW + + + V A+ YT D + K+N LRN K + +V Q + ISKFKL+++ YRG+S LN G+++ K F LQDDSDKWVAGLKPEQVNAMKDYTSDAFAKMNKILRNEKYNPREKPYLVNIIQNLDDAISKFKLKHDIITYRGVSANEYDAILN------GNVF--KEFK STSLSKQVA---LGFSSQC----LLRINIPAGSHGAYIDPISKNKGEKEYLLKEGQKLIVTKIQNV STS++K+VA L F+S +++ IP G+ GAYI S K E E+LL K V + N+ STSINKKVAEDFLNFTSANKDGRVVKFLIPKGTQGAYIGTNSSMKKESEFLLNRNLKYTVEIVDNI
Show aligned area	16802114	Listeria monocytogenes EGD-e	hypothetical protein lmo0066	604	9e-09	0.31	0.53
WSSKIGKKSVQAVGYYTGD-GYEKINGYLRNGKGQKKVVKKAQLVQK---GISKFKLRYNTTVYRGISNKGLKLSLNNRGLS----VGSIYQDKAF-SST W + + + +QA+ YT Y +NGYLR G +K A+ ++ + K +L N +YRG S++ L L+ + L+ VG ++K F S+T WRNSLSSREIQAIRDYTDIWHYGNMNGYLR-GSVEKLAPDNAERIKNLSSALEKAELPDNIILYRGTSSEILDNFLDLKNLNYQNLVGKTIEEKGFMSTT SLSKQVALGFSSQCLLRINIPAGSHGAYIDPISKNKGEKEYLLKEGQKLIVTKIQNVS ++S Q FS ++IN P GS GAY+ S+ E E L GQK+++ ++ ++ TISNQT---FSGNVTMKINAPKGSKGAYLAHFSETPEEAEVLFNIGQKMLIKEVTELN
Show aligned area	15893630	Clostridium acetobutylicum ATCC 824	Mono-ADP-ribosyltransferase C3	388	1e-07	0.30	0.49
WSSKIGKKSVQAVGYYTGDGYEKINGYLRNGKGQKKVV--KKAQLVQKGISKFKLRYNTTVYRG--------ISNKGLKLSLNNRGLSVGSIYQDKAFSS W + A+ YTG+ Y+KIN YLR + K + ++ G+ K + ++ VYRG + + G SL+ L VG ++D F S WLKSLNDSERNAIRQYTGNDYKKINNYLRGVNDSLDGIDPKIIEDIKSGLKKASVPHDMKVYRGTDLNPLRNLIDVGKDGSLDFSSL-VGKTFKDDGFMS TSLSKQVALGFSSQCLLRINIPAGSHGAYIDPISKNKGEKEYLLKEGQKLIVTK T+L K+ + + + IN+P G+ AY+ IS E E LL GQ++I+ + TALVKESSFDYMNVSW-EINVPKGTEAAYVSKISYFPDEAELLLNHGQEMIIKE
Show aligned area	17233491	Salmonella typhimurium LT2	hydrophilic protein	591	4e-06	0.26	0.40
AKDSKKWSSKIGKKSVQAVGYYTGDGYEKINGYLRNGKGQKKVVKKAQL-------------------------VQKGISKFKLRYNTTVYRGISNKGLK ++ KW+ K +QA+ YY+ GY IN YLR + K+ L + +G+S + VYRG+ SRPKSKWAIVEESKQIQALRYYSAQGYSVINKYLRGDDYPETQAKETLLSRDYLSTNEPSDEEFKNAMSVYINDIAEGLSSLPETDHRVVYRGLKLDKPA LS-LNNRGLSVGSIYQDKAFSSTSLSKQVALGFSSQCLLRINIPAGSHGAYIDPISKNKGEKEYLLKEGQKLIVTKIQNVSYTEATKMYLIKNKGSKVVQ LS + ++G+I DKAF STS K + + +L I + G G + ++ KGE E L KL + I N + L K + S LSDVLKEYTTIGNIIIDKAFMSTSPDK----AWINDTILNIYLEKGHKGRILGDVAHFKGEAEMLFPPNTKLKIESIVNCGSQDFASQ-LSKLRLSDDAT HTTNNVKGNYKLITLNLLN TN +K ++I + +LN ADTNRIK---RIINMRVLN
Show aligned area	60115466	Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67	65 kDa virulence protein	591	5e-06	0.26	0.40
AKDSKKWSSKIGKKSVQAVGYYTGDGYEKINGYLRNGKGQKKVVKKAQL-------------------------VQKGISKFKLRYNTTVYRGISNKGLK ++ KW+ K +QA+ YY+ GY IN YLR + K+ L + +G+S + VYRG+ SRPKSKWAIVEESKQIQALRYYSAQGYSVINKYLRGDDYPETQAKETLLSRDYLSTNEPSDEEFKNAMSVYINDIAEGLSSLPETDHRVVYRGLKLDKPA LS-LNNRGLSVGSIYQDKAFSSTSLSKQVALGFSSQCLLRINIPAGSHGAYIDPISKNKGEKEYLLKEGQKLIVTKIQNVSYTEATKMYLIKNKGSKVVQ LS + ++G+I DKAF STS K + + +L I + G G + ++ KGE E L KL + I N + L K + S LSDVLKEYTTIGNIIIDKAFMSTSPDK----AWINDTILNIYLEKGHKGRILGDVAHFKGEAEMLFPPNTKLKIESIVNCGSQDFASQ-LSKLRLSDDAT HTTNNVKGNYKLITLNLLN TN +K ++I + +LN ADTNRIK---RIINMRVLN
Show aligned area	161503407	Salmonella enterica subsp. arizonae serovar 62:z4,z23:--	hypothetical protein SARI_01481	595	6e-06	0.26	0.40
AKDSKKWSSKIGKKSVQAVGYYTGDGYEKINGYLRNGKGQKKVVKKAQLVQK--------------------------GISKFKLRYNTTVYRGISNKGL ++ KW+ K +QA+ YY+ GY IN YLR G ++ K L+ + G+S + VYRG+ SRPKSKWAIVEESKQIQALRYYSAQGYSVINKYLR-GDDYPEIQAKETLLSRDYLSTNEPSDEEFKNAMSVYINDIVEGLSSLPETDHRVVYRGLKLDKP KLS-LNNRGLSVGSIYQDKAFSSTSLSKQVALGFSSQCLLRINIPAGSHGAYIDPISKNKGEKEYLLKEGQKLIVTKIQNVSYTEATKMYLIKNKGSKVV LS + +VG+I DKAF STS K + + +L I + G G + ++ KGE E L KL + I N + L K + S ALSDVLKEYTTVGNIIIDKAFMSTSPDK----AWINDTILNIYLEKGHKGRILGDVAHFKGEAEMLFPPNTKLKIESIVNCGSQDFASQ-LSKLRLSDDA QHTTNNVKGNYKLITLNLLN TN +K ++I + +LN TADTNRIK---RIINMRVLN
Show aligned area	29831978	Streptomyces avermitilis MA-4680	hypothetical protein SAV_5435	824	1e-05	0.28	0.51
QAVGYYTGDGYEKINGYLR--NGKGQKKVVKKAQLVQKGISKFKLRYNTTVYRGISNKGLKLSLNNRGLSVGSIYQDKAFSSTSLSKQVALGFSSQ-CLL +A+ YTG Y +IN +LR N + + + + + + + + RG + LKL L G+ Y D A++S++L + V F+ + ++ EALRTYTGHDYTEINSHLRGENPDVYPETLHTIDEMDRVMGTRPVPEDIMIVRGTGIEHLKLRSPLDML--GNTYGDGAYTSSALGRTVPPAFAWKPVVM RINIPAGSHGAYIDPISKNKGEKEYLLKEGQKLIVTKI +P G+ ++D ISK+ GE+E LL G + VT++ HWRVPKGTPALWLDKISKHPGERELLLARGTQYKVTRV
Show aligned area	154247631	Xanthobacter autotrophicus Py2	hypothetical protein Xaut_3706	623	2e-04	0.26	0.43
KKQIKVLAKDSKKWSSKIGKKSVQAVGYYTGDGYEKINGYLRNGKGQ--------------KKVVKKAQ-LVQKGISKFKLRYNTTVYRGISNKGLKLSL +K+I+ + K + ++ + +YTG GY ++N LR G G V +KA LV +G++ + T+ Y RKEIETILKSAPAPYKRLSIGQAGLINWYTGSGYRRLNKDLREGTGNWLTPMISDALNGALDAVTRKATGLVTRGLNVYSDAEITSTY------------ NNRGLSVGSIYQDKAFSSTSLSKQVALGFSSQCLLRINIPAGSHGAYIDPISKNKGEKEYLLKEGQKLIVT +VG+ + AF+ST GFS +R+ I GS G + P+S+ + E E L K G + IVT -----AVGAAVEFPAFTST------GRGFSFGGNVRM-IIDGSSGVDVKPLSRFRNENEVLFKAGTRFIVT
Show aligned area	156974352	Vibrio harveyi ATCC BAA-1116	hypothetical protein VIBHAR_02067	249	5e-04	0.31	0.47
QIKVLAKDSKKWSSK-IGKKSVQAVGYYTGDGYEKINGYLRN---------GKGQKKVVKKAQLVQKGISKFKLRYNTTVYRGISNKG--LKLSLNNRGL Q AK S W + + +K ++A+ ++ GY+ N YLR GK KK +K+ ++ +SK Y+GI+ +G +K SL N+ L QFSDWAKASSGWRFRFMTEKDLEALEDFSVSGYQSANDYLRATDTSTWGQYGKTTKKFIKQ---IRGAMSKLP------EYKGITYRGAWVKESLLNK-L SVGSIYQDKAFSSTSLSKQVALGF------SSQCLLRI--NIPAGSHGAYIDPISKNKGEKEYLLKEGQKLIVTKIQ VG + + AF+S+S +VA F S Q L R I S+G + +S+ GE E LL VTKI+ QVGDVVVEPAFTSSSAIPEVAKRFAITRPNSPQPLQRALYEIQIKSNGRALGGLSEFGGEAEVLLPPNTYYKVTKIE